Prolonged ovarian storage of mature Drosophila oocytes dramatically increases meiotic spindle instability

Human oocytes frequently generate aneuploid embryos that subsequently miscarry. In contrast, Drosophila oocytes from outbred laboratory stocks develop fully regardless of maternal age. Since mature Drosophila oocytes are not extensively stored in the ovary under laboratory conditions like they are i...

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Bibliographic Details
Main Authors: Ethan J Greenblatt, Rebecca Obniski, Claire Mical, Allan C Spradling
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/49455

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