The unpluggable in pursuit of the undruggable: tackling the dark matter of the cancer therapeutics universe

The notion that targeted drugs can unplug gain-of-function tumor pathways has revitalized pharmaceutical research, but the survival benefits of this strategy have so far proven modest. A weakness of oncogene-blocking approaches is that they do not address the problem of cancer progression as selecte...

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Bibliographic Details
Main Author: Richard J. Epstein
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Oncology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00304/full

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