Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome
Background The Human Respiratory Tract (HRT) is colonized by various microbial taxa, known as HRT microbiota, in a manner that is indicative of mutualistic interaction between such microorganisms and their host.Aim To investigate the microbial composition of the HRT and its possible correlation with...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Journal of Oral Microbiology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2022.2051336 |
| _version_ | 1811257722906083328 |
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| author | Leonardo Mancabelli Christian Milani Federico Fontana Gabriele Andrea Lugli Chiara Tarracchini Francesca Turroni Douwe van Sinderen Marco Ventura |
| author_facet | Leonardo Mancabelli Christian Milani Federico Fontana Gabriele Andrea Lugli Chiara Tarracchini Francesca Turroni Douwe van Sinderen Marco Ventura |
| author_sort | Leonardo Mancabelli |
| collection | DOAJ |
| description | Background The Human Respiratory Tract (HRT) is colonized by various microbial taxa, known as HRT microbiota, in a manner that is indicative of mutualistic interaction between such microorganisms and their host.Aim To investigate the microbial composition of the HRT and its possible correlation with the different compartments of the respiratory tract.Methods In the current study, we performed an in-depth meta‐analysis of 849 HRT samples from public shotgun metagenomic datasets obtained through several distinct collection methods.Results The statistical robustness provided by this meta-analysis allowed the identification of 13 possible HRT-specific Community State Types (CSTs), which appear to be specific to each anatomical region of the respiratory tract. Furthermore, functional characterization of the metagenomic datasets revealed specific microbial metabolic features correlating with the different compartments of the respiratory tract.Conclusion The meta-analysis here performed suggested that the variable presence of certain bacterial species seems to be linked to a location-related abundance gradient in the HRT and seems to be characterized by a specific microbial metabolic capability. |
| first_indexed | 2024-04-12T18:01:54Z |
| format | Article |
| id | doaj.art-ff50409bd2984742a1856ef527170350 |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-04-12T18:01:54Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-ff50409bd2984742a1856ef5271703502022-12-22T03:22:09ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972022-12-0114110.1080/20002297.2022.2051336Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiomeLeonardo Mancabelli0Christian Milani1Federico Fontana2Gabriele Andrea Lugli3Chiara Tarracchini4Francesca Turroni5Douwe van Sinderen6Marco Ventura7Laboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, ItalyLaboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, ItalyLaboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, ItalyLaboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, ItalyLaboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, ItalyLaboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, ItalyAPC Microbiome Institute and School of Microbiology, Bioscience Institute, National University of Ireland, Cork, IrelandLaboratory of Probiogenomics, Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parma, ItalyBackground The Human Respiratory Tract (HRT) is colonized by various microbial taxa, known as HRT microbiota, in a manner that is indicative of mutualistic interaction between such microorganisms and their host.Aim To investigate the microbial composition of the HRT and its possible correlation with the different compartments of the respiratory tract.Methods In the current study, we performed an in-depth meta‐analysis of 849 HRT samples from public shotgun metagenomic datasets obtained through several distinct collection methods.Results The statistical robustness provided by this meta-analysis allowed the identification of 13 possible HRT-specific Community State Types (CSTs), which appear to be specific to each anatomical region of the respiratory tract. Furthermore, functional characterization of the metagenomic datasets revealed specific microbial metabolic features correlating with the different compartments of the respiratory tract.Conclusion The meta-analysis here performed suggested that the variable presence of certain bacterial species seems to be linked to a location-related abundance gradient in the HRT and seems to be characterized by a specific microbial metabolic capability.https://www.tandfonline.com/doi/10.1080/20002297.2022.2051336Human respiratory tractoral microbiotapulmonarymicrobiomeshotgun metagenomicssputum |
| spellingShingle | Leonardo Mancabelli Christian Milani Federico Fontana Gabriele Andrea Lugli Chiara Tarracchini Francesca Turroni Douwe van Sinderen Marco Ventura Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome Journal of Oral Microbiology Human respiratory tract oral microbiota pulmonary microbiome shotgun metagenomics sputum |
| title | Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome |
| title_full | Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome |
| title_fullStr | Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome |
| title_full_unstemmed | Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome |
| title_short | Mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome |
| title_sort | mapping bacterial diversity and metabolic functionality of the human respiratory tract microbiome |
| topic | Human respiratory tract oral microbiota pulmonary microbiome shotgun metagenomics sputum |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2022.2051336 |
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