Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells

Expression of α-Smooth Muscle Actin Determines the Fate of Mesenchymal Stromal Cells

Pro-fibrotic microenvironments of scars and tumors characterized by increased stiffness stimulate mesenchymal stromal cells (MSCs) to express α-smooth muscle actin (α-SMA). We investigated whether incorporation of α-SMA into contractile stress fibers regulates human MSC fate. Sorted α-SMA-positive M...

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Bibliographic Details
Main Authors:	Nilesh P. Talele, Julie Fradette, John E. Davies, Andras Kapus, Boris Hinz
Format:	Article
Language:	English
Published:	Elsevier 2015-06-01
Series:	Stem Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671115001332

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