Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading
Dandan Yao et al. demonstrated that accumulation of formaldehyde in the cerebellum and skeletal muscle contributed toward motor deficits in a mouse model of hindlimb unloading. Their results collectively suggest that scavenging formaldehyde may be a useful treatment to limit motor dysfunction follow...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02448-9 |
| _version_ | 1818994020821499904 |
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| author | Dandan Yao Qingyuan He Shangyin Bai Hang Zhao Jun Yang Dehua Cui Yan Yu Xuechao Fei Yufei Mei Ye Cheng Shi Yan Nayan Huang Yalan Di Xianjie Cai Rui Wang Yajuan Gao Fangrao Cheng Shengjie Zhao Xu Yang Xiang Cai Hongbin Han Jihui Lyu Zhiqian Tong |
| author_facet | Dandan Yao Qingyuan He Shangyin Bai Hang Zhao Jun Yang Dehua Cui Yan Yu Xuechao Fei Yufei Mei Ye Cheng Shi Yan Nayan Huang Yalan Di Xianjie Cai Rui Wang Yajuan Gao Fangrao Cheng Shengjie Zhao Xu Yang Xiang Cai Hongbin Han Jihui Lyu Zhiqian Tong |
| author_sort | Dandan Yao |
| collection | DOAJ |
| description | Dandan Yao et al. demonstrated that accumulation of formaldehyde in the cerebellum and skeletal muscle contributed toward motor deficits in a mouse model of hindlimb unloading. Their results collectively suggest that scavenging formaldehyde may be a useful treatment to limit motor dysfunction following limb offloading conditions. |
| first_indexed | 2024-12-20T20:51:19Z |
| format | Article |
| id | doaj.art-ff43560e61ca4f3fa3079820dd3bb446 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-20T20:51:19Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-ff43560e61ca4f3fa3079820dd3bb4462022-12-21T19:26:55ZengNature PortfolioCommunications Biology2399-36422021-08-014111310.1038/s42003-021-02448-9Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloadingDandan Yao0Qingyuan He1Shangyin Bai2Hang Zhao3Jun Yang4Dehua Cui5Yan Yu6Xuechao Fei7Yufei Mei8Ye Cheng9Shi Yan10Nayan Huang11Yalan Di12Xianjie Cai13Rui Wang14Yajuan Gao15Fangrao Cheng16Shengjie Zhao17Xu Yang18Xiang Cai19Hongbin Han20Jihui Lyu21Zhiqian Tong22Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical UniversityDepartment of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and TechniqueBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical UniversityInstitute of Aging, Key Laboratory of Alzheimer’s Disease of Zhejiang Province, School of Mental Health, Wenzhou Medical UniversityDepartment of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and TechniqueDepartment of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and TechniqueChinese institute of Rehabilitation Science, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and RehabilitationBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical UniversityBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical UniversityBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical UniversityBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical UniversityBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical UniversityBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical UniversityDepartment of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and TechniqueDepartment of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and TechniqueDepartment of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and TechniqueDepartment of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and TechniqueChinese institute of Rehabilitation Science, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and RehabilitationSection of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal UniversityBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical UniversityDepartment of Radiology, Peking University Third Hospital, Beijing, Key Laboratory of Magnetic Resonance Imaging Equipment and TechniqueCenter for Cognitive Disorders, Beijing Geriatric HospitalBeijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical UniversityDandan Yao et al. demonstrated that accumulation of formaldehyde in the cerebellum and skeletal muscle contributed toward motor deficits in a mouse model of hindlimb unloading. Their results collectively suggest that scavenging formaldehyde may be a useful treatment to limit motor dysfunction following limb offloading conditions.https://doi.org/10.1038/s42003-021-02448-9 |
| spellingShingle | Dandan Yao Qingyuan He Shangyin Bai Hang Zhao Jun Yang Dehua Cui Yan Yu Xuechao Fei Yufei Mei Ye Cheng Shi Yan Nayan Huang Yalan Di Xianjie Cai Rui Wang Yajuan Gao Fangrao Cheng Shengjie Zhao Xu Yang Xiang Cai Hongbin Han Jihui Lyu Zhiqian Tong Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading Communications Biology |
| title | Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading |
| title_full | Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading |
| title_fullStr | Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading |
| title_full_unstemmed | Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading |
| title_short | Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading |
| title_sort | accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading |
| url | https://doi.org/10.1038/s42003-021-02448-9 |
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