A CMOS integrated impedance-to-frequency converter for sensing cellular adhesion
Sensing cellular adhesion via impedance measurements provides a versatile and easily accessible means for monitoring in-vitro cell cultures. Previous works used external electronics connected via cables to microelectrodes to achieve this goal, thus incurring parasitic impedance, electromagnetic inte...
| Main Authors: | , , |
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| Format: | Article |
| Language: | deu |
| Published: |
Copernicus Publications
2011-08-01
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| Series: | Advances in Radio Science |
| Online Access: | http://www.adv-radio-sci.net/9/281/2011/ars-9-281-2011.pdf |
| Summary: | Sensing cellular adhesion via impedance measurements provides a versatile and
easily accessible means for monitoring in-vitro cell cultures. Previous works
used external electronics connected via cables to microelectrodes to achieve
this goal, thus incurring parasitic impedance, electromagnetic interference,
and bulky measurement setups. In this work we present a CMOS
impedance-to-frequency converter integrated with biocompatible planar surface
electrodes to make a compact and robust sensor chip for in-vitro cell
monitoring. The system features an 8×8 array of individually
addressable electrodes connected to four impedance-to-frequency converter
circuits with externally adjustable biasing and square wave output. We
present first measurement results obtained with the integrated electronics
that demonstrate the successful operation of the system and show good
agreement with models of the electrode and cell impedances. |
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| ISSN: | 1684-9965 1684-9973 |