Suppression of Glucagon-Like Peptide-1 Release by Inhibition of Intestinal NLRP3 Inflammasome Activation in Asc–/– and Nlrp3–/– Mice

Suppression of Glucagon-Like Peptide-1 Release by Inhibition of Intestinal NLRP3 Inflammasome Activation in Asc–/– and Nlrp3–/– Mice

The glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone secreted by intestinal enteroendocrine L-cells, which plays a crucial role in glucose control, regulation, and protection from different pathological conditions such as diabetes mellitus. The present study sought to test whether GLP-1...

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Bibliographic Details
Main Authors: Yu Chen, Jason Kidd, Owais M. Bhat, Xinxu Yuan, Jinni Hong, Xingxiang He, Pin-Lan Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Physiology
Subjects:
GLP-1
NLRP3
inflammasome
IL-1β
HMGB1
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01213/full

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