Blood Glucose and Lactate Levels and Cerebral Oxygenation in Preterm and Term Neonates—A Systematic Qualitative Review of the Literature
Background: Cerebral oxygenation monitored non-invasively by near-infrared spectroscopy (NIRS) is of increasing interest in neonatal care. Cerebral oxygenation is determined by cerebral oxygen delivery and cerebral oxygen consumption. Oxygen delivery as well as oxygen consumption might be influenced...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2020.00361/full |
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| author | Christian Mattersberger Christian Mattersberger Georg M. Schmölzer Georg M. Schmölzer Berndt Urlesberger Berndt Urlesberger Gerhard Pichler Gerhard Pichler |
| author_facet | Christian Mattersberger Christian Mattersberger Georg M. Schmölzer Georg M. Schmölzer Berndt Urlesberger Berndt Urlesberger Gerhard Pichler Gerhard Pichler |
| author_sort | Christian Mattersberger |
| collection | DOAJ |
| description | Background: Cerebral oxygenation monitored non-invasively by near-infrared spectroscopy (NIRS) is of increasing interest in neonatal care. Cerebral oxygenation is determined by cerebral oxygen delivery and cerebral oxygen consumption. Oxygen delivery as well as oxygen consumption might be influenced by metabolic parameters like blood glucose and lactate.Objective: The aim of the present systematic qualitative review is therefore to identify and summarize all studies, which describe cerebral oxygenation measured with NIRS and blood glucose and/or blood lactate levels in neonates.Data sources: A systematic search of Ovid Embase and PubMed was performed. Search terms included near-infrared spectroscopy, fractional tissue oxygen extraction, cerebral tissue oxygen saturation, regional cerebral tissue oxygen saturation, oxygenation, term, and preterm neonates, cesarean delivery, transition, after-birth, newborn, vaginal delivery, cesarean delivery, baby, neonatal transition, metabolism, lactate, glucose, and blood glucose level.Study selection/data synthesis: Studies analyzing cerebral oxygenation and blood glucose and/or blood lactate levels in neonates were included. Animal studies, duplicates, or studies in non-English language were excluded.Results: Twenty-five studies were identified that describe blood glucose and/or blood lactate levels as primary or secondary outcome parameters with additional measured cerebral oxygenation by NIRS in neonates. Twelve studies were included with blood glucose measurements: four described an association between blood glucose levels and cerebral oxygenation, two show no association, and six do not report on possible associations. Eighteen studies were included with lactate measurements: one describe an association between lactate levels and cerebral oxygenation, while three show no association and 14 do not report on possible associations.Discussion: The influence of blood glucose and blood lactate levels on the cerebral oxygenation in neonates is still controversial. However, there seems to be an association between cerebral oxygenation and the metabolic parameter blood glucose and lactate, which need further investigation. |
| first_indexed | 2024-12-11T00:23:54Z |
| format | Article |
| id | doaj.art-ff36bcef5d2345149171c760422f4e78 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-11T00:23:54Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-ff36bcef5d2345149171c760422f4e782022-12-22T01:27:38ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-07-01810.3389/fped.2020.00361540688Blood Glucose and Lactate Levels and Cerebral Oxygenation in Preterm and Term Neonates—A Systematic Qualitative Review of the LiteratureChristian Mattersberger0Christian Mattersberger1Georg M. Schmölzer2Georg M. Schmölzer3Berndt Urlesberger4Berndt Urlesberger5Gerhard Pichler6Gerhard Pichler7Division of Neonatology, Department of Paediatrics, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Department of Paediatrics, Medical University of Graz, Graz, AustriaCentre for the Studies of Asphyxia and Resuscitation, Royal Alexandra Hospital, Edmonton, AB, CanadaDepartment of Pediatrics, University of Alberta, Edmonton, AB, CanadaDivision of Neonatology, Department of Paediatrics, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Department of Paediatrics, Medical University of Graz, Graz, AustriaDivision of Neonatology, Department of Paediatrics, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Department of Paediatrics, Medical University of Graz, Graz, AustriaBackground: Cerebral oxygenation monitored non-invasively by near-infrared spectroscopy (NIRS) is of increasing interest in neonatal care. Cerebral oxygenation is determined by cerebral oxygen delivery and cerebral oxygen consumption. Oxygen delivery as well as oxygen consumption might be influenced by metabolic parameters like blood glucose and lactate.Objective: The aim of the present systematic qualitative review is therefore to identify and summarize all studies, which describe cerebral oxygenation measured with NIRS and blood glucose and/or blood lactate levels in neonates.Data sources: A systematic search of Ovid Embase and PubMed was performed. Search terms included near-infrared spectroscopy, fractional tissue oxygen extraction, cerebral tissue oxygen saturation, regional cerebral tissue oxygen saturation, oxygenation, term, and preterm neonates, cesarean delivery, transition, after-birth, newborn, vaginal delivery, cesarean delivery, baby, neonatal transition, metabolism, lactate, glucose, and blood glucose level.Study selection/data synthesis: Studies analyzing cerebral oxygenation and blood glucose and/or blood lactate levels in neonates were included. Animal studies, duplicates, or studies in non-English language were excluded.Results: Twenty-five studies were identified that describe blood glucose and/or blood lactate levels as primary or secondary outcome parameters with additional measured cerebral oxygenation by NIRS in neonates. Twelve studies were included with blood glucose measurements: four described an association between blood glucose levels and cerebral oxygenation, two show no association, and six do not report on possible associations. Eighteen studies were included with lactate measurements: one describe an association between lactate levels and cerebral oxygenation, while three show no association and 14 do not report on possible associations.Discussion: The influence of blood glucose and blood lactate levels on the cerebral oxygenation in neonates is still controversial. However, there seems to be an association between cerebral oxygenation and the metabolic parameter blood glucose and lactate, which need further investigation.https://www.frontiersin.org/article/10.3389/fped.2020.00361/fullneonatesblood glucoselactatenear-infrared spectroscopycerebral oxygenation |
| spellingShingle | Christian Mattersberger Christian Mattersberger Georg M. Schmölzer Georg M. Schmölzer Berndt Urlesberger Berndt Urlesberger Gerhard Pichler Gerhard Pichler Blood Glucose and Lactate Levels and Cerebral Oxygenation in Preterm and Term Neonates—A Systematic Qualitative Review of the Literature Frontiers in Pediatrics neonates blood glucose lactate near-infrared spectroscopy cerebral oxygenation |
| title | Blood Glucose and Lactate Levels and Cerebral Oxygenation in Preterm and Term Neonates—A Systematic Qualitative Review of the Literature |
| title_full | Blood Glucose and Lactate Levels and Cerebral Oxygenation in Preterm and Term Neonates—A Systematic Qualitative Review of the Literature |
| title_fullStr | Blood Glucose and Lactate Levels and Cerebral Oxygenation in Preterm and Term Neonates—A Systematic Qualitative Review of the Literature |
| title_full_unstemmed | Blood Glucose and Lactate Levels and Cerebral Oxygenation in Preterm and Term Neonates—A Systematic Qualitative Review of the Literature |
| title_short | Blood Glucose and Lactate Levels and Cerebral Oxygenation in Preterm and Term Neonates—A Systematic Qualitative Review of the Literature |
| title_sort | blood glucose and lactate levels and cerebral oxygenation in preterm and term neonates a systematic qualitative review of the literature |
| topic | neonates blood glucose lactate near-infrared spectroscopy cerebral oxygenation |
| url | https://www.frontiersin.org/article/10.3389/fped.2020.00361/full |
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