Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of <i>Lactobacillus casei</i> and <i>Lactobacillus acidophilus</i>
Rheumatoid arthritis is a chronic autoimmune disorder that can lead to disability conditions with swollen joints, pain, stiffness, cartilage degradation, and osteoporosis. Genetic, epigenetic, sex-specific factors, smoking, air pollution, food, oral hygiene, periodontitis, <i>Prevotella</i&...
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| Format: | Article |
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MDPI AG
2021-05-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/5/1070 |
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| author | Alok K. Paul Anita Paul Rownak Jahan Khoshnur Jannat Tohmina A. Bondhon Anamul Hasan Veeranoot Nissapatorn Maria L. Pereira Polrat Wilairatana Mohammed Rahmatullah |
| author_facet | Alok K. Paul Anita Paul Rownak Jahan Khoshnur Jannat Tohmina A. Bondhon Anamul Hasan Veeranoot Nissapatorn Maria L. Pereira Polrat Wilairatana Mohammed Rahmatullah |
| author_sort | Alok K. Paul |
| collection | DOAJ |
| description | Rheumatoid arthritis is a chronic autoimmune disorder that can lead to disability conditions with swollen joints, pain, stiffness, cartilage degradation, and osteoporosis. Genetic, epigenetic, sex-specific factors, smoking, air pollution, food, oral hygiene, periodontitis, <i>Prevotella</i>, and imbalance in the gastrointestinal microbiota are possible sources of the initiation or progression of rheumatoid arthritis, although the detailed mechanisms still need to be elucidated. Probiotics containing <i>Lactobacillus spp.</i> are commonly used as alleviating agents or food supplements to manage diarrhea, dysentery, develop immunity, and maintain general health. The mechanism of action of <i>Lactobacillus spp.</i> against rheumatoid arthritis is still not clearly known to date. In this narrative review, we recapitulate the findings of recent studies to understand the overall pathogenesis of rheumatoid arthritis and the roles of <i>probiotics,</i> particularly <i>L. casei</i> or <i>L. acidophilus,</i> in the management of rheumatoid arthritis in clinical and preclinical studies. |
| first_indexed | 2024-03-10T11:22:32Z |
| format | Article |
| id | doaj.art-ff51318e6e0d4150bad2a667bb3cb742 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T11:22:32Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-ff51318e6e0d4150bad2a667bb3cb7422023-11-21T19:56:37ZengMDPI AGMicroorganisms2076-26072021-05-0195107010.3390/microorganisms9051070Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of <i>Lactobacillus casei</i> and <i>Lactobacillus acidophilus</i>Alok K. Paul0Anita Paul1Rownak Jahan2Khoshnur Jannat3Tohmina A. Bondhon4Anamul Hasan5Veeranoot Nissapatorn6Maria L. Pereira7Polrat Wilairatana8Mohammed Rahmatullah9Department of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka 1207, BangladeshDepartment of Pharmacy, University of Development Alternative, Dhaka 1207, BangladeshDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka 1207, BangladeshDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka 1207, BangladeshDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka 1207, BangladeshDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka 1207, BangladeshSchool of Allied Health Sciences, World Union for Herbal Drug Discovery (WUHeDD), and Research Excellence Center for Innovation and Health Products (RECIHP), Walailak University, Nakhon Si Thammarat 80160, ThailandCICECO-Aveiro Institute of Materials & Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 73170, ThailandDepartment of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka 1207, BangladeshRheumatoid arthritis is a chronic autoimmune disorder that can lead to disability conditions with swollen joints, pain, stiffness, cartilage degradation, and osteoporosis. Genetic, epigenetic, sex-specific factors, smoking, air pollution, food, oral hygiene, periodontitis, <i>Prevotella</i>, and imbalance in the gastrointestinal microbiota are possible sources of the initiation or progression of rheumatoid arthritis, although the detailed mechanisms still need to be elucidated. Probiotics containing <i>Lactobacillus spp.</i> are commonly used as alleviating agents or food supplements to manage diarrhea, dysentery, develop immunity, and maintain general health. The mechanism of action of <i>Lactobacillus spp.</i> against rheumatoid arthritis is still not clearly known to date. In this narrative review, we recapitulate the findings of recent studies to understand the overall pathogenesis of rheumatoid arthritis and the roles of <i>probiotics,</i> particularly <i>L. casei</i> or <i>L. acidophilus,</i> in the management of rheumatoid arthritis in clinical and preclinical studies.https://www.mdpi.com/2076-2607/9/5/1070rheumatoid arthritisprobiotics<i>Lactobacillus</i><i>Prevotella</i>gut microbiota |
| spellingShingle | Alok K. Paul Anita Paul Rownak Jahan Khoshnur Jannat Tohmina A. Bondhon Anamul Hasan Veeranoot Nissapatorn Maria L. Pereira Polrat Wilairatana Mohammed Rahmatullah Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of <i>Lactobacillus casei</i> and <i>Lactobacillus acidophilus</i> Microorganisms rheumatoid arthritis probiotics <i>Lactobacillus</i> <i>Prevotella</i> gut microbiota |
| title | Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of <i>Lactobacillus casei</i> and <i>Lactobacillus acidophilus</i> |
| title_full | Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of <i>Lactobacillus casei</i> and <i>Lactobacillus acidophilus</i> |
| title_fullStr | Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of <i>Lactobacillus casei</i> and <i>Lactobacillus acidophilus</i> |
| title_full_unstemmed | Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of <i>Lactobacillus casei</i> and <i>Lactobacillus acidophilus</i> |
| title_short | Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of <i>Lactobacillus casei</i> and <i>Lactobacillus acidophilus</i> |
| title_sort | probiotics and amelioration of rheumatoid arthritis significant roles of i lactobacillus casei i and i lactobacillus acidophilus i |
| topic | rheumatoid arthritis probiotics <i>Lactobacillus</i> <i>Prevotella</i> gut microbiota |
| url | https://www.mdpi.com/2076-2607/9/5/1070 |
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