Emerging targets in human lymphoma: targeting the MYD88 mutation
James Q Wang,* Yogesh S Jeelall,* Keisuke Horikawa* Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia *All authors contributed equally to this manuscript Abstract: B cell neoplasms co-opt the molecular machinery of normal B...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2013-08-01
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| Series: | Blood and Lymphatic Cancer: Targets and Therapy |
| Online Access: | http://www.dovepress.com/emerging-targets-in-human-lymphoma-targeting-the-myd88-mutation-a14017 |
| _version_ | 1818926732258836480 |
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| author | Wang JQ Jeelall YS Horikawa K |
| author_facet | Wang JQ Jeelall YS Horikawa K |
| author_sort | Wang JQ |
| collection | DOAJ |
| description | James Q Wang,* Yogesh S Jeelall,* Keisuke Horikawa* Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia *All authors contributed equally to this manuscript Abstract: B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link between TLR signaling and B cell neoplasm. Recurrent oncogenic mutations in MYD88 have been found in 39% of the activated B cell-like subtype of diffuse large B cell lymphoma (ABC DLBCL). Interestingly, 29% of ABC DLBCL have a single amino acid substitution of proline for the leucine at position 265 (L265P), and the exact same variant has also been identified in a number of lymphoid malignancies. The MYD88 L265P variant was recently identified in 90% of Wadenstrom's macroglobulinemia patients. These recent developments warrant the need for novel diagnostic tools as well as targeted therapeutics. In this review, we discuss the physiological functions of MYD88 and focus on its role in B cell lymphomas, evaluating the potential for targeting oncogenic MYD88 in lymphoma. Keywords: MYD88, L265P mutation, lymphoma, targeted therapy |
| first_indexed | 2024-12-20T03:01:47Z |
| format | Article |
| id | doaj.art-ff4e0887c6a4423ab1ae6b7efdc73c1c |
| institution | Directory Open Access Journal |
| issn | 1179-9889 |
| language | English |
| last_indexed | 2024-12-20T03:01:47Z |
| publishDate | 2013-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Blood and Lymphatic Cancer: Targets and Therapy |
| spelling | doaj.art-ff4e0887c6a4423ab1ae6b7efdc73c1c2022-12-21T19:55:44ZengDove Medical PressBlood and Lymphatic Cancer: Targets and Therapy1179-98892013-08-012013default5361Emerging targets in human lymphoma: targeting the MYD88 mutationWang JQJeelall YSHorikawa KJames Q Wang,* Yogesh S Jeelall,* Keisuke Horikawa* Department of Immunology, The John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia *All authors contributed equally to this manuscript Abstract: B cell neoplasms co-opt the molecular machinery of normal B cells for their survival. Technological advances in cancer genomics has significantly contributed to uncovering the root cause of aggressive lymphomas, revealing a previously unknown link between TLR signaling and B cell neoplasm. Recurrent oncogenic mutations in MYD88 have been found in 39% of the activated B cell-like subtype of diffuse large B cell lymphoma (ABC DLBCL). Interestingly, 29% of ABC DLBCL have a single amino acid substitution of proline for the leucine at position 265 (L265P), and the exact same variant has also been identified in a number of lymphoid malignancies. The MYD88 L265P variant was recently identified in 90% of Wadenstrom's macroglobulinemia patients. These recent developments warrant the need for novel diagnostic tools as well as targeted therapeutics. In this review, we discuss the physiological functions of MYD88 and focus on its role in B cell lymphomas, evaluating the potential for targeting oncogenic MYD88 in lymphoma. Keywords: MYD88, L265P mutation, lymphoma, targeted therapyhttp://www.dovepress.com/emerging-targets-in-human-lymphoma-targeting-the-myd88-mutation-a14017 |
| spellingShingle | Wang JQ Jeelall YS Horikawa K Emerging targets in human lymphoma: targeting the MYD88 mutation Blood and Lymphatic Cancer: Targets and Therapy |
| title | Emerging targets in human lymphoma: targeting the MYD88 mutation |
| title_full | Emerging targets in human lymphoma: targeting the MYD88 mutation |
| title_fullStr | Emerging targets in human lymphoma: targeting the MYD88 mutation |
| title_full_unstemmed | Emerging targets in human lymphoma: targeting the MYD88 mutation |
| title_short | Emerging targets in human lymphoma: targeting the MYD88 mutation |
| title_sort | emerging targets in human lymphoma targeting the myd88 mutation |
| url | http://www.dovepress.com/emerging-targets-in-human-lymphoma-targeting-the-myd88-mutation-a14017 |
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