Effectiveness of Pulmonary Rehabilitation among COVID-19 Patients: A Systematic Review and Meta-Analysis
Background: Many COVID-19 patients presented with detrimental features, such as impaired respiratory function, physical capacity, and overall poor quality of life. The present study evaluates the effectiveness of pulmonary rehabilitation on COVID-19 patients. Methods: We searched PubMed, Scopus, Sci...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-10-01
|
| Series: | Healthcare |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9032/10/11/2130 |
| _version_ | 1797468193835450368 |
|---|---|
| author | Sameer Badri AL-Mhanna Mahaneem Mohamed Norhayati Mohd Noor Hafeez Abiola Afolabi Ahmad Adebayo Irekeola Kizito Eneye Bello Monira I. Aldhahi Wan Syaheedah Wan Ghazali |
| author_facet | Sameer Badri AL-Mhanna Mahaneem Mohamed Norhayati Mohd Noor Hafeez Abiola Afolabi Ahmad Adebayo Irekeola Kizito Eneye Bello Monira I. Aldhahi Wan Syaheedah Wan Ghazali |
| author_sort | Sameer Badri AL-Mhanna |
| collection | DOAJ |
| description | Background: Many COVID-19 patients presented with detrimental features, such as impaired respiratory function, physical capacity, and overall poor quality of life. The present study evaluates the effectiveness of pulmonary rehabilitation on COVID-19 patients. Methods: We searched PubMed, Scopus, ScienceDirect, and Google Scholar from 2019 to 2021. The protocol was registered in PROSPERO with the registration number CRD42021273618. We performed statistical analyses via random effects and expressed the outcomes as standardized mean difference (SMD) for continuous variables, with 95% confidence intervals (CI). Results: We included six trials involving 432 patients. The primary outcome showed a significant improvement in physical function (SMD 0.83, 95% CI −0.58 to 1.09; <i>p</i> < 0.001; four trials, 266 participants; high-quality evidence). There was significant difference in anxiety (SMD −0.80, 95% CI −1.23 to −0.37; <i>p</i> = 0.003), physical activity intensity levels (SMD −1.27, 95% CI −2.23 to −0.32; <i>p</i> = 0.009), sleep quality (MD −0.05, 95% CI −0.83 to −0.16; <i>p</i> = 0.004), peripheral muscle performance of lower limbs (SMD 0.90, 95% CI −0.60 to 1.20; <i>p</i> < 0.001), and dyspnoea outcomes (SMD −0.55, 95% CI −0.87 to −0.23; <i>p</i> = 0.007). Conclusions: Pulmonary rehabilitation is an effective adjuvant therapy that minimizes COVID-19 severity in the intervention group compared to the conventional treatment. The findings of this study will need to be considered in the framework of the clinical outcome as observed in the intervention outcome. Additionally, safer data on guideline rehabilitation would be needed to examine whether pulmonary rehabilitation would be a fruitful intervention to reduce COVID-19 severity. |
| first_indexed | 2024-03-09T19:03:07Z |
| format | Article |
| id | doaj.art-ff3370c88d0e4618b42578f6f01bfee2 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-09T19:03:07Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-ff3370c88d0e4618b42578f6f01bfee22023-11-24T04:50:17ZengMDPI AGHealthcare2227-90322022-10-011011213010.3390/healthcare10112130Effectiveness of Pulmonary Rehabilitation among COVID-19 Patients: A Systematic Review and Meta-AnalysisSameer Badri AL-Mhanna0Mahaneem Mohamed1Norhayati Mohd Noor2Hafeez Abiola Afolabi3Ahmad Adebayo Irekeola4Kizito Eneye Bello5Monira I. Aldhahi6Wan Syaheedah Wan Ghazali7Department of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Family Medicine, School of Medical Sciences, Kubang Kerian 16150, MalaysiaDepartment of General Surgery, School of Medical Sciences, Hospital University Sains Malaysia HUSM, University Sains Malaysia USM, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaDepartment of Microbiology, Kogi State University (Prince Abubakar Audu University), Anyigba 272102, NigeriaDepartment of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi ArabiaDepartment of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang Kerian 