A report on asthma genetics studies in Pakistani population
Pakistan is globally sixth most populous, economically developing south Asian country with tremendously increasing trend of urbanization. This increase in urbanization along with consanguineous marriages trend in Pakistani nationals might contribute as most important factors of increasing asthma pre...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Running Line
2017-02-01
|
| Series: | Advancements in Life Sciences |
| Subjects: | |
| Online Access: | http://www.als-journal.com/422-17/ |
| _version_ | 1797760805463130112 |
|---|---|
| author | Muhammad Usman Ghani Muhammad Farooq Sabar Mariam Shahid Farheena Iqbal Awan Muhammad Akram |
| author_facet | Muhammad Usman Ghani Muhammad Farooq Sabar Mariam Shahid Farheena Iqbal Awan Muhammad Akram |
| author_sort | Muhammad Usman Ghani |
| collection | DOAJ |
| description | Pakistan is globally sixth most populous, economically developing south Asian country with tremendously increasing trend of urbanization. This increase in urbanization along with consanguineous marriages trend in Pakistani nationals might contribute as most important factors of increasing asthma prevalence.
Up-till now, a few studies related to asthma genetics have been conducted in Pakistan. These studies suggest that the SNP variants like (rs2569190, rs2569191), (rs2243250, rs2227284), (rs1800896), (rs1881457, rs20541, rs1800925), (rs2280091, rs2787094, rs528557), (rs1131882) in CD14, IL-4, IL10, IL-13, ADAM33 and TBXA2R genes respectively and the SNPs (rs3816470, rs6503525, rs3859192, rs12603332) on chromosomal region 17q21 are significantly associated in Pakistani population whereas the haplotype “CCTCAG" of SNPs (rs12936231, rs7216389, rs7216558, rs9894164, rs1007654 and rs7212938) in 17q21 and ‘AAGTCG’ of SNPs (rs2280089, rs2280090, rs2280091, rs44707, rs528557, and rs612709) in ADAM-33 region are protective factor against asthma susceptibility.
These studies will definitely contribute in understanding genetic basis of asthmatic complications in Pakistan and large population cohort size and sub-ethnic studies in future will give more meaningful conclusions to predict possible asthma susceptible genomic variants in sub-ethnic and general population of Pakistan. |
| first_indexed | 2024-03-12T19:03:50Z |
| format | Article |
| id | doaj.art-ff314ff96a894151b91320d47a787a60 |
| institution | Directory Open Access Journal |
| issn | 2310-5380 2310-5380 |
| language | English |
| last_indexed | 2024-03-12T19:03:50Z |
| publishDate | 2017-02-01 |
| publisher | The Running Line |
| record_format | Article |
| series | Advancements in Life Sciences |
| spelling | doaj.art-ff314ff96a894151b91320d47a787a602023-08-02T06:28:31ZengThe Running LineAdvancements in Life Sciences2310-53802310-53802017-02-01423338A report on asthma genetics studies in Pakistani populationMuhammad Usman Ghani0Muhammad Farooq Sabar1Mariam Shahid2Farheena Iqbal Awan3Muhammad Akram4CAMB, University of the Punjab, Lahore – PakistanCAMB, University of the Punjab, Lahore – PakistanCAMB, University of the Punjab, Lahore – PakistanCAMB, University of the Punjab, Lahore – PakistanCAMB, University of the Punjab, Lahore – PakistanPakistan is globally sixth most populous, economically developing south Asian country with tremendously increasing trend of urbanization. This increase in urbanization along with consanguineous marriages trend in Pakistani nationals might contribute as most important factors of increasing asthma prevalence. Up-till now, a few studies related to asthma genetics have been conducted in Pakistan. These studies suggest that the SNP variants like (rs2569190, rs2569191), (rs2243250, rs2227284), (rs1800896), (rs1881457, rs20541, rs1800925), (rs2280091, rs2787094, rs528557), (rs1131882) in CD14, IL-4, IL10, IL-13, ADAM33 and TBXA2R genes respectively and the SNPs (rs3816470, rs6503525, rs3859192, rs12603332) on chromosomal region 17q21 are significantly associated in Pakistani population whereas the haplotype “CCTCAG" of SNPs (rs12936231, rs7216389, rs7216558, rs9894164, rs1007654 and rs7212938) in 17q21 and ‘AAGTCG’ of SNPs (rs2280089, rs2280090, rs2280091, rs44707, rs528557, and rs612709) in ADAM-33 region are protective factor against asthma susceptibility. These studies will definitely contribute in understanding genetic basis of asthmatic complications in Pakistan and large population cohort size and sub-ethnic studies in future will give more meaningful conclusions to predict possible asthma susceptible genomic variants in sub-ethnic and general population of Pakistan.http://www.als-journal.com/422-17/AsthmaGeneticsSNPPakistanReview |
| spellingShingle | Muhammad Usman Ghani Muhammad Farooq Sabar Mariam Shahid Farheena Iqbal Awan Muhammad Akram A report on asthma genetics studies in Pakistani population Advancements in Life Sciences Asthma Genetics SNP Pakistan Review |
| title | A report on asthma genetics studies in Pakistani population |
| title_full | A report on asthma genetics studies in Pakistani population |
| title_fullStr | A report on asthma genetics studies in Pakistani population |
| title_full_unstemmed | A report on asthma genetics studies in Pakistani population |
| title_short | A report on asthma genetics studies in Pakistani population |
| title_sort | report on asthma genetics studies in pakistani population |
| topic | Asthma Genetics SNP Pakistan Review |
| url | http://www.als-journal.com/422-17/ |
| work_keys_str_mv | AT muhammadusmanghani areportonasthmageneticsstudiesinpakistanipopulation AT muhammadfarooqsabar areportonasthmageneticsstudiesinpakistanipopulation AT mariamshahid areportonasthmageneticsstudiesinpakistanipopulation AT farheenaiqbalawan areportonasthmageneticsstudiesinpakistanipopulation AT muhammadakram areportonasthmageneticsstudiesinpakistanipopulation AT muhammadusmanghani reportonasthmageneticsstudiesinpakistanipopulation AT muhammadfarooqsabar reportonasthmageneticsstudiesinpakistanipopulation AT mariamshahid reportonasthmageneticsstudiesinpakistanipopulation AT farheenaiqbalawan reportonasthmageneticsstudiesinpakistanipopulation AT muhammadakram reportonasthmageneticsstudiesinpakistanipopulation |