Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study
The use of UCH-L1 detection with point-of-care (POC) assay alone has not been characterized for clinical use. This study compares the accuracies of POC UCH-L1 and Neuron-Specific Enolase (NSE) Elecsys® levels for identifying TBI patients with structural abnormalities on neuroimaging.The Transforming...
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co. Ltd.
2023-01-01
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| Series: | Advances in Biomarker Sciences and Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2543106423000042 |
| _version_ | 1827338889554034688 |
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| author | Kevin K. Wang Jennifer C. Munoz-Pareja Lauren A. Lautenslager J. Adrian Tyndall Zhihui Yang Maria R. Kerrigan Ramon Diaz-Arrastia Frederick K. Korley David Okonkwo Ava M. Puccio John K. Yue Sabrina R. Taylor Pratik Mukherjee Esther L. Yuh Nancy R. Temkin Claudia S. Robertson Xiaoying Sun Sonia Jain Amy J. Markowitz Geoffrey T. Manley Opeolu Adeoye Neeraj Badjatia Kim Boase Yelena Bodien M. Ross Bullock Randall Chesnut John D. Corrigan Karen Crawford Sureyya Dikmen Ann-Christine Duhaime Richard Ellenbogen V Ramana Feeser Adam R. Ferguson Brandon Foreman Raquel Gardner Etienne Gaudette Joseph Giacino Luis Gonzalez Shankar Gopinath Rao Gullapalli J Claude Hemphill Gillian Hotz Joel Kramer Natalie Kreitzer Harvey Levin Chris Lindsell Joan Machamer Christopher Madden Alastair Martin Thomas McAllister Michael McCrea Randall Merchant Lindsay Nelson Laura Ngwenya Eva Palacios Daniel Perl Miri Rabinowitz Jonathan Rosand Angelle Sander Gabriella Satris David Schnyer Seth Seabury Arthur Toga Alex Valadka Mary Vassar Paul Vespa Ross Zafonte |
| author_facet | Kevin K. Wang Jennifer C. Munoz-Pareja Lauren A. Lautenslager J. Adrian Tyndall Zhihui Yang Maria R. Kerrigan Ramon Diaz-Arrastia Frederick K. Korley David Okonkwo Ava M. Puccio John K. Yue Sabrina R. Taylor Pratik Mukherjee Esther L. Yuh Nancy R. Temkin Claudia S. Robertson Xiaoying Sun Sonia Jain Amy J. Markowitz Geoffrey T. Manley Opeolu Adeoye Neeraj Badjatia Kim Boase Yelena Bodien M. Ross Bullock Randall Chesnut John D. Corrigan Karen Crawford Sureyya Dikmen Ann-Christine Duhaime Richard Ellenbogen V Ramana Feeser Adam R. Ferguson Brandon Foreman Raquel Gardner Etienne Gaudette Joseph Giacino Luis Gonzalez Shankar Gopinath Rao Gullapalli J Claude Hemphill Gillian Hotz Joel Kramer Natalie Kreitzer Harvey Levin Chris Lindsell Joan Machamer Christopher Madden Alastair Martin Thomas McAllister Michael McCrea Randall Merchant Lindsay Nelson Laura Ngwenya Eva Palacios Daniel Perl Miri Rabinowitz Jonathan Rosand Angelle Sander Gabriella Satris David Schnyer Seth Seabury Arthur Toga Alex Valadka Mary Vassar Paul Vespa Ross Zafonte |
| author_sort | Kevin K. Wang |
| collection | DOAJ |
| description | The use of UCH-L1 detection with point-of-care (POC) assay alone has not been characterized for clinical use. This study compares the accuracies of POC UCH-L1 and Neuron-Specific Enolase (NSE) Elecsys® levels for identifying TBI patients with structural abnormalities on neuroimaging.The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Phase 1 Cohort, enrolled 1375 TBI patients (GCS 3–15) presenting to one of 18 US Level I trauma centers within 24 h of injury who had an admission head CT; blood samples were collected, along with 122 orthopedic and 209 healthy controls. The TBI cohort consisted of 810 CT-negative (CT-) and 549 CT-positive (CT+) subjects. Of the CT- subjects who had MRIs, 121 were MRI-positive (MRI+) and 333 were MRI-negative (MRI-). UCH-L1 POC showed best diagnostic performance for CT + versus CT-, 0–8 h post-injury with an AUC of 0·779 [0·708–0.850] when compared to the 0–25 h interval, with an AUC of 0.684 [0.655–0.712]. NSE assay has an AUC of 0.695 [0.619–0.770] for the 0–8 h interval and 0.634 [0.603–0.665] for the 0–25 h interval. During the first 8 after injury, POC UCH-L1 outperforms NSE in identifying TBI patients with structural abnormalities on neuroimaging. |
| first_indexed | 2024-03-07T19:42:07Z |
