Successful Treatment of Gastrosplenic Fistula Arising from Diffuse Large B-Cell Lymphoma with Chemotherapy: Two Case Reports
Gastrosplenic fistula (GSF) is a rare condition arising from gastric or splenic lymphomas. Surgical resection is the most common treatment, as described in previous reports. We report two cases of GSF in diffuse large B-cell lymphoma (DLBCL) patients that were successfully treated with chemotherapy...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2019-05-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/500505 |
| _version_ | 1811270467100606464 |
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| author | Makoto Saito Kencho Miyashita Yosuke Miura Shinpei Harada Reiki Ogasawara Koh Izumiyama Akio Mori Masanori Tanaka Masanobu Morioka Takeshi Kondo |
| author_facet | Makoto Saito Kencho Miyashita Yosuke Miura Shinpei Harada Reiki Ogasawara Koh Izumiyama Akio Mori Masanori Tanaka Masanobu Morioka Takeshi Kondo |
| author_sort | Makoto Saito |
| collection | DOAJ |
| description | Gastrosplenic fistula (GSF) is a rare condition arising from gastric or splenic lymphomas. Surgical resection is the most common treatment, as described in previous reports. We report two cases of GSF in diffuse large B-cell lymphoma (DLBCL) patients that were successfully treated with chemotherapy and irradiation without surgical resection. Case 1 was of a 63-year-old man who had primary gastric DLBCL with a large lesion outside the stomach wall, leading to a spontaneous fistula in the spleen. Case 2 was of a 59-year-old man who had primary splenic DLBCL, which proliferated and infiltrated directly into the stomach. In both cases, chemotherapy comprising rituximab + dose-adjusted EPOCH regimen (etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin) was administered. Case 1 had significant bleeding from the lesion of the stomach during the treatment cycle; however, endoscopic hemostasis was achieved. Case 2 developed a fistula between the stomach and the spleen following therapeutic chemotherapy; however, no complications related to the fistula were observed thereafter. In both cases, irradiation was administered, and complete remission was achieved. |
| first_indexed | 2024-04-12T22:01:17Z |
| format | Article |
| id | doaj.art-ff3a2073a3f34e84adfdc6bf5600cebc |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-04-12T22:01:17Z |
| publishDate | 2019-05-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-ff3a2073a3f34e84adfdc6bf5600cebc2022-12-22T03:15:07ZengKarger PublishersCase Reports in Oncology1662-65752019-05-0112237638310.1159/000500505500505Successful Treatment of Gastrosplenic Fistula Arising from Diffuse Large B-Cell Lymphoma with Chemotherapy: Two Case ReportsMakoto SaitoKencho MiyashitaYosuke MiuraShinpei HaradaReiki OgasawaraKoh IzumiyamaAkio MoriMasanori TanakaMasanobu MoriokaTakeshi KondoGastrosplenic fistula (GSF) is a rare condition arising from gastric or splenic lymphomas. Surgical resection is the most common treatment, as described in previous reports. We report two cases of GSF in diffuse large B-cell lymphoma (DLBCL) patients that were successfully treated with chemotherapy and irradiation without surgical resection. Case 1 was of a 63-year-old man who had primary gastric DLBCL with a large lesion outside the stomach wall, leading to a spontaneous fistula in the spleen. Case 2 was of a 59-year-old man who had primary splenic DLBCL, which proliferated and infiltrated directly into the stomach. In both cases, chemotherapy comprising rituximab + dose-adjusted EPOCH regimen (etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin) was administered. Case 1 had significant bleeding from the lesion of the stomach during the treatment cycle; however, endoscopic hemostasis was achieved. Case 2 developed a fistula between the stomach and the spleen following therapeutic chemotherapy; however, no complications related to the fistula were observed thereafter. In both cases, irradiation was administered, and complete remission was achieved.https://www.karger.com/Article/FullText/500505Gastrosplenic fistula (GSF)Diffuse large B-cell lymphoma (DLBCL)TreatmentChemotherapyIrradiation |
| spellingShingle | Makoto Saito Kencho Miyashita Yosuke Miura Shinpei Harada Reiki Ogasawara Koh Izumiyama Akio Mori Masanori Tanaka Masanobu Morioka Takeshi Kondo Successful Treatment of Gastrosplenic Fistula Arising from Diffuse Large B-Cell Lymphoma with Chemotherapy: Two Case Reports Case Reports in Oncology Gastrosplenic fistula (GSF) Diffuse large B-cell lymphoma (DLBCL) Treatment Chemotherapy Irradiation |
| title | Successful Treatment of Gastrosplenic Fistula Arising from Diffuse Large B-Cell Lymphoma with Chemotherapy: Two Case Reports |
| title_full | Successful Treatment of Gastrosplenic Fistula Arising from Diffuse Large B-Cell Lymphoma with Chemotherapy: Two Case Reports |
| title_fullStr | Successful Treatment of Gastrosplenic Fistula Arising from Diffuse Large B-Cell Lymphoma with Chemotherapy: Two Case Reports |
| title_full_unstemmed | Successful Treatment of Gastrosplenic Fistula Arising from Diffuse Large B-Cell Lymphoma with Chemotherapy: Two Case Reports |
| title_short | Successful Treatment of Gastrosplenic Fistula Arising from Diffuse Large B-Cell Lymphoma with Chemotherapy: Two Case Reports |
| title_sort | successful treatment of gastrosplenic fistula arising from diffuse large b cell lymphoma with chemotherapy two case reports |
| topic | Gastrosplenic fistula (GSF) Diffuse large B-cell lymphoma (DLBCL) Treatment Chemotherapy Irradiation |
| url | https://www.karger.com/Article/FullText/500505 |
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