Cataract Surgery Is Not Associated with Decreased Risk of Retinal Vein Occlusion
Purpose: To evaluate whether cataract surgery is associated with decreased risks of central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO) development using the American Academy of Ophthalmology Intelligent Research in Sight (IRIS®) Registry. Design: Retrospective database stu...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-09-01
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| Series: | Ophthalmology Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666914521000397 |
| _version_ | 1818735910748946432 |
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| author | Yelena Bagdasarova, PhD Aaron Y. Lee, MD, MSCI Morgan Maring, BS Joanne Wen, MD Megan Lacy, MS Cecilia S. Lee, MD MS Andrew Chen, MD Flora Lum, MD Emily Chew, MD Suzann Pershing, MD Julia A. Haller, MD Leslie Hyman, PhD Alice C. Lorch, MD, MPH Joan W. Miller, MD |
| author_facet | Yelena Bagdasarova, PhD Aaron Y. Lee, MD, MSCI Morgan Maring, BS Joanne Wen, MD Megan Lacy, MS Cecilia S. Lee, MD MS Andrew Chen, MD Flora Lum, MD Emily Chew, MD Suzann Pershing, MD Julia A. Haller, MD Leslie Hyman, PhD Alice C. Lorch, MD, MPH Joan W. Miller, MD |
| author_sort | Yelena Bagdasarova, PhD |
| collection | DOAJ |
| description | Purpose: To evaluate whether cataract surgery is associated with decreased risks of central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO) development using the American Academy of Ophthalmology Intelligent Research in Sight (IRIS®) Registry. Design: Retrospective database study of the IRIS Registry data. Participants: Patients in the IRIS Registry who underwent cataract surgery and 1:1 matched control participants from the IRIS Registry using a decision tree classifier as a propensity model. Methods: Control and treatment groups initially were selected using Current Procedural Terminology codes for uncomplicated cataract surgery and other straightforward criteria. To accomplish treatment–control matching, a decision tree classifier was trained to classify patients as treatment versus control based on a set of chosen predictors for treatment, where best-corrected visual acuity and age were the most important predictors. Treatment and control participants subsequently were matched using the classifier, the visit dates, and the identifications of the practice. Cox regression was performed on the matched groups to measure the hazard ratio (HR) of retinal vein occlusion development adjusted for age, sex, race, primary insurance type, and previous diagnosis of diabetic retinopathy (DR), glaucoma, and narrow angles. Main Outcome Measure: The HR of retinal vein occlusion developing in patients who underwent cataract surgery compared with matched control participants. Results: The HRs for CRVO and BRVO developing in patients who underwent cataract surgery compared with matched control participants who did not during the first year after either cataract surgery or baseline visit were 1.26 [95% confidence interval [CI], 1.16–1.38; P < 0.001] and 1.27 [95% CI, 1.19–1.36; P < 0.001], respectively, after controlling for age, sex, race, insurance, and history of DR, glaucoma, and narrow angles. Diabetic retinopathy was the strongest predictor associated with CRVO (2.79 [95% CI, 2.43–3.20; P < 0.001]) and BRVO (2.35 [95% CI, 2.09–2.64; P < 0.001]) development after cataract surgery. Conclusions: Cataract surgery is associated with a small increase in risk of retinal vein occlusions within the first year; however, the incidence is low and likely not clinically significant. |
| first_indexed | 2024-12-18T00:28:46Z |
| format | Article |
| id | doaj.art-ff54fbaccc7b4333ad7e7c6e09ee9d28 |
| institution | Directory Open Access Journal |
| issn | 2666-9145 |
| language | English |
| last_indexed | 2024-12-18T00:28:46Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ophthalmology Science |
| spelling | doaj.art-ff54fbaccc7b4333ad7e7c6e09ee9d282022-12-21T21:27:11ZengElsevierOphthalmology Science2666-91452021-09-0113100041Cataract Surgery Is Not Associated with Decreased Risk of Retinal Vein OcclusionYelena Bagdasarova, PhD0Aaron Y. Lee, MD, MSCI1Morgan Maring, BS2Joanne Wen, MD3Megan Lacy, MS4Cecilia S. Lee, MD MS5Andrew Chen, MD6Flora Lum, MDEmily Chew, MDSuzann Pershing, MDJulia A. Haller, MDLeslie Hyman, PhDAlice C. Lorch, MD, MPHJoan W. Miller, MDDepartment of Ophthalmology, University of Washington, Seattle, WashingtonDepartment of Ophthalmology, University of Washington, Seattle, WashingtonKeck School of Medicine, University of Southern California, Los Angeles, CaliforniaDepartment of Ophthalmology, Duke University, Durham, North CarolinaDepartment of Ophthalmology, University of Washington, Seattle, WashingtonDepartment of Ophthalmology, University of Washington, Seattle, WashingtonDepartment of Ophthalmology, University of Washington, Seattle, Washington; Correspondence: Andrew Chen, MD, Department of Ophthalmology, University of Washington, Box 359608, 325 Ninth Avenue, Seattle, WA 98104.Purpose: To evaluate whether cataract surgery is associated with decreased risks of central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO) development using the American Academy of Ophthalmology Intelligent Research in Sight (IRIS®) Registry. Design: Retrospective database study of the IRIS Registry data. Participants: Patients in the IRIS Registry who underwent cataract surgery and 1:1 matched control participants from the IRIS Registry using a decision tree classifier as a propensity model. Methods: Control and treatment groups initially were selected using Current Procedural Terminology codes for uncomplicated cataract surgery and other straightforward criteria. To accomplish treatment–control matching, a decision tree classifier was trained to classify patients as treatment versus control based on a set of chosen predictors for treatment, where best-corrected visual acuity and age were the most important predictors. Treatment and control participants subsequently were matched using the classifier, the visit dates, and the identifications of the practice. Cox regression was performed on the matched groups to measure the hazard ratio (HR) of retinal vein occlusion development adjusted for age, sex, race, primary insurance type, and previous diagnosis of diabetic retinopathy (DR), glaucoma, and narrow angles. Main Outcome Measure: The HR of retinal vein occlusion developing in patients who underwent cataract surgery compared with matched control participants. Results: The HRs for CRVO and BRVO developing in patients who underwent cataract surgery compared with matched control participants who did not during the first year after either cataract surgery or baseline visit were 1.26 [95% confidence interval [CI], 1.16–1.38; P < 0.001] and 1.27 [95% CI, 1.19–1.36; P < 0.001], respectively, after controlling for age, sex, race, insurance, and history of DR, glaucoma, and narrow angles. Diabetic retinopathy was the strongest predictor associated with CRVO (2.79 [95% CI, 2.43–3.20; P < 0.001]) and BRVO (2.35 [95% CI, 2.09–2.64; P < 0.001]) development after cataract surgery. Conclusions: Cataract surgery is associated with a small increase in risk of retinal vein occlusions within the first year; however, the incidence is low and likely not clinically significant.http://www.sciencedirect.com/science/article/pii/S2666914521000397Branch retinal vein occlusionCataract surgeryCentral retinal vein