Resveratrol Attenuates High Glucose-Induced Osteoblast Dysfunction via AKT/GSK3β/FYN-Mediated NRF2 Activation

Resveratrol Attenuates High Glucose-Induced Osteoblast Dysfunction via AKT/GSK3β/FYN-Mediated NRF2 Activation

Osteoblast dysfunction, induced by high glucose (HG), negatively impacts bone homeostasis and contributes to the pathology of diabetic osteoporosis (DOP). One of the most widely recognized mechanisms for osteoblast dysfunction is oxidative stress. Resveratrol (RES) is a bioactive antioxidant compoun...

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Bibliographic Details
Main Authors:	Yue Xuan, Jie Wang, Xiaohui Zhang, Jiahao Li, Qingbo Liu, Guangping Lu, Mengjie Xiao, Ting Gao, Yuanfang Guo, Cong Cao, Ou Chen, Kunli Wang, Yufeng Tang, Junlian Gu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-05-01
Series:	Frontiers in Pharmacology
Subjects:	resveratrol diabetes osteoblast dysfunction oxidative stress NRF2
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.862618/full

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