Live or death in cells: from micronutrition metabolism to cell fate
Micronutrients and cell death have a strong relationship and both are essential for human to maintain good body health. Dysregulation of any micronutrients causes metabolic or chronic diseases, including obesity, cardiometabolic condition, neurodegeneration, and cancer. The nematode Caenorhabditis e...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1185989/full |
| _version_ | 1797828975236481024 |
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| author | Yuting Wang Wei Wu Jianke Gong |
| author_facet | Yuting Wang Wei Wu Jianke Gong |
| author_sort | Yuting Wang |
| collection | DOAJ |
| description | Micronutrients and cell death have a strong relationship and both are essential for human to maintain good body health. Dysregulation of any micronutrients causes metabolic or chronic diseases, including obesity, cardiometabolic condition, neurodegeneration, and cancer. The nematode Caenorhabditis elegans is an ideal genetic organism for researching the mechanisms of micronutrients in metabolism, healthspan, and lifespan. For example, C. elegans is a haem auxotroph, and the research of this special haem trafficking pathway contributes important reference to mammal study. Also, C. elegans characteristics including anatomy simply, clear cell lineage, well-defined genetics, and easily differentiated cell forms make it a powerful tool for studying the mechanisms of cell death including apoptosis, necrosis, autophagy, and ferroptosis. Here, we describe the understanding of micronutrient metabolism currently and also sort out the fundamental mechanisms of different kinds of cell death. A thorough understanding of these physiological processes not only builds a foundation for developing better treatments for various micronutrient disorders but also provides key insights into human health and aging. |
| first_indexed | 2024-04-09T13:13:00Z |
| format | Article |
| id | doaj.art-ff431cc6ecd642bcb8c86dc1321332d9 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-09T13:13:00Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-ff431cc6ecd642bcb8c86dc1321332d92023-05-12T06:24:31ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-05-011110.3389/fcell.2023.11859891185989Live or death in cells: from micronutrition metabolism to cell fateYuting Wang0Wei Wu1Jianke Gong2Key Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaKey Laboratory of Molecular Biophysics of MOE, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaMicronutrients and cell death have a strong relationship and both are essential for human to maintain good body health. Dysregulation of any micronutrients causes metabolic or chronic diseases, including obesity, cardiometabolic condition, neurodegeneration, and cancer. The nematode Caenorhabditis elegans is an ideal genetic organism for researching the mechanisms of micronutrients in metabolism, healthspan, and lifespan. For example, C. elegans is a haem auxotroph, and the research of this special haem trafficking pathway contributes important reference to mammal study. Also, C. elegans characteristics including anatomy simply, clear cell lineage, well-defined genetics, and easily differentiated cell forms make it a powerful tool for studying the mechanisms of cell death including apoptosis, necrosis, autophagy, and ferroptosis. Here, we describe the understanding of micronutrient metabolism currently and also sort out the fundamental mechanisms of different kinds of cell death. A thorough understanding of these physiological processes not only builds a foundation for developing better treatments for various micronutrient disorders but also provides key insights into human health and aging.https://www.frontiersin.org/articles/10.3389/fcell.2023.1185989/fullcell deathnutritionmetabolism disordersignal pathwayCaenorhabditis elegans |
| spellingShingle | Yuting Wang Wei Wu Jianke Gong Live or death in cells: from micronutrition metabolism to cell fate Frontiers in Cell and Developmental Biology cell death nutrition metabolism disorder signal pathway Caenorhabditis elegans |
| title | Live or death in cells: from micronutrition metabolism to cell fate |
| title_full | Live or death in cells: from micronutrition metabolism to cell fate |
| title_fullStr | Live or death in cells: from micronutrition metabolism to cell fate |
| title_full_unstemmed | Live or death in cells: from micronutrition metabolism to cell fate |
| title_short | Live or death in cells: from micronutrition metabolism to cell fate |
| title_sort | live or death in cells from micronutrition metabolism to cell fate |
| topic | cell death nutrition metabolism disorder signal pathway Caenorhabditis elegans |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1185989/full |
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