Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies
Abstract Previous studies regarding the zinc status in attention-deficit/hyperactivity disorder (ADHD) yielded inconsistent results. Thus, the present meta-analysis was aimed to estimate the association between hair and serum/plasma zinc levels and ADHD. Online databases of Medline, EMBASE, and Scop...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-94124-5 |
| _version_ | 1818347012467195904 |
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| author | Seyed Mojtaba Ghoreishy Sara Ebrahimi Mousavi Farzaneh Asoudeh Hamed Mohammadi |
| author_facet | Seyed Mojtaba Ghoreishy Sara Ebrahimi Mousavi Farzaneh Asoudeh Hamed Mohammadi |
| author_sort | Seyed Mojtaba Ghoreishy |
| collection | DOAJ |
| description | Abstract Previous studies regarding the zinc status in attention-deficit/hyperactivity disorder (ADHD) yielded inconsistent results. Thus, the present meta-analysis was aimed to estimate the association between hair and serum/plasma zinc levels and ADHD. Online databases of Medline, EMBASE, and Scopus were searched up to October 2020 with no limitation in time and language. Weighted mean differences (WMDs) of hair and serum/plasma zinc levels were calculated using a random-effects model. Overall, 22 articles with 1280 subjects with ADHD and 1200 controls were included. The pooled effect size indicated that serum/plasma zinc levels in subjects with ADHD were not statistically different than their controls (WMD = − 1.26 µmol/L; 95% CI − 3.72, 1.20). Interestingly, the exclusion of one study from the analysis showed that people with ADHD significantly have lower circulating levels of zinc compared to their controls (WMD: − 2.49 µmol/L; 95% CI − 4.29, − 0.69). Also, the pooled effect size indicated that hair zinc levels in cases with ADHD were not statistically different than their controls (WMD = − 24.19 μg/g; 95% CI − 61.80, 13.42). Present meta-analysis raises the possibility that subjects with ADHD are prone to have declined levels of zinc levels. Based on current findings, screening the zinc levels in subjects with ADHD could be reasonable. Further well-designed studies are needed to clarify the role of zinc in the etiology of ADHD. |
| first_indexed | 2024-12-13T17:27:24Z |
| format | Article |
| id | doaj.art-ff409869e4564300a90527ca1439136a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T17:27:24Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ff409869e4564300a90527ca1439136a2022-12-21T23:37:10ZengNature PortfolioScientific Reports2045-23222021-07-0111111010.1038/s41598-021-94124-5Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studiesSeyed Mojtaba Ghoreishy0Sara Ebrahimi Mousavi1Farzaneh Asoudeh2Hamed Mohammadi3Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical SciencesAbstract Previous studies regarding the zinc status in attention-deficit/hyperactivity disorder (ADHD) yielded inconsistent results. Thus, the present meta-analysis was aimed to estimate the association between hair and serum/plasma zinc levels and ADHD. Online databases of Medline, EMBASE, and Scopus were searched up to October 2020 with no limitation in time and language. Weighted mean differences (WMDs) of hair and serum/plasma zinc levels were calculated using a random-effects model. Overall, 22 articles with 1280 subjects with ADHD and 1200 controls were included. The pooled effect size indicated that serum/plasma zinc levels in subjects with ADHD were not statistically different than their controls (WMD = − 1.26 µmol/L; 95% CI − 3.72, 1.20). Interestingly, the exclusion of one study from the analysis showed that people with ADHD significantly have lower circulating levels of zinc compared to their controls (WMD: − 2.49 µmol/L; 95% CI − 4.29, − 0.69). Also, the pooled effect size indicated that hair zinc levels in cases with ADHD were not statistically different than their controls (WMD = − 24.19 μg/g; 95% CI − 61.80, 13.42). Present meta-analysis raises the possibility that subjects with ADHD are prone to have declined levels of zinc levels. Based on current findings, screening the zinc levels in subjects with ADHD could be reasonable. Further well-designed studies are needed to clarify the role of zinc in the etiology of ADHD.https://doi.org/10.1038/s41598-021-94124-5 |
| spellingShingle | Seyed Mojtaba Ghoreishy Sara Ebrahimi Mousavi Farzaneh Asoudeh Hamed Mohammadi Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies Scientific Reports |
| title | Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies |
| title_full | Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies |
| title_fullStr | Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies |
| title_full_unstemmed | Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies |
| title_short | Zinc status in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis of observational studies |
| title_sort | zinc status in attention deficit hyperactivity disorder a systematic review and meta analysis of observational studies |
| url | https://doi.org/10.1038/s41598-021-94124-5 |
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