Optical imaging as a link between cellular neurophysiology and circuit modeling
The relatively simple and highly modular circuitry of the cerebellum raised expectations decades ago that a realistic computational model of cerebellar circuit operations would be feasible, and prove insightful for unraveling cerebellar information processing. To this end, the biophysical properties...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2009-07-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.03.005.2009/full |
| _version_ | 1818159177881616384 |
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| author | Walther Akemann Steven J Middleton Thomas Knopfel |
| author_facet | Walther Akemann Steven J Middleton Thomas Knopfel |
| author_sort | Walther Akemann |
| collection | DOAJ |
| description | The relatively simple and highly modular circuitry of the cerebellum raised expectations decades ago that a realistic computational model of cerebellar circuit operations would be feasible, and prove insightful for unraveling cerebellar information processing. To this end, the biophysical properties of most cerebellar cell types and their synaptic connections have been well characterized and integrated into realistic single cell models. Furthermore, large scale models of cerebellar circuits that extrapolate from single cell properties to circuit dynamics have been constructed. While the development of single cell models have been constrained by microelectrode recordings, guidance and validation as these models are scaled up to study network interactions requires an experimental methodology capable of monitoring cerebellar dynamics at the population level. Here we review the potential of optical imaging techniques to serve this purpose. |
| first_indexed | 2024-12-11T15:41:51Z |
| format | Article |
| id | doaj.art-ff4487cf60d54a2483044b03abf05878 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-11T15:41:51Z |
| publishDate | 2009-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-ff4487cf60d54a2483044b03abf058782022-12-22T00:59:47ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022009-07-01310.3389/neuro.03.005.2009647Optical imaging as a link between cellular neurophysiology and circuit modelingWalther Akemann0Steven J Middleton1Thomas Knopfel2RIKENRIKENRIKENThe relatively simple and highly modular circuitry of the cerebellum raised expectations decades ago that a realistic computational model of cerebellar circuit operations would be feasible, and prove insightful for unraveling cerebellar information processing. To this end, the biophysical properties of most cerebellar cell types and their synaptic connections have been well characterized and integrated into realistic single cell models. Furthermore, large scale models of cerebellar circuits that extrapolate from single cell properties to circuit dynamics have been constructed. While the development of single cell models have been constrained by microelectrode recordings, guidance and validation as these models are scaled up to study network interactions requires an experimental methodology capable of monitoring cerebellar dynamics at the population level. Here we review the potential of optical imaging techniques to serve this purpose.http://journal.frontiersin.org/Journal/10.3389/neuro.03.005.2009/fullCerebellumoptical imagingcalcium probesgenetically encoded probesvoltage probes |
| spellingShingle | Walther Akemann Steven J Middleton Thomas Knopfel Optical imaging as a link between cellular neurophysiology and circuit modeling Frontiers in Cellular Neuroscience Cerebellum optical imaging calcium probes genetically encoded probes voltage probes |
| title | Optical imaging as a link between cellular neurophysiology and circuit modeling |
| title_full | Optical imaging as a link between cellular neurophysiology and circuit modeling |
| title_fullStr | Optical imaging as a link between cellular neurophysiology and circuit modeling |
| title_full_unstemmed | Optical imaging as a link between cellular neurophysiology and circuit modeling |
| title_short | Optical imaging as a link between cellular neurophysiology and circuit modeling |
| title_sort | optical imaging as a link between cellular neurophysiology and circuit modeling |
| topic | Cerebellum optical imaging calcium probes genetically encoded probes voltage probes |
| url | http://journal.frontiersin.org/Journal/10.3389/neuro.03.005.2009/full |
| work_keys_str_mv | AT waltherakemann opticalimagingasalinkbetweencellularneurophysiologyandcircuitmodeling AT stevenjmiddleton opticalimagingasalinkbetweencellularneurophysiologyandcircuitmodeling AT thomasknopfel opticalimagingasalinkbetweencellularneurophysiologyandcircuitmodeling |