Biliary markers of ischemic stroke and gender differences in China
Introduction. Stroke is one of the most important cause of disability and death worldwide. Ischemic stroke patients account for the majority of stroke patients, which takes large burden to patients’ families. This study aimed to explore the association between cholyglycine (CG), total bilirubin (TB...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2023-09-01
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| Series: | Romanian Journal of Neurology |
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| Online Access: | https://rjn.com.ro/articles/2023.3/RJN_2023_3_Art-01.pdf |
| _version_ | 1797354127225782272 |
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| author | Yang Xu Wong Eng Hwa Rusli Bin Nordin Abdul Kareem Meera Mohaideen Benjamin Samraj Prakash Earnest Wong Yin How Le Huahui |
| author_facet | Yang Xu Wong Eng Hwa Rusli Bin Nordin Abdul Kareem Meera Mohaideen Benjamin Samraj Prakash Earnest Wong Yin How Le Huahui |
| author_sort | Yang Xu |
| collection | DOAJ |
| description | Introduction. Stroke is one of the most important cause of disability and death worldwide. Ischemic stroke patients account for the majority of stroke patients, which takes large burden to patients’ families. This study aimed to explore the
association between cholyglycine (CG), total bilirubin (TBIL), indirect bilirubin (IDBIL), direct bilirubin (DBIL) and incidence of ischemic stroke, and to assess detect gender difference. Methods. This was a case-control and retrospective study, all data was collected from medical records in Fuzhou First People’s Hospital in China. Case group consists of 130 ischemic stroke patients at the Department of Neurology in Fuzhou First People’s Hospital. Control group was 130 patients who didn’t have ischemic stroke in the same period and in the
same hospital. In our study, physical examination and clinical history of patients, biochemistry testing indexes of CG, TBIL, DBIL, IDBIL were recorded in medical records. Craniocerebral imaging was examined by magnetic resonance imaging
(MRI) scan and/or computerized tomography (CT). Results. The odds for ischemic stroke increased with CG (adjusted OR=3.028, 95% CI=2.065-4.440, p<0.001), TBIL (adjusted OR=1.110, 95%CI=1.031-1.194, p=0.005), SBP (adjusted OR=1.031, 95%CI=1.015-1.048, p<0.001) and FBS (adjusted OR=1.248, 95%CI=1.069-1.457, p=0.005). There was no gender difference in CG, (adjusted OR=3.898 95%CI=2.244-6.773, P<0.001) in males and (adjusted OR=1.901, 95%CI=1.231-2.935, p=0.004) in females. While there were gender differences in TBIL and DBIL, (adjusted OR=1.086, 95%CI=1.004-1.174, p=0.039), (adjusted OR=1.296, 95%CI=1.025-1.637, p=0.030). Conclusion. CG, TBIL, SBP and FBS were independent predictors of ischemic stroke in China. CG seems more sensitive
than TBIL as the predictor of ischemic stroke. TBIL and DBIL levels had gender difference with the incidence of ischemic stroke and no gender difference in CG levels. |
| first_indexed | 2024-03-08T13:40:50Z |
| format | Article |
| id | doaj.art-ff3cd37c0cc04460b9bf356e84ed9887 |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-03-08T13:40:50Z |
| publishDate | 2023-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-ff3cd37c0cc04460b9bf356e84ed98872024-01-16T10:32:54ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942023-09-0122317718510.37897/RJN.2023.3.1Biliary markers of ischemic stroke and gender differences in ChinaYang Xu0Wong Eng Hwa1Rusli Bin Nordin2Abdul Kareem Meera Mohaideen3Benjamin Samraj Prakash Earnest4Wong Yin How5Le Huahui6School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University (Lakeside Campus), Selangor, Malaysia School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University (Lakeside Campus), Selangor, Malaysia Faculty of Medicine, Bioscience and Nursing, MAHSA University, Selangor, MalaysiaSchool of Medicine, Faculty of Health and Medical Sciences, Taylor’s University (Lakeside Campus), Selangor, MalaysiaSchool of Medicine, Faculty of Health and Medical Sciences, Taylor’s University (Lakeside Campus), Selangor, MalaysiaSchool of Medicine, Faculty of Health and Medical Sciences, Taylor’s University (Lakeside Campus), Selangor, MalaysiaDepartment of Neurology, Fuzhou First People’s Hospital of Jiangxi Province, Fuzhou City, Jiangxi Province, ChinaIntroduction. Stroke is one of the most important cause of disability and death worldwide. Ischemic stroke patients account for the majority of stroke patients, which takes large burden to patients’ families. This study aimed to explore the association between cholyglycine (CG), total bilirubin (TBIL), indirect bilirubin (IDBIL), direct bilirubin (DBIL) and incidence of ischemic stroke, and to assess detect gender difference. Methods. This was a case-control and retrospective study, all data was collected from medical records in Fuzhou First People’s Hospital in China. Case group consists of 130 ischemic stroke patients at the Department of Neurology in Fuzhou First People’s Hospital. Control group was 130 patients who didn’t have ischemic stroke in the same period and in the same hospital. In our study, physical examination and clinical history of patients, biochemistry testing indexes of CG, TBIL, DBIL, IDBIL were recorded in medical records. Craniocerebral imaging was examined by magnetic resonance imaging (MRI) scan and/or computerized tomography (CT). Results. The odds for ischemic stroke increased with CG (adjusted OR=3.028, 95% CI=2.065-4.440, p<0.001), TBIL (adjusted OR=1.110, 95%CI=1.031-1.194, p=0.005), SBP (adjusted OR=1.031, 95%CI=1.015-1.048, p<0.001) and FBS (adjusted OR=1.248, 95%CI=1.069-1.457, p=0.005). There was no gender difference in CG, (adjusted OR=3.898 95%CI=2.244-6.773, P<0.001) in males and (adjusted OR=1.901, 95%CI=1.231-2.935, p=0.004) in females. While there were gender differences in TBIL and DBIL, (adjusted OR=1.086, 95%CI=1.004-1.174, p=0.039), (adjusted OR=1.296, 95%CI=1.025-1.637, p=0.030). Conclusion. CG, TBIL, SBP and FBS were independent predictors of ischemic stroke in China. CG seems more sensitive than TBIL as the predictor of ischemic stroke. TBIL and DBIL levels had gender difference with the incidence of ischemic stroke and no gender difference in CG levels.https://rjn.com.ro/articles/2023.3/RJN_2023_3_Art-01.pdfassociationlevelsincidenceischemic stroke |
| spellingShingle | Yang Xu Wong Eng Hwa Rusli Bin Nordin Abdul Kareem Meera Mohaideen Benjamin Samraj Prakash Earnest Wong Yin How Le Huahui Biliary markers of ischemic stroke and gender differences in China Romanian Journal of Neurology association levels incidence ischemic stroke |
| title | Biliary markers of ischemic stroke and gender differences in China |
| title_full | Biliary markers of ischemic stroke and gender differences in China |
| title_fullStr | Biliary markers of ischemic stroke and gender differences in China |
| title_full_unstemmed | Biliary markers of ischemic stroke and gender differences in China |
| title_short | Biliary markers of ischemic stroke and gender differences in China |
| title_sort | biliary markers of ischemic stroke and gender differences in china |
| topic | association levels incidence ischemic stroke |
| url | https://rjn.com.ro/articles/2023.3/RJN_2023_3_Art-01.pdf |
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