Loss, Gain, and Retention: Mechanisms Driving Late Prophase I Chromosome Remodeling for Accurate Meiotic Chromosome Segregation
To generate gametes, sexually reproducing organisms need to achieve a reduction in ploidy, via meiosis. Several mechanisms are set in place to ensure proper reductional chromosome segregation at the first meiotic division (MI), including chromosome remodeling during late prophase I. Chromosome remod...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/3/546 |
| _version_ | 1797471394955526144 |
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| author | Laura I. Láscarez-Lagunas Marina Martinez-Garcia Monica P. Colaiácovo |
| author_facet | Laura I. Láscarez-Lagunas Marina Martinez-Garcia Monica P. Colaiácovo |
| author_sort | Laura I. Láscarez-Lagunas |
| collection | DOAJ |
| description | To generate gametes, sexually reproducing organisms need to achieve a reduction in ploidy, via meiosis. Several mechanisms are set in place to ensure proper reductional chromosome segregation at the first meiotic division (MI), including chromosome remodeling during late prophase I. Chromosome remodeling after crossover formation involves changes in chromosome condensation and restructuring, resulting in a compact bivalent, with sister kinetochores oriented to opposite poles, whose structure is crucial for localized loss of cohesion and accurate chromosome segregation. Here, we review the general processes involved in late prophase I chromosome remodeling, their regulation, and the strategies devised by different organisms to produce bivalents with configurations that promote accurate segregation. |
| first_indexed | 2024-03-09T19:47:52Z |
| format | Article |
| id | doaj.art-ff4805222361435ab847ebcf81552bda |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T19:47:52Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-ff4805222361435ab847ebcf81552bda2023-11-24T01:19:56ZengMDPI AGGenes2073-44252022-03-0113354610.3390/genes13030546Loss, Gain, and Retention: Mechanisms Driving Late Prophase I Chromosome Remodeling for Accurate Meiotic Chromosome SegregationLaura I. Láscarez-Lagunas0Marina Martinez-Garcia1Monica P. Colaiácovo2Department of Genetics, Harvard Medical School, Boston, MA 02115, USADepartment of Biotechnology-Plant Biology, School of Agricultural, Food and Biosystems Engineering, Universidad Politécnica de Madrid, 28040 Madrid, SpainDepartment of Genetics, Harvard Medical School, Boston, MA 02115, USATo generate gametes, sexually reproducing organisms need to achieve a reduction in ploidy, via meiosis. Several mechanisms are set in place to ensure proper reductional chromosome segregation at the first meiotic division (MI), including chromosome remodeling during late prophase I. Chromosome remodeling after crossover formation involves changes in chromosome condensation and restructuring, resulting in a compact bivalent, with sister kinetochores oriented to opposite poles, whose structure is crucial for localized loss of cohesion and accurate chromosome segregation. Here, we review the general processes involved in late prophase I chromosome remodeling, their regulation, and the strategies devised by different organisms to produce bivalents with configurations that promote accurate segregation.https://www.mdpi.com/2073-4425/13/3/546meiosisbivalentchromosome remodelingSC disassemblychromosome segregationsister chromatid cohesion |
| spellingShingle | Laura I. Láscarez-Lagunas Marina Martinez-Garcia Monica P. Colaiácovo Loss, Gain, and Retention: Mechanisms Driving Late Prophase I Chromosome Remodeling for Accurate Meiotic Chromosome Segregation Genes meiosis bivalent chromosome remodeling SC disassembly chromosome segregation sister chromatid cohesion |
| title | Loss, Gain, and Retention: Mechanisms Driving Late Prophase I Chromosome Remodeling for Accurate Meiotic Chromosome Segregation |
| title_full | Loss, Gain, and Retention: Mechanisms Driving Late Prophase I Chromosome Remodeling for Accurate Meiotic Chromosome Segregation |
| title_fullStr | Loss, Gain, and Retention: Mechanisms Driving Late Prophase I Chromosome Remodeling for Accurate Meiotic Chromosome Segregation |
| title_full_unstemmed | Loss, Gain, and Retention: Mechanisms Driving Late Prophase I Chromosome Remodeling for Accurate Meiotic Chromosome Segregation |
| title_short | Loss, Gain, and Retention: Mechanisms Driving Late Prophase I Chromosome Remodeling for Accurate Meiotic Chromosome Segregation |
| title_sort | loss gain and retention mechanisms driving late prophase i chromosome remodeling for accurate meiotic chromosome segregation |
| topic | meiosis bivalent chromosome remodeling SC disassembly chromosome segregation sister chromatid cohesion |
| url | https://www.mdpi.com/2073-4425/13/3/546 |
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