Effect of Focal Laser Photocoagulation on the Ganglion Cell Complex Thickness in Acute Central Serous Chorioretinopathy
This study investigated the changes in the ganglion cell complex (GCC) of patients with acute central serous chorioretinopathy (CSC) following focal laser photocoagulation (FLP) and sought to determine its correlation with visual acuity (VA). Our retrospective study was conducted on 30 patients diag...
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/4/1064 |
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| author | A Young Lee Jinyoung Choi Sang Un Lee Chul Woo Kim Daniel Duck-Jin Hwang |
| author_facet | A Young Lee Jinyoung Choi Sang Un Lee Chul Woo Kim Daniel Duck-Jin Hwang |
| author_sort | A Young Lee |
| collection | DOAJ |
| description | This study investigated the changes in the ganglion cell complex (GCC) of patients with acute central serous chorioretinopathy (CSC) following focal laser photocoagulation (FLP) and sought to determine its correlation with visual acuity (VA). Our retrospective study was conducted on 30 patients diagnosed with acute CSC between January 2015 and April 2022, who underwent FLP within 3 months of symptom onset. The study assessed GCC changes by measuring the thickness of its inner retinal layers—retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) using optical coherence tomography (OCT). GCC thickness was compared between the affected and unaffected eyes and a healthy control group. VA was also assessed at baseline and at 1, 3, and 6 months post-treatment. VA showed significant improvement from 0.20 ± 0.14 at baseline to 0.10 ± 0.12 logMAR at 6 months post-treatment (<i>p</i> = 0.003). There was no significant change in GCC thickness over the 6-month period. No significant differences in GCC thickness were observed when comparing CSC eyes with fellow eyes or with normal controls at any time point. Final VA was significantly related only to baseline VA, with no correlation found with other factors, including RNFL, GCL, and IPL thickness. In summary, for patients with acute CSC undergoing FLP, our findings indicate that there is no significant change in GCC thickness detectable by OCT before and after the resolution of subretinal fluid (SRF), despite improvements in VA post-laser treatment. This suggests that any potential impact of FLP on GCC thickness may be minimal and not discernible with the current measurement methods, such as OCT, emphasizing that VA improvements may be primarily associated with alterations in the outer retina rather than the inner retina. Further studies with extended follow-up durations are warranted to evaluate any potential long-term changes in GCC. |
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| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-07T22:27:15Z |
| publishDate | 2024-02-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-ff31d05914a04e78b470c9c581b3e8712024-02-23T15:22:11ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01134106410.3390/jcm13041064Effect of Focal Laser Photocoagulation on the Ganglion Cell Complex Thickness in Acute Central Serous ChorioretinopathyA Young Lee0Jinyoung Choi1Sang Un Lee2Chul Woo Kim3Daniel Duck-Jin Hwang4Department of Ophthalmology, Hangil Eye Hospital, Incheon 21388, Republic of KoreaDepartment of Ophthalmology, Hangil Eye Hospital, Incheon 21388, Republic of KoreaDepartment of Ophthalmology, Hangil Eye Hospital, Incheon 21388, Republic of KoreaDepartment of Ophthalmology, Hangil Eye Hospital, Incheon 21388, Republic of KoreaDepartment of Ophthalmology, Hangil Eye Hospital, Incheon 21388, Republic of KoreaThis study investigated the changes in the ganglion cell complex (GCC) of patients with acute central serous chorioretinopathy (CSC) following focal laser photocoagulation (FLP) and sought to determine its correlation with visual acuity (VA). Our retrospective study was conducted on 30 patients diagnosed with acute CSC between January 2015 and April 2022, who underwent FLP within 3 months of symptom onset. The study assessed GCC changes by measuring the thickness of its inner retinal layers—retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) using optical coherence tomography (OCT). GCC thickness was compared between the affected and unaffected eyes and a healthy control group. VA was also assessed at baseline and at 1, 3, and 6 months post-treatment. VA showed significant improvement from 0.20 ± 0.14 at baseline to 0.10 ± 0.12 logMAR at 6 months post-treatment (<i>p</i> = 0.003). There was no significant change in GCC thickness over the 6-month period. No significant differences in GCC thickness were observed when comparing CSC eyes with fellow eyes or with normal controls at any time point. Final VA was significantly related only to baseline VA, with no correlation found with other factors, including RNFL, GCL, and IPL thickness. In summary, for patients with acute CSC undergoing FLP, our findings indicate that there is no significant change in GCC thickness detectable by OCT before and after the resolution of subretinal fluid (SRF), despite improvements in VA post-laser treatment. This suggests that any potential impact of FLP on GCC thickness may be minimal and not discernible with the current measurement methods, such as OCT, emphasizing that VA improvements may be primarily associated with alterations in the outer retina rather than the inner retina. Further studies with extended follow-up durations are warranted to evaluate any potential long-term changes in GCC.https://www.mdpi.com/2077-0383/13/4/1064central serous chorioretinopathyoptical coherence tomographyganglion cell complex |
| spellingShingle | A Young Lee Jinyoung Choi Sang Un Lee Chul Woo Kim Daniel Duck-Jin Hwang Effect of Focal Laser Photocoagulation on the Ganglion Cell Complex Thickness in Acute Central Serous Chorioretinopathy Journal of Clinical Medicine central serous chorioretinopathy optical coherence tomography ganglion cell complex |
| title | Effect of Focal Laser Photocoagulation on the Ganglion Cell Complex Thickness in Acute Central Serous Chorioretinopathy |
| title_full | Effect of Focal Laser Photocoagulation on the Ganglion Cell Complex Thickness in Acute Central Serous Chorioretinopathy |
| title_fullStr | Effect of Focal Laser Photocoagulation on the Ganglion Cell Complex Thickness in Acute Central Serous Chorioretinopathy |
| title_full_unstemmed | Effect of Focal Laser Photocoagulation on the Ganglion Cell Complex Thickness in Acute Central Serous Chorioretinopathy |
| title_short | Effect of Focal Laser Photocoagulation on the Ganglion Cell Complex Thickness in Acute Central Serous Chorioretinopathy |
| title_sort | effect of focal laser photocoagulation on the ganglion cell complex thickness in acute central serous chorioretinopathy |
| topic | central serous chorioretinopathy optical coherence tomography ganglion cell complex |
| url | https://www.mdpi.com/2077-0383/13/4/1064 |
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