Data set on G4 DNA interactions with human proteins
Guanine-rich DNA/RNA fragments can fold into G-quadruplexes (G4s) – non-canonical four-strand secondary structures. The article contains data on quadruplex interaction with human proteins. Binding of three topologically different G4 structures to more than 9000 human proteins was analyzed. Physicoch...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340918302051 |
| _version_ | 1811206767202271232 |
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| author | M. Vlasenok O. Levchenko D. Basmanov D. Klinov A. Varizhuk G. Pozmogova |
| author_facet | M. Vlasenok O. Levchenko D. Basmanov D. Klinov A. Varizhuk G. Pozmogova |
| author_sort | M. Vlasenok |
| collection | DOAJ |
| description | Guanine-rich DNA/RNA fragments can fold into G-quadruplexes (G4s) – non-canonical four-strand secondary structures. The article contains data on quadruplex interaction with human proteins. Binding of three topologically different G4 structures to more than 9000 human proteins was analyzed. Physicochemical methods were used to verify the results.The dataset was generated to identify the protein targets for DNA quadruplex structures for the purpose of better understanding the role of the structures in gene expression regulation. Presented data include functional interpretation of obtained gene lists, visualized with Cytoscape. |
| first_indexed | 2024-04-12T03:53:32Z |
| format | Article |
| id | doaj.art-ff3b25b416624a9b99b75242890f3822 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-04-12T03:53:32Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-ff3b25b416624a9b99b75242890f38222022-12-22T03:48:56ZengElsevierData in Brief2352-34092018-06-0118348359Data set on G4 DNA interactions with human proteinsM. Vlasenok0O. Levchenko1D. Basmanov2D. Klinov3A. Varizhuk4G. Pozmogova5Research and Clinical Center for Physical Chemical Medicine, 119435 Moscow, RussiaResearch and Clinical Center for Physical Chemical Medicine, 119435 Moscow, RussiaResearch and Clinical Center for Physical Chemical Medicine, 119435 Moscow, RussiaResearch and Clinical Center for Physical Chemical Medicine, 119435 Moscow, RussiaResearch and Clinical Center for Physical Chemical Medicine, 119435 Moscow, RussiaCorresponding author.; Research and Clinical Center for Physical Chemical Medicine, 119435 Moscow, RussiaGuanine-rich DNA/RNA fragments can fold into G-quadruplexes (G4s) – non-canonical four-strand secondary structures. The article contains data on quadruplex interaction with human proteins. Binding of three topologically different G4 structures to more than 9000 human proteins was analyzed. Physicochemical methods were used to verify the results.The dataset was generated to identify the protein targets for DNA quadruplex structures for the purpose of better understanding the role of the structures in gene expression regulation. Presented data include functional interpretation of obtained gene lists, visualized with Cytoscape.http://www.sciencedirect.com/science/article/pii/S2352340918302051 |
| spellingShingle | M. Vlasenok O. Levchenko D. Basmanov D. Klinov A. Varizhuk G. Pozmogova Data set on G4 DNA interactions with human proteins Data in Brief |
| title | Data set on G4 DNA interactions with human proteins |
| title_full | Data set on G4 DNA interactions with human proteins |
| title_fullStr | Data set on G4 DNA interactions with human proteins |
| title_full_unstemmed | Data set on G4 DNA interactions with human proteins |
| title_short | Data set on G4 DNA interactions with human proteins |
| title_sort | data set on g4 dna interactions with human proteins |
| url | http://www.sciencedirect.com/science/article/pii/S2352340918302051 |
| work_keys_str_mv | AT mvlasenok datasetong4dnainteractionswithhumanproteins AT olevchenko datasetong4dnainteractionswithhumanproteins AT dbasmanov datasetong4dnainteractionswithhumanproteins AT dklinov datasetong4dnainteractionswithhumanproteins AT avarizhuk datasetong4dnainteractionswithhumanproteins AT gpozmogova datasetong4dnainteractionswithhumanproteins |