| format | Article |
| id | doaj.art-ff4e137c9e3f4549b236e15d7afcfe6d |
| institution | Directory Open Access Journal |
| issn | 2543-1064 |
| language | English |
| last_indexed | 2024-03-07T19:42:07Z |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Advances in Biomarker Sciences and Technology |
| spelling | doaj.art-ff4e137c9e3f4549b236e15d7afcfe6d2024-02-29T05:20:12ZengKeAi Communications Co. Ltd.Advances in Biomarker Sciences and Technology2543-10642023-01-0153849Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort studyKevin K. Wang0Jennifer C. Munoz-Pareja1Lauren A. Lautenslager2J. Adrian Tyndall3Zhihui Yang4Maria R. Kerrigan5Ramon Diaz-Arrastia6Frederick K. Korley7David Okonkwo8Ava M. Puccio9John K. Yue10Sabrina R. Taylor11Pratik Mukherjee12Esther L. Yuh13Nancy R. Temkin14Claudia S. Robertson15Xiaoying Sun16Sonia Jain17Amy J. Markowitz18Geoffrey T. Manley19Opeolu Adeoye20Neeraj Badjatia21Kim Boase22Yelena Bodien23M. Ross Bullock24Randall Chesnut25John D. Corrigan26Karen Crawford27Sureyya Dikmen28Ann-Christine Duhaime29Richard Ellenbogen30V Ramana Feeser31Adam R. Ferguson32Brandon Foreman33Raquel Gardner34Etienne Gaudette35Joseph Giacino36Luis Gonzalez37Shankar Gopinath38Rao Gullapalli39J Claude Hemphill40Gillian Hotz41Joel Kramer42Natalie Kreitzer43Harvey Levin44Chris Lindsell45Joan Machamer46Christopher Madden47Alastair Martin48Thomas McAllister49Michael McCrea50Randall Merchant51Lindsay Nelson52Laura Ngwenya53Eva Palacios54Daniel Perl55Miri Rabinowitz56Jonathan Rosand57Angelle Sander58Gabriella Satris59David Schnyer60Seth Seabury61Arthur Toga62Alex Valadka63Mary Vassar64Paul Vespa65Ross Zafonte66Department of Neurobiology, Center for Neurotrauma, Multiomics & Biomarkers (CNMB), Morehouse School of Medicine Atlanta, GA, USADepartment of Pediatric Critical Care, University of Miami Miller School of Medicine, Miami, FL, USA; Corresponding author.University of Florida College of Medicine, Gainesville, FL, USADepartment of Emergency Medicine, Morehouse School of Medicine, Atlanta, GA, USADepartment of Neurobiology, Center for Neurotrauma, Multiomics & Biomarkers (CNMB), Morehouse School of Medicine Atlanta, GA, USAUniversity of Florida College of Medicine, Gainesville, FL, USADepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USAUniversity of Michigan, Department of Emergency Medicine, Ann Arbor, MI, USADepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USADepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USADepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USADepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USADepartment of Radiology University of California San Francisco, San Francisco, CA, USADepartment of Radiology University of California San Francisco, San Francisco, CA, USADepartment of Biostatistics and Neurological Surgery, University of Washington, Seattle, WA, USAThe Center for Neurosurgical Intensive Care, Ben Taub General Hospital, Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USADepartment of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USADepartment of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USADepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USADepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USAUniversity of Cincinnati, USAUniversity of Maryland, USAUniversity of Washington, USAMassachusetts General Hospital, USAUniversity of Miami, USAUniversity of Washington, USAABPP, Ohio State University, USAUniversity of Southern California, USAUniversity of Washington, USAMass General Hospital, USAUniversity of Washington, USAVirginia Commonwealth University, USAUniversity of California, San Francisco, USAUniversity of Cincinnati, USAUniversity of California, San Francisco, USAUniversity of Southern California, USASpaulding Rehabilitation Hospital, USATIRR Memorial Hermann, USABaylor College of Medicine, USAUniversity of Maryland, USAUniversity of California, San Francisco, USAUniversity of Miami, USAUniversity of California, San Francisco, USAUniversity of Cincinnati, USABaylor College of Medicine, USAVanderbilt University, USAUniversity