Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis
Acid-sensing ion channel 1a (ASIC1a) is a member of the extracellular H+-activated cation channel family. Emerging evidence has suggested that ASIC1a plays a crucial role in the pathogenesis of rheumatoid arthritis (RA). Specifically, ASIC1a could promote inflammation, synovial hyperplasia, articula...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.580936/full |
| _version_ | 1818573763946479616 |
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| author | Yayun Xu Yayun Xu Yayun Xu Feihu Chen Feihu Chen Feihu Chen |
| author_facet | Yayun Xu Yayun Xu Yayun Xu Feihu Chen Feihu Chen Feihu Chen |
| author_sort | Yayun Xu |
| collection | DOAJ |
| description | Acid-sensing ion channel 1a (ASIC1a) is a member of the extracellular H+-activated cation channel family. Emerging evidence has suggested that ASIC1a plays a crucial role in the pathogenesis of rheumatoid arthritis (RA). Specifically, ASIC1a could promote inflammation, synovial hyperplasia, articular cartilage, and bone destruction; these lead to the progression of RA, a chronic autoimmune disease characterized by chronic synovial inflammation and extra-articular lesions. In this review, we provided a brief overview of the molecular properties of ASIC1a, including the basic biological characteristics, tissue and cell distribution, channel blocker, and factors influencing the expression and function, and focused on the potential therapeutic targets of ASIC1a in RA and possible mechanisms of blocking ASIC1a to improve RA symptoms, such as regulation of apoptosis, autophagy, pyroptosis, and necroptosis of articular cartilage, and synovial inflammation and invasion of fibroblast-like cells in synovial tissue. |
| first_indexed | 2024-12-15T00:17:15Z |
| format | Article |
| id | doaj.art-ff44d9ff75fa44939ddd62fb635c4c51 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-15T00:17:15Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ff44d9ff75fa44939ddd62fb635c4c512022-12-21T22:42:26ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-01-011110.3389/fimmu.2020.580936580936Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid ArthritisYayun Xu0Yayun Xu1Yayun Xu2Feihu Chen3Feihu Chen4Feihu Chen5Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaThe Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, ChinaThe Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, ChinaThe Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, ChinaThe Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, ChinaAcid-sensing ion channel 1a (ASIC1a) is a member of the extracellular H+-activated cation channel family. Emerging evidence has suggested that ASIC1a plays a crucial role in the pathogenesis of rheumatoid arthritis (RA). Specifically, ASIC1a could promote inflammation, synovial hyperplasia, articular cartilage, and bone destruction; these lead to the progression of RA, a chronic autoimmune disease characterized by chronic synovial inflammation and extra-articular lesions. In this review, we provided a brief overview of the molecular properties of ASIC1a, including the basic biological characteristics, tissue and cell distribution, channel blocker, and factors influencing the expression and function, and focused on the potential therapeutic targets of ASIC1a in RA and possible mechanisms of blocking ASIC1a to improve RA symptoms, such as regulation of apoptosis, autophagy, pyroptosis, and necroptosis of articular cartilage, and synovial inflammation and invasion of fibroblast-like cells in synovial tissue.https://www.frontiersin.org/articles/10.3389/fimmu.2020.580936/fullacid-sensing ion channel 1arheumatoid arthritisarticular chondrocytesynovial fibroblasttherapeutic target |
| spellingShingle | Yayun Xu Yayun Xu Yayun Xu Feihu Chen Feihu Chen Feihu Chen Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis Frontiers in Immunology acid-sensing ion channel 1a rheumatoid arthritis articular chondrocyte synovial fibroblast therapeutic target |
| title | Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis |
| title_full | Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis |
| title_fullStr | Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis |
| title_full_unstemmed | Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis |
| title_short | Acid-Sensing Ion Channel-1a in Articular Chondrocytes and Synovial Fibroblasts: A Novel Therapeutic Target for Rheumatoid Arthritis |
| title_sort | acid sensing ion channel 1a in articular chondrocytes and synovial fibroblasts a novel therapeutic target for rheumatoid arthritis |
| topic | acid-sensing ion channel 1a rheumatoid arthritis articular chondrocyte synovial fibroblast therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2020.580936/full |
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