Development of a Novel Sensor Based on Polypyrrole Doped with Potassium Hexacyanoferrate (II) for Detection of L-Tryptophan in Pharmaceutics
This study describes the development of a new sensor with applicability in the determination and quantification of yjr essential amino acid (AA) L-tryptophan (L-TRP) from pharmaceutical products. The proposed sensor is based on a carbon screen-printed electrode (SPCE) modified with the conductor pol...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Inventions |
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| Online Access: | https://www.mdpi.com/2411-5134/6/3/56 |
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| author | Ancuța Dinu Constantin Apetrei |
| author_facet | Ancuța Dinu Constantin Apetrei |
| author_sort | Ancuța Dinu |
| collection | DOAJ |
| description | This study describes the development of a new sensor with applicability in the determination and quantification of yjr essential amino acid (AA) L-tryptophan (L-TRP) from pharmaceutical products. The proposed sensor is based on a carbon screen-printed electrode (SPCE) modified with the conductor polymer polypyrrole (PPy) doped with potassium hexacyanoferrate (II) (FeCN). For the modification of the SPCE with the PPy doped with FeCN, the chronoamperometry (CA) method was used. For the study of the electrochemical behavior and the sensitive properties of the sensor when detecting L-TRP, the cyclic voltammetry (CV) method was used. This developed electrode has shown a high sensibility, a low detection limit (LOD) of up to 1.05 × 10<sup>−7</sup> M, a quantification limit (LOQ) equal to 3.51 × 10<sup>−7</sup> M and a wide linearity range between 3.3 × 10<sup>−7</sup> M and 1.06 × 10<sup>−5</sup> M. The analytical performances of the device were studied for the detection of AA L-TRP from pharmaceutical products, obtaining excellent results. The validation of the electroanalytical method was performed by using the standard method with good results. |
| first_indexed | 2024-03-10T07:34:25Z |
| format | Article |
| id | doaj.art-ff4c926274f64bd8bd749c22f08d629e |
| institution | Directory Open Access Journal |
| issn | 2411-5134 |
| language | English |
| last_indexed | 2024-03-10T07:34:25Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inventions |
| spelling | doaj.art-ff4c926274f64bd8bd749c22f08d629e2023-11-22T13:37:43ZengMDPI AGInventions2411-51342021-07-01635610.3390/inventions6030056Development of a Novel Sensor Based on Polypyrrole Doped with Potassium Hexacyanoferrate (II) for Detection of L-Tryptophan in PharmaceuticsAncuța Dinu0Constantin Apetrei1Department of Chemistry, Phyiscs and Environment, Faculty of Science and Environment, “Dunărea de Jos” University of Galati, 47 Domnească Street, RO-800008 Galati, RomaniaDepartment of Chemistry, Phyiscs and Environment, Faculty of Science and Environment, “Dunărea de Jos” University of Galati, 47 Domnească Street, RO-800008 Galati, RomaniaThis study describes the development of a new sensor with applicability in the determination and quantification of yjr essential amino acid (AA) L-tryptophan (L-TRP) from pharmaceutical products. The proposed sensor is based on a carbon screen-printed electrode (SPCE) modified with the conductor polymer polypyrrole (PPy) doped with potassium hexacyanoferrate (II) (FeCN). For the modification of the SPCE with the PPy doped with FeCN, the chronoamperometry (CA) method was used. For the study of the electrochemical behavior and the sensitive properties of the sensor when detecting L-TRP, the cyclic voltammetry (CV) method was used. This developed electrode has shown a high sensibility, a low detection limit (LOD) of up to 1.05 × 10<sup>−7</sup> M, a quantification limit (LOQ) equal to 3.51 × 10<sup>−7</sup> M and a wide linearity range between 3.3 × 10<sup>−7</sup> M and 1.06 × 10<sup>−5</sup> M. The analytical performances of the device were studied for the detection of AA L-TRP from pharmaceutical products, obtaining excellent results. The validation of the electroanalytical method was performed by using the standard method with good results.https://www.mdpi.com/2411-5134/6/3/56L-tryptophanpolypyrrolesensoramino acidcyclic voltammetrychronoamperometry |
| spellingShingle | Ancuța Dinu Constantin Apetrei Development of a Novel Sensor Based on Polypyrrole Doped with Potassium Hexacyanoferrate (II) for Detection of L-Tryptophan in Pharmaceutics Inventions L-tryptophan polypyrrole sensor amino acid cyclic voltammetry chronoamperometry |
| title | Development of a Novel Sensor Based on Polypyrrole Doped with Potassium Hexacyanoferrate (II) for Detection of L-Tryptophan in Pharmaceutics |
| title_full | Development of a Novel Sensor Based on Polypyrrole Doped with Potassium Hexacyanoferrate (II) for Detection of L-Tryptophan in Pharmaceutics |
| title_fullStr | Development of a Novel Sensor Based on Polypyrrole Doped with Potassium Hexacyanoferrate (II) for Detection of L-Tryptophan in Pharmaceutics |
| title_full_unstemmed | Development of a Novel Sensor Based on Polypyrrole Doped with Potassium Hexacyanoferrate (II) for Detection of L-Tryptophan in Pharmaceutics |
| title_short | Development of a Novel Sensor Based on Polypyrrole Doped with Potassium Hexacyanoferrate (II) for Detection of L-Tryptophan in Pharmaceutics |
| title_sort | development of a novel sensor based on polypyrrole doped with potassium hexacyanoferrate ii for detection of l tryptophan in pharmaceutics |
| topic | L-tryptophan polypyrrole sensor amino acid cyclic voltammetry chronoamperometry |
| url | https://www.mdpi.com/2411-5134/6/3/56 |
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