of Washington, USAUT Southwestern, USAUniversity of California, San Francisco, USAIndiana University, USAMedical College of Wisconsin, USAVirginia Commonwealth University, USAMedical College of Wisconsin, USAUniversity of Cincinnatti, USAUniversity of California, San Francisco, USAUniformed Services University, USAUniversity of Pittsburgh, USAMassachusetts General Hospital, USABaylor College of Medicine, USAUniversity of California, San Francisco, USAUT Austin, USAUniversity of Southern California, USAUniversity of Southern California, USAVirginia Commonwealth University, USAUniversity of California, San Francisco, USAUniversity of California, Los Angeles, USAHarvard Medical School, USAThe use of UCH-L1 detection with point-of-care (POC) assay alone has not been characterized for clinical use. This study compares the accuracies of POC UCH-L1 and Neuron-Specific Enolase (NSE) Elecsys® levels for identifying TBI patients with structural abnormalities on neuroimaging.The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Phase 1 Cohort, enrolled 1375 TBI patients (GCS 3–15) presenting to one of 18 US Level I trauma centers within 24 h of injury who had an admission head CT; blood samples were collected, along with 122 orthopedic and 209 healthy controls. The TBI cohort consisted of 810 CT-negative (CT-) and 549 CT-positive (CT+) subjects. Of the CT- subjects who had MRIs, 121 were MRI-positive (MRI+) and 333 were MRI-negative (MRI-). UCH-L1 POC showed best diagnostic performance for CT + versus CT-, 0–8 h post-injury with an AUC of 0·779 [0·708–0.850] when compared to the 0–25 h interval, with an AUC of 0.684 [0.655–0.712]. NSE assay has an AUC of 0.695 [0.619–0.770] for the 0–8 h interval and 0.634 [0.603–0.665] for the 0–25 h interval. During the first 8 after injury, POC UCH-L1 outperforms NSE in identifying TBI patients with structural abnormalities on neuroimaging.http://www.sciencedirect.com/science/article/pii/S2543106423000042TBIBiomarkersUCH-L1Point of careMild TBINSE |
| spellingShingle | Kevin K. Wang Jennifer C. Munoz-Pareja Lauren A. Lautenslager J. Adrian Tyndall Zhihui Yang Maria R. Kerrigan Ramon Diaz-Arrastia Frederick K. Korley David Okonkwo Ava M. Puccio John K. Yue Sabrina R. Taylor Pratik Mukherjee Esther L. Yuh Nancy R. Temkin Claudia S. Robertson Xiaoying Sun Sonia Jain Amy J. Markowitz Geoffrey T. Manley Opeolu Adeoye Neeraj Badjatia Kim Boase Yelena Bodien M. Ross Bullock Randall Chesnut John D. Corrigan Karen Crawford Sureyya Dikmen Ann-Christine Duhaime Richard Ellenbogen V Ramana Feeser Adam R. Ferguson Brandon Foreman Raquel Gardner Etienne Gaudette Joseph Giacino Luis Gonzalez Shankar Gopinath Rao Gullapalli J Claude Hemphill Gillian Hotz Joel Kramer Natalie Kreitzer Harvey Levin Chris Lindsell Joan Machamer Christopher Madden Alastair Martin Thomas McAllister Michael McCrea Randall Merchant Lindsay Nelson Laura Ngwenya Eva Palacios Daniel Perl Miri Rabinowitz Jonathan Rosand Angelle Sander Gabriella Satris David Schnyer Seth Seabury Arthur Toga Alex Valadka Mary Vassar Paul Vespa Ross Zafonte Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study Advances in Biomarker Sciences and Technology TBI Biomarkers UCH-L1 Point of care Mild TBI NSE |
| title | Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study |
| title_full | Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study |
| title_fullStr | Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study |
| title_full_unstemmed | Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study |
| title_short | Diagnostic performance of point-of-care ubiquitin carboxy-terminal Hydrolase-L1 assay in distinguishing imaging abnormalities in traumatic brain injury: A TRACK-TBI cohort study |
| title_sort | diagnostic performance of point of care ubiquitin carboxy terminal hydrolase l1 assay in distinguishing imaging abnormalities in traumatic brain injury a track tbi cohort study |
| topic | TBI Biomarkers UCH-L1 Point of care Mild TBI NSE |
| url | http://www.sciencedirect.com/science/article/pii/S2543106423000042 |
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