Glucocorticoid-Induced Leucine Zipper Inhibits Interferon-Gamma Production in B Cells and Suppresses Colitis in Mice

Glucocorticoid-Induced Leucine Zipper Inhibits Interferon-Gamma Production in B Cells and Suppresses Colitis in Mice

Glucocorticoid-induced leucine zipper (GILZ) is transcriptionally upregulated by glucocorticoids (GCs) and mediates many of the anti-inflammatory effects of GCs. Since B cell activity has been linked to cytokine production and modulation of inflammatory responses, we herein investigated the role of...

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Bibliographic Details
Main Authors: Stefano Bruscoli, Daniele Sorcini, Sara Flamini, Andrea Gagliardi, Francesco Adamo, Simona Ronchetti, Graziella Migliorati, Oxana Bereshchenko, Carlo Riccardi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
corticosteroid
glucocorticoid-induced leucine zipper
inflammation
IFN-γ
mouse models
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01720/full

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