Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
The Nemo-like kinase (NLK) plays a regulatory role in immune responses. Here, the authors show that NLK inhibits antiviral IFN responses by phosphorylating the mitochondrial antiviral-signaling protein MAVS and describe a MAVS-derived peptide that exhibits antiviral effects both in vitro and in mice...
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Bibliographic Details
| Main Authors: |
Shang-Ze Li,
Qi-Peng Shu,
Yang Song,
Hui-Hui Zhang,
Yi Liu,
Bing-Xue Jin,
Tian-Zi Liuyu,
Chao Li,
Xi-Chen Huang,
Run-Lei Du,
Wei Song,
Bo Zhong,
Xiao-Dong Zhang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2019-07-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-11258-x
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