16150, Kelantan, MalaysiaBackground: Many COVID-19 patients presented with detrimental features, such as impaired respiratory function, physical capacity, and overall poor quality of life. The present study evaluates the effectiveness of pulmonary rehabilitation on COVID-19 patients. Methods: We searched PubMed, Scopus, ScienceDirect, and Google Scholar from 2019 to 2021. The protocol was registered in PROSPERO with the registration number CRD42021273618. We performed statistical analyses via random effects and expressed the outcomes as standardized mean difference (SMD) for continuous variables, with 95% confidence intervals (CI). Results: We included six trials involving 432 patients. The primary outcome showed a significant improvement in physical function (SMD 0.83, 95% CI −0.58 to 1.09; <i>p</i> < 0.001; four trials, 266 participants; high-quality evidence). There was significant difference in anxiety (SMD −0.80, 95% CI −1.23 to −0.37; <i>p</i> = 0.003), physical activity intensity levels (SMD −1.27, 95% CI −2.23 to −0.32; <i>p</i> = 0.009), sleep quality (MD −0.05, 95% CI −0.83 to −0.16; <i>p</i> = 0.004), peripheral muscle performance of lower limbs (SMD 0.90, 95% CI −0.60 to 1.20; <i>p</i> < 0.001), and dyspnoea outcomes (SMD −0.55, 95% CI −0.87 to −0.23; <i>p</i> = 0.007). Conclusions: Pulmonary rehabilitation is an effective adjuvant therapy that minimizes COVID-19 severity in the intervention group compared to the conventional treatment. The findings of this study will need to be considered in the framework of the clinical outcome as observed in the intervention outcome. Additionally, safer data on guideline rehabilitation would be needed to examine whether pulmonary rehabilitation would be a fruitful intervention to reduce COVID-19 severity.https://www.mdpi.com/2227-9032/10/11/2130SARS-COVID-19coronal virus diseaselong COVIDexercisephysical activity |
| spellingShingle | Sameer Badri AL-Mhanna Mahaneem Mohamed Norhayati Mohd Noor Hafeez Abiola Afolabi Ahmad Adebayo Irekeola Kizito Eneye Bello Monira I. Aldhahi Wan Syaheedah Wan Ghazali Effectiveness of Pulmonary Rehabilitation among COVID-19 Patients: A Systematic Review and Meta-Analysis Healthcare SARS-COVID-19 coronal virus disease long COVID exercise physical activity |
| title | Effectiveness of Pulmonary Rehabilitation among COVID-19 Patients: A Systematic Review and Meta-Analysis |
| title_full | Effectiveness of Pulmonary Rehabilitation among COVID-19 Patients: A Systematic Review and Meta-Analysis |
| title_fullStr | Effectiveness of Pulmonary Rehabilitation among COVID-19 Patients: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Effectiveness of Pulmonary Rehabilitation among COVID-19 Patients: A Systematic Review and Meta-Analysis |
| title_short | Effectiveness of Pulmonary Rehabilitation among COVID-19 Patients: A Systematic Review and Meta-Analysis |
| title_sort | effectiveness of pulmonary rehabilitation among covid 19 patients a systematic review and meta analysis |
| topic | SARS-COVID-19 coronal virus disease long COVID exercise physical activity |
| url | https://www.mdpi.com/2227-9032/10/11/2130 |
| work_keys_str_mv | AT sameerbadrialmhanna effectivenessofpulmonaryrehabilitationamongcovid19patientsasystematicreviewandmetaanalysis AT mahaneemmohamed effectivenessofpulmonaryrehabilitationamongcovid19patientsasystematicreviewandmetaanalysis AT norhayatimohdnoor effectivenessofpulmonaryrehabilitationamongcovid19patientsasystematicreviewandmetaanalysis AT hafeezabiolaafolabi effectivenessofpulmonaryrehabilitationamongcovid19patientsasystematicreviewandmetaanalysis AT ahmadadebayoirekeola effectivenessofpulmonaryrehabilitationamongcovid19patientsasystematicreviewandmetaanalysis AT kizitoeneyebello effectivenessofpulmonaryrehabilitationamongcovid19patientsasystematicreviewandmetaanalysis AT moniraialdhahi effectivenessofpulmonaryrehabilitationamongcovid19patientsasystematicreviewandmetaanalysis AT wansyaheedahwanghazali effectivenessofpulmonaryrehabilitationamongcovid19patientsasystematicreviewandmetaanalysis |