Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study
Naomichi Okamoto,1 Keita Watanabe,2 LeHoa Ngyuyen,1,3 Atsuko Ikenouchi,1 Taro Kishi,4 Nakao Iwata,4 Shingo Kakeda,5 Yukunori Korogi,6 Reiji Yoshimura1 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan; 2Open Innovation Institute, Kyoto University, Kyot...
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| Format: | Article |
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Dove Medical Press
2020-10-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/association-of-serum-kynurenine-levels-and-neural-networks-in-patients-peer-reviewed-article-NDT |
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| author | Okamoto N Watanabe K Ngyuyen LH Ikenouchi A Kishi T Iwata N Kakeda S Korogi Y Yoshimura R |
| author_facet | Okamoto N Watanabe K Ngyuyen LH Ikenouchi A Kishi T Iwata N Kakeda S Korogi Y Yoshimura R |
| author_sort | Okamoto N |
| collection | DOAJ |
| description | Naomichi Okamoto,1 Keita Watanabe,2 LeHoa Ngyuyen,1,3 Atsuko Ikenouchi,1 Taro Kishi,4 Nakao Iwata,4 Shingo Kakeda,5 Yukunori Korogi,6 Reiji Yoshimura1 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan; 2Open Innovation Institute, Kyoto University, Kyoto, Japan; 3School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam; 4Department of Psychiatry, Fujita Medical University, Toyoake, Japan; 5Department of Radiology, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan; 6Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, JapanCorrespondence: Reiji YoshimuraDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, JapanTel +81 936917253Email yoshi621@med.uoeh-u.ac.jpPurpose: The kynurenine (KYN) pathway can directly or indirectly influence cerebral volume and neural integrity in patients with major depression (MD). The aim of the present study was to investigate neural network systems and the KYN pathway in patients with first-episode, drug-naïve MD.Patients and Methods: Twenty right-handed drug-naïve patients, with MD diagnosed using the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision, Research Version, were included in this study. Magnetic resonance imaging scans and scores on the Hamilton Rating Scale for Depression were assessed, and serum sampling was performed prior to the start of pharmacological treatment. Image processing and data analysis were performed according to our recently published procedure. Serum metabolomes were measured in the cation and anion modes of CE-FTMS-based metabolome analysis.Results: We found that serum KYN levels were positively correlated with the Z-scores of the salience network but not with those of the central executive network or default mode network. No associations were observed between serum glutamate levels and the Z-score of any of the three networks.Conclusion: Our results indicate that serum KYN levels might affect the activity of the salience network in first-episode, drug-naïve patients with MD.Keywords: kynurenine, major depression, neural network, source-based morphometry |
| first_indexed | 2024-12-14T13:44:55Z |
| format | Article |
| id | doaj.art-ff33dc5428f34cfe815c9fb76c2675cd |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-14T13:44:55Z |
| publishDate | 2020-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-ff33dc5428f34cfe815c9fb76c2675cd2022-12-21T22:59:21ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212020-10-01Volume 162569257758712Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry StudyOkamoto NWatanabe KNgyuyen LHIkenouchi AKishi TIwata NKakeda SKorogi YYoshimura RNaomichi Okamoto,1 Keita Watanabe,2 LeHoa Ngyuyen,1,3 Atsuko Ikenouchi,1 Taro Kishi,4 Nakao Iwata,4 Shingo Kakeda,5 Yukunori Korogi,6 Reiji Yoshimura1 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan; 2Open Innovation Institute, Kyoto University, Kyoto, Japan; 3School of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam; 4Department of Psychiatry, Fujita Medical University, Toyoake, Japan; 5Department of Radiology, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan; 6Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, JapanCorrespondence: Reiji YoshimuraDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, JapanTel +81 936917253Email yoshi621@med.uoeh-u.ac.jpPurpose: The kynurenine (KYN) pathway can directly or indirectly influence cerebral volume and neural integrity in patients with major depression (MD). The aim of the present study was to investigate neural network systems and the KYN pathway in patients with first-episode, drug-naïve MD.Patients and Methods: Twenty right-handed drug-naïve patients, with MD diagnosed using the Diagnostic and Statistical Manual for Mental Disorders, Fourth Edition, Text Revision, Research Version, were included in this study. Magnetic resonance imaging scans and scores on the Hamilton Rating Scale for Depression were assessed, and serum sampling was performed prior to the start of pharmacological treatment. Image processing and data analysis were performed according to our recently published procedure. Serum metabolomes were measured in the cation and anion modes of CE-FTMS-based metabolome analysis.Results: We found that serum KYN levels were positively correlated with the Z-scores of the salience network but not with those of the central executive network or default mode network. No associations were observed between serum glutamate levels and the Z-score of any of the three networks.Conclusion: Our results indicate that serum KYN levels might affect the activity of the salience network in first-episode, drug-naïve patients with MD.Keywords: kynurenine, major depression, neural network, source-based morphometryhttps://www.dovepress.com/association-of-serum-kynurenine-levels-and-neural-networks-in-patients-peer-reviewed-article-NDTkynureninemajor depressionneural networksource-based morphometry |
| spellingShingle | Okamoto N Watanabe K Ngyuyen LH Ikenouchi A Kishi T Iwata N Kakeda S Korogi Y Yoshimura R Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study Neuropsychiatric Disease and Treatment kynurenine major depression neural network source-based morphometry |
| title | Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study |
| title_full | Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study |
| title_fullStr | Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study |
| title_full_unstemmed | Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study |
| title_short | Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study |
| title_sort | association of serum kynurenine levels and neural networks in patients with first episode drug na iuml ve major depression a source based morphometry study |
| topic | kynurenine major depression neural network source-based morphometry |
| url | https://www.dovepress.com/association-of-serum-kynurenine-levels-and-neural-networks-in-patients-peer-reviewed-article-NDT |
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