Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle
To clarify the relationship between beef genetic selection for growth and precocity with muscle metabolism and metabolites, we performed metabolomic analysis using <i>Longissimus lumborum</i> (LL) muscle from Nellore cattle with divergent selection for these traits (high growth, HG; low...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/10/2/58 |
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| author | Nara Regina Brandão Cônsolo Juliana da Silva Vicente Luiz Macedo Buarque Angel Higuera-Padilla Luis Carlos Garibaldi Simon Barbosa Andressa Zawadzki Luis Alberto Colnago Arlindo Saran Netto David Edwin Gerrard Saulo Luz Silva |
| author_facet | Nara Regina Brandão Cônsolo Juliana da Silva Vicente Luiz Macedo Buarque Angel Higuera-Padilla Luis Carlos Garibaldi Simon Barbosa Andressa Zawadzki Luis Alberto Colnago Arlindo Saran Netto David Edwin Gerrard Saulo Luz Silva |
| author_sort | Nara Regina Brandão Cônsolo |
| collection | DOAJ |
| description | To clarify the relationship between beef genetic selection for growth and precocity with muscle metabolism and metabolites, we performed metabolomic analysis using <i>Longissimus lumborum</i> (LL) muscle from Nellore cattle with divergent selection for these traits (high growth, HG; low growth, LG; high precocity, HP; low precocity, LP). Genetic potential for growth affected muscle protein and energetic metabolism. HG animals had a high concentration of arginine, carnosine, and leucine compared to LG animals. HP animals presented a high concentration of glutamine, betaine, creatinine, isoleucine, carnitine, acetyl carnitine, and lower levels of glucose compared to LP animals, affecting protein and fatty acid metabolism. Intensity of selection (high or low) was correlated with changes in protein metabolism, and the type of selection (growth or precocity) affected fat metabolism. In conclusion, both HG and HP appear to be correlated with a high concentration of protein metabolites and changes in protein metabolic pathways, while selection for precocity is more correlated with changes in fat metabolism compared to animals selected for growth. |
| first_indexed | 2024-12-20T01:35:47Z |
| format | Article |
| id | doaj.art-ff3a2d83542a4593b28be8b3140031d9 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-12-20T01:35:47Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-ff3a2d83542a4593b28be8b3140031d92022-12-21T19:58:01ZengMDPI AGMetabolites2218-19892020-02-011025810.3390/metabo10020058metabo10020058Selection for Growth and Precocity Alters Muscle Metabolism in Nellore CattleNara Regina Brandão Cônsolo0Juliana da Silva1Vicente Luiz Macedo Buarque2Angel Higuera-Padilla3Luis Carlos Garibaldi Simon Barbosa4Andressa Zawadzki5Luis Alberto Colnago6Arlindo Saran Netto7David Edwin Gerrard8Saulo Luz Silva9Department of Animal Science, University of São Paulo, Duque de Caxias Norte 225, Pirassununga 13635-900, BrazilDepartment of Animal Science, University of São Paulo, Duque de Caxias Norte 225, Pirassununga 13635-900, BrazilDepartment of Animal Science, University of São Paulo, Duque de Caxias Norte 225, Pirassununga 13635-900, BrazilEMBRAPA Instrumentação, XV de Novembro 1452, São Carlos 13560-970, BrazilEMBRAPA Instrumentação, XV de Novembro 1452, São Carlos 13560-970, BrazilDepartment of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg, DenmarkEMBRAPA Instrumentação, XV de Novembro 1452, São Carlos 13560-970, BrazilDepartment of Animal Science, University of São Paulo, Duque de Caxias Norte 225, Pirassununga 13635-900, BrazilDepartment of Animal and Poultry Sciences, Virginia Tech, Blacksburg, VA 24061, USADepartment of Animal Science, University of São Paulo, Duque de Caxias Norte 225, Pirassununga 13635-900, BrazilTo clarify the relationship between beef genetic selection for growth and precocity with muscle metabolism and metabolites, we performed metabolomic analysis using <i>Longissimus lumborum</i> (LL) muscle from Nellore cattle with divergent selection for these traits (high growth, HG; low growth, LG; high precocity, HP; low precocity, LP). Genetic potential for growth affected muscle protein and energetic metabolism. HG animals had a high concentration of arginine, carnosine, and leucine compared to LG animals. HP animals presented a high concentration of glutamine, betaine, creatinine, isoleucine, carnitine, acetyl carnitine, and lower levels of glucose compared to LP animals, affecting protein and fatty acid metabolism. Intensity of selection (high or low) was correlated with changes in protein metabolism, and the type of selection (growth or precocity) affected fat metabolism. In conclusion, both HG and HP appear to be correlated with a high concentration of protein metabolites and changes in protein metabolic pathways, while selection for precocity is more correlated with changes in fat metabolism compared to animals selected for growth.https://www.mdpi.com/2218-1989/10/2/58genetic selectiongrowthmetabolomicsmuscle metabolitesnmr spectroscopynelloreprecocity |
| spellingShingle | Nara Regina Brandão Cônsolo Juliana da Silva Vicente Luiz Macedo Buarque Angel Higuera-Padilla Luis Carlos Garibaldi Simon Barbosa Andressa Zawadzki Luis Alberto Colnago Arlindo Saran Netto David Edwin Gerrard Saulo Luz Silva Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle Metabolites genetic selection growth metabolomics muscle metabolites nmr spectroscopy nellore precocity |
| title | Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle |
| title_full | Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle |
| title_fullStr | Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle |
| title_full_unstemmed | Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle |
| title_short | Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle |
| title_sort | selection for growth and precocity alters muscle metabolism in nellore cattle |
| topic | genetic selection growth metabolomics muscle metabolites nmr spectroscopy nellore precocity |
| url | https://www.mdpi.com/2218-1989/10/2/58 |
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