New Antimicrobial Strategies Based on Metal Complexes
Traditional organic antimicrobials mainly act on specific biochemical processes such as replication, transcription and translation. However, the emergence and wide spread of microbial resistance is a growing threat for human beings. Therefore, it is highly necessary to design strategies for the deve...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Chemistry |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-8549/2/4/56 |
| _version_ | 1797550834905513984 |
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| author | Mickaël Claudel Justine V. Schwarte Katharina M. Fromm |
| author_facet | Mickaël Claudel Justine V. Schwarte Katharina M. Fromm |
| author_sort | Mickaël Claudel |
| collection | DOAJ |
| description | Traditional organic antimicrobials mainly act on specific biochemical processes such as replication, transcription and translation. However, the emergence and wide spread of microbial resistance is a growing threat for human beings. Therefore, it is highly necessary to design strategies for the development of new drugs in order to target multiple cellular processes that should improve their efficiency against several microorganisms, including bacteria, viruses or fungi. The present review is focused on recent advances and findings of new antimicrobial strategies based on metal complexes. Recent studies indicate that some metal ions cause different types of damages to microbial cells as a result of membrane degradation, protein dysfunction and oxidative stress. These unique modes of action, combined with the wide range of three-dimensional geometries that metal complexes can adopt, make them suitable for the development of new antimicrobial drugs. |
| first_indexed | 2024-03-10T15:35:05Z |
| format | Article |
| id | doaj.art-ff335ac08645475eab29e282a3a82b91 |
| institution | Directory Open Access Journal |
| issn | 2624-8549 |
| language | English |
| last_indexed | 2024-03-10T15:35:05Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry |
| spelling | doaj.art-ff335ac08645475eab29e282a3a82b912023-11-20T17:20:47ZengMDPI AGChemistry2624-85492020-10-012484989910.3390/chemistry2040056New Antimicrobial Strategies Based on Metal ComplexesMickaël Claudel0Justine V. Schwarte1Katharina M. Fromm2Department of Chemistry, University of Fribourg, Chemin du Musée 9, CH-1700 Fribourg, SwitzerlandDepartment of Chemistry, University of Fribourg, Chemin du Musée 9, CH-1700 Fribourg, SwitzerlandDepartment of Chemistry, University of Fribourg, Chemin du Musée 9, CH-1700 Fribourg, SwitzerlandTraditional organic antimicrobials mainly act on specific biochemical processes such as replication, transcription and translation. However, the emergence and wide spread of microbial resistance is a growing threat for human beings. Therefore, it is highly necessary to design strategies for the development of new drugs in order to target multiple cellular processes that should improve their efficiency against several microorganisms, including bacteria, viruses or fungi. The present review is focused on recent advances and findings of new antimicrobial strategies based on metal complexes. Recent studies indicate that some metal ions cause different types of damages to microbial cells as a result of membrane degradation, protein dysfunction and oxidative stress. These unique modes of action, combined with the wide range of three-dimensional geometries that metal complexes can adopt, make them suitable for the development of new antimicrobial drugs.https://www.mdpi.com/2624-8549/2/4/56metal complexesnew antimicrobial strategiesmetallo-drugssilvercopperzinc |
| spellingShingle | Mickaël Claudel Justine V. Schwarte Katharina M. Fromm New Antimicrobial Strategies Based on Metal Complexes Chemistry metal complexes new antimicrobial strategies metallo-drugs silver copper zinc |
| title | New Antimicrobial Strategies Based on Metal Complexes |
| title_full | New Antimicrobial Strategies Based on Metal Complexes |
| title_fullStr | New Antimicrobial Strategies Based on Metal Complexes |
| title_full_unstemmed | New Antimicrobial Strategies Based on Metal Complexes |
| title_short | New Antimicrobial Strategies Based on Metal Complexes |
| title_sort | new antimicrobial strategies based on metal complexes |
| topic | metal complexes new antimicrobial strategies metallo-drugs silver copper zinc |
| url | https://www.mdpi.com/2624-8549/2/4/56 |
| work_keys_str_mv | AT mickaelclaudel newantimicrobialstrategiesbasedonmetalcomplexes AT justinevschwarte newantimicrobialstrategiesbasedonmetalcomplexes AT katharinamfromm newantimicrobialstrategiesbasedonmetalcomplexes |