First Evidence of a Combination of Terpinen-4-ol and α-Terpineol as a Promising Tool against ESKAPE Pathogens
Antimicrobial resistance is a major public health issue raising growing concern in the face of dwindling response options. It is therefore urgent to find new anti-infective molecules enabling us to fight effectively against ever more numerous bacterial infections caused by ever more antibiotic-resis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/21/7472 |
| _version_ | 1797467078360301568 |
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| author | Bianca Johansen Raphaël E. Duval Jean-Christophe Sergere |
| author_facet | Bianca Johansen Raphaël E. Duval Jean-Christophe Sergere |
| author_sort | Bianca Johansen |
| collection | DOAJ |
| description | Antimicrobial resistance is a major public health issue raising growing concern in the face of dwindling response options. It is therefore urgent to find new anti-infective molecules enabling us to fight effectively against ever more numerous bacterial infections caused by ever more antibiotic-resistant bacteria. In this quest for new antibacterials, essential oils (or compounds extracted from essential oils) appear to be a promising therapeutic option. In the present work, we investigate the potential antibacterial synergy between a combination of terpinen-4-ol and α-terpineol (10:1) compared to standard tea tree oil. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined. Then, time kill assays, in vitro cytotoxicity and bactericidal activity on latent bacteria (persisters) were investigated. Finally, an in silico study of the pharmacokinetic parameters of α-terpineol was also performed. Altogether, our data demonstrate that the combination of terpinen-4-ol and α-terpineol might be a precious weapon to address ESKAPE pathogens. |
| first_indexed | 2024-03-09T18:48:32Z |
| format | Article |
| id | doaj.art-ff37624bb55a47b78ffae1827e305862 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:48:32Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ff37624bb55a47b78ffae1827e3058622023-11-24T06:04:46ZengMDPI AGMolecules1420-30492022-11-012721747210.3390/molecules27217472First Evidence of a Combination of Terpinen-4-ol and α-Terpineol as a Promising Tool against ESKAPE PathogensBianca Johansen0Raphaël E. Duval1Jean-Christophe Sergere2SETUBIO SA, Naturopole, F-03800 Saint Bonnet de Rochefort, FranceUniversité de Lorraine, CNRS, L2CM, F-54000 Nancy, FranceSETUBIO SA, Naturopole, F-03800 Saint Bonnet de Rochefort, FranceAntimicrobial resistance is a major public health issue raising growing concern in the face of dwindling response options. It is therefore urgent to find new anti-infective molecules enabling us to fight effectively against ever more numerous bacterial infections caused by ever more antibiotic-resistant bacteria. In this quest for new antibacterials, essential oils (or compounds extracted from essential oils) appear to be a promising therapeutic option. In the present work, we investigate the potential antibacterial synergy between a combination of terpinen-4-ol and α-terpineol (10:1) compared to standard tea tree oil. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined. Then, time kill assays, in vitro cytotoxicity and bactericidal activity on latent bacteria (persisters) were investigated. Finally, an in silico study of the pharmacokinetic parameters of α-terpineol was also performed. Altogether, our data demonstrate that the combination of terpinen-4-ol and α-terpineol might be a precious weapon to address ESKAPE pathogens.https://www.mdpi.com/1420-3049/27/21/7472tea tree oilterpinen-4-olα-terpineolantibacterial activitysynergycytotoxicity |
| spellingShingle | Bianca Johansen Raphaël E. Duval Jean-Christophe Sergere First Evidence of a Combination of Terpinen-4-ol and α-Terpineol as a Promising Tool against ESKAPE Pathogens Molecules tea tree oil terpinen-4-ol α-terpineol antibacterial activity synergy cytotoxicity |
| title | First Evidence of a Combination of Terpinen-4-ol and α-Terpineol as a Promising Tool against ESKAPE Pathogens |
| title_full | First Evidence of a Combination of Terpinen-4-ol and α-Terpineol as a Promising Tool against ESKAPE Pathogens |
| title_fullStr | First Evidence of a Combination of Terpinen-4-ol and α-Terpineol as a Promising Tool against ESKAPE Pathogens |
| title_full_unstemmed | First Evidence of a Combination of Terpinen-4-ol and α-Terpineol as a Promising Tool against ESKAPE Pathogens |
| title_short | First Evidence of a Combination of Terpinen-4-ol and α-Terpineol as a Promising Tool against ESKAPE Pathogens |
| title_sort | first evidence of a combination of terpinen 4 ol and α terpineol as a promising tool against eskape pathogens |
| topic | tea tree oil terpinen-4-ol α-terpineol antibacterial activity synergy cytotoxicity |
| url | https://www.mdpi.com/1420-3049/27/21/7472 |
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