A huge intracardiac thrombus developed in the presence of antithrombin III deficiency in a patient with end-stage renal failure

In this study, we report a 15-year-old female with end-stage renal disease undergoing hemodialysis, who admitted with acute respiratory failure and generalized edema. Abdominal tomography detected thrombi in the right renal vein, in the hepatic segment of the inferior vena cava and in iliac veins. L...

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Main Authors: Fatih Köksal Binnetoğlu, Kadir Babaoğlu, Nazan Sarper, Kenan Bek
Format: Article
Language:English
Published: KARE Publishing 2013-10-01
Series:Türk Kardiyoloji Derneği Arşivi
Subjects:
Online Access:https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-88288
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author Fatih Köksal Binnetoğlu
Kadir Babaoğlu
Nazan Sarper
Kenan Bek
author_facet Fatih Köksal Binnetoğlu
Kadir Babaoğlu
Nazan Sarper
Kenan Bek
author_sort Fatih Köksal Binnetoğlu
collection DOAJ
description In this study, we report a 15-year-old female with end-stage renal disease undergoing hemodialysis, who admitted with acute respiratory failure and generalized edema. Abdominal tomography detected thrombi in the right renal vein, in the hepatic segment of the inferior vena cava and in iliac veins. Levels of proteins C and S, antinuclear antigen, anti-dsDNA, C3, and C4 were in normal limits. The thrombi persisted despite treatment with nadroparin, heparin with fresh frozen plasma and warfarin. Due to heparin resistance, antithrombin III levels were measured and were found abnormally low. The first echocardiographic examination was in normal limits but the second echocardiography revealed a huge thrombus occluding the tricuspid valve. Urgent thrombectomy was planned but the patient died in the intensive care unit due to severe pulmonary edema.
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spelling doaj.art-ff4d689c5d9d4553b457ff49517769342023-02-15T16:19:28ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692013-10-0141764264510.5543/tkda.2013.88288TKDA-88288A huge intracardiac thrombus developed in the presence of antithrombin III deficiency in a patient with end-stage renal failureFatih Köksal Binnetoğlu0Kadir Babaoğlu1Nazan Sarper2Kenan Bek3Department of Pediatric Cardiology, Kocaeli University Faculty of Medicine, IzmitDepartment of Pediatric Cardiology, Kocaeli University Faculty of Medicine, IzmitDepartment of Pediatric Hematology, Kocaeli University Faculty of Medicine, IzmitDepartment of Pediatric Nephrology, Kocaeli University Faculty of Medicine, IzmitIn this study, we report a 15-year-old female with end-stage renal disease undergoing hemodialysis, who admitted with acute respiratory failure and generalized edema. Abdominal tomography detected thrombi in the right renal vein, in the hepatic segment of the inferior vena cava and in iliac veins. Levels of proteins C and S, antinuclear antigen, anti-dsDNA, C3, and C4 were in normal limits. The thrombi persisted despite treatment with nadroparin, heparin with fresh frozen plasma and warfarin. Due to heparin resistance, antithrombin III levels were measured and were found abnormally low. The first echocardiographic examination was in normal limits but the second echocardiography revealed a huge thrombus occluding the tricuspid valve. Urgent thrombectomy was planned but the patient died in the intensive care unit due to severe pulmonary edema.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-88288antithrombin iiicardiovascular diseases/etiologykidney failurechronic/physiopathology/complications; renal dialysis; thrombosis.
spellingShingle Fatih Köksal Binnetoğlu
Kadir Babaoğlu
Nazan Sarper
Kenan Bek
A huge intracardiac thrombus developed in the presence of antithrombin III deficiency in a patient with end-stage renal failure
Türk Kardiyoloji Derneği Arşivi
antithrombin iii
cardiovascular diseases/etiology
kidney failure
chronic/physiopathology/complications; renal dialysis; thrombosis.
title A huge intracardiac thrombus developed in the presence of antithrombin III deficiency in a patient with end-stage renal failure
title_full A huge intracardiac thrombus developed in the presence of antithrombin III deficiency in a patient with end-stage renal failure
title_fullStr A huge intracardiac thrombus developed in the presence of antithrombin III deficiency in a patient with end-stage renal failure
title_full_unstemmed A huge intracardiac thrombus developed in the presence of antithrombin III deficiency in a patient with end-stage renal failure
title_short A huge intracardiac thrombus developed in the presence of antithrombin III deficiency in a patient with end-stage renal failure
title_sort huge intracardiac thrombus developed in the presence of antithrombin iii deficiency in a patient with end stage renal failure
topic antithrombin iii
cardiovascular diseases/etiology
kidney failure
chronic/physiopathology/complications; renal dialysis; thrombosis.
url https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-88288
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