Atypical femoral neck fracture after prolonged bisphosphonate therapy
Of the drugs developed to prevent and treat osteoporosis, bisphosphonate has played a very important role in preventing osteoporotic fractures. However, case reports describing atypical femoral fractures in patients using long-term bisphosphonates have emerged. The majority of atypical femur fractur...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Pathologists & the Korean Society for Cytopathology
2020-07-01
|
| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2020-05-14.pdf |
| _version_ | 1828445499880898560 |
|---|---|
| author | Kwang-kyoun Kim Young-wook Park Tae-hyeong Kim Kyung-deok Seo |
| author_facet | Kwang-kyoun Kim Young-wook Park Tae-hyeong Kim Kyung-deok Seo |
| author_sort | Kwang-kyoun Kim |
| collection | DOAJ |
| description | Of the drugs developed to prevent and treat osteoporosis, bisphosphonate has played a very important role in preventing osteoporotic fractures. However, case reports describing atypical femoral fractures in patients using long-term bisphosphonates have emerged. The majority of atypical femur fractures occurs in the lateral aspect of the subtrochanteric or femur diaphysis, which is explained by accumulation of tensile stress in these areas. Although the superior cortex of the femur neck withstands maximum tensile stress, to our knowledge, there have been only two reports (three cases) of atypical femoral neck fracture. In addition, none of those case reports revealed detailed pathology related to suppressed bone turnover rate. We encountered an incomplete femoral neck fracture and diagnosed it as “atypical” on the basis of the patient’s lack of trauma and medication history and pathological findings. For patients with groin pain, minimal or no trauma, and a history of long-term bisphosphonate use, an atypical femoral neck fracture should be considered. |
| first_indexed | 2024-12-10T21:58:57Z |
| format | Article |
| id | doaj.art-ff322fb3aa5b4ff9af17f6fcf007a05a |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-10T21:58:57Z |
| publishDate | 2020-07-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-ff322fb3aa5b4ff9af17f6fcf007a05a2022-12-22T01:31:58ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452020-07-0154434635010.4132/jptm.2020.05.1416917Atypical femoral neck fracture after prolonged bisphosphonate therapyKwang-kyoun Kim0Young-wook Park1Tae-hyeong Kim2Kyung-deok Seo3 Department of Orthopaedic Surgery, Konyang Unversity Hospital, Daejeon, Korea Department of Pathology, Konyang Unversity Hospital, Daejeon, Korea Department of Orthopaedic Surgery, Konyang Unversity Hospital, Daejeon, Korea Department of Orthopaedic Surgery, Konyang Unversity Hospital, Daejeon, KoreaOf the drugs developed to prevent and treat osteoporosis, bisphosphonate has played a very important role in preventing osteoporotic fractures. However, case reports describing atypical femoral fractures in patients using long-term bisphosphonates have emerged. The majority of atypical femur fractures occurs in the lateral aspect of the subtrochanteric or femur diaphysis, which is explained by accumulation of tensile stress in these areas. Although the superior cortex of the femur neck withstands maximum tensile stress, to our knowledge, there have been only two reports (three cases) of atypical femoral neck fracture. In addition, none of those case reports revealed detailed pathology related to suppressed bone turnover rate. We encountered an incomplete femoral neck fracture and diagnosed it as “atypical” on the basis of the patient’s lack of trauma and medication history and pathological findings. For patients with groin pain, minimal or no trauma, and a history of long-term bisphosphonate use, an atypical femoral neck fracture should be considered.http://www.jpatholtm.org/upload/pdf/jptm-2020-05-14.pdfatypical femur fracturefemur neck fracturetensile strengthbisphosphonate |
| spellingShingle | Kwang-kyoun Kim Young-wook Park Tae-hyeong Kim Kyung-deok Seo Atypical femoral neck fracture after prolonged bisphosphonate therapy Journal of Pathology and Translational Medicine atypical femur fracture femur neck fracture tensile strength bisphosphonate |
| title | Atypical femoral neck fracture after prolonged bisphosphonate therapy |
| title_full | Atypical femoral neck fracture after prolonged bisphosphonate therapy |
| title_fullStr | Atypical femoral neck fracture after prolonged bisphosphonate therapy |
| title_full_unstemmed | Atypical femoral neck fracture after prolonged bisphosphonate therapy |
| title_short | Atypical femoral neck fracture after prolonged bisphosphonate therapy |
| title_sort | atypical femoral neck fracture after prolonged bisphosphonate therapy |
| topic | atypical femur fracture femur neck fracture tensile strength bisphosphonate |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2020-05-14.pdf |
| work_keys_str_mv | AT kwangkyounkim atypicalfemoralneckfractureafterprolongedbisphosphonatetherapy AT youngwookpark atypicalfemoralneckfractureafterprolongedbisphosphonatetherapy AT taehyeongkim atypicalfemoralneckfractureafterprolongedbisphosphonatetherapy AT kyungdeokseo atypicalfemoralneckfractureafterprolongedbisphosphonatetherapy |