Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response
The Nemo-like kinase (NLK) plays a regulatory role in immune responses. Here, the authors show that NLK inhibits antiviral IFN responses by phosphorylating the mitochondrial antiviral-signaling protein MAVS and describe a MAVS-derived peptide that exhibits antiviral effects both in vitro and in mice...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11258-x |
| _version_ | 1818957132360318976 |
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| author | Shang-Ze Li Qi-Peng Shu Yang Song Hui-Hui Zhang Yi Liu Bing-Xue Jin Tian-Zi Liuyu Chao Li Xi-Chen Huang Run-Lei Du Wei Song Bo Zhong Xiao-Dong Zhang |
| author_facet | Shang-Ze Li Qi-Peng Shu Yang Song Hui-Hui Zhang Yi Liu Bing-Xue Jin Tian-Zi Liuyu Chao Li Xi-Chen Huang Run-Lei Du Wei Song Bo Zhong Xiao-Dong Zhang |
| author_sort | Shang-Ze Li |
| collection | DOAJ |
| description | The Nemo-like kinase (NLK) plays a regulatory role in immune responses. Here, the authors show that NLK inhibits antiviral IFN responses by phosphorylating the mitochondrial antiviral-signaling protein MAVS and describe a MAVS-derived peptide that exhibits antiviral effects both in vitro and in mice. |
| first_indexed | 2024-12-20T11:04:59Z |
| format | Article |
| id | doaj.art-ff479f2686d243949b20b20a1875edd4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T11:04:59Z |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ff479f2686d243949b20b20a1875edd42022-12-21T19:42:54ZengNature PortfolioNature Communications2041-17232019-07-0110111410.1038/s41467-019-11258-xPhosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune responseShang-Ze Li0Qi-Peng Shu1Yang Song2Hui-Hui Zhang3Yi Liu4Bing-Xue Jin5Tian-Zi Liuyu6Chao Li7Xi-Chen Huang8Run-Lei Du9Wei Song10Bo Zhong11Xiao-Dong Zhang12Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan UniversityHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan UniversityHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan UniversityCollege of Medicine, Hunan Normal UniversityHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan UniversityHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan UniversityCollege of Life Sciences, Wuhan UniversityHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan UniversityHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan UniversityHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan UniversityDepartment of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Peking Union Medical CollegeCollege of Life Sciences, Wuhan UniversityHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan UniversityThe Nemo-like kinase (NLK) plays a regulatory role in immune responses. Here, the authors show that NLK inhibits antiviral IFN responses by phosphorylating the mitochondrial antiviral-signaling protein MAVS and describe a MAVS-derived peptide that exhibits antiviral effects both in vitro and in mice.https://doi.org/10.1038/s41467-019-11258-x |
| spellingShingle | Shang-Ze Li Qi-Peng Shu Yang Song Hui-Hui Zhang Yi Liu Bing-Xue Jin Tian-Zi Liuyu Chao Li Xi-Chen Huang Run-Lei Du Wei Song Bo Zhong Xiao-Dong Zhang Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response Nature Communications |
| title | Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response |
| title_full | Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response |
| title_fullStr | Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response |
| title_full_unstemmed | Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response |
| title_short | Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response |
| title_sort | phosphorylation of mavs visa by nemo like kinase nlk for degradation regulates the antiviral innate immune response |
| url | https://doi.org/10.1038/s41467-019-11258-x |
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