Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response

Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response

The Nemo-like kinase (NLK) plays a regulatory role in immune responses. Here, the authors show that NLK inhibits antiviral IFN responses by phosphorylating the mitochondrial antiviral-signaling protein MAVS and describe a MAVS-derived peptide that exhibits antiviral effects both in vitro and in mice...

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Bibliographic Details
Main Authors: Shang-Ze Li, Qi-Peng Shu, Yang Song, Hui-Hui Zhang, Yi Liu, Bing-Xue Jin, Tian-Zi Liuyu, Chao Li, Xi-Chen Huang, Run-Lei Du, Wei Song, Bo Zhong, Xiao-Dong Zhang
Format: Article
Language:English
Published: Nature Portfolio 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11258-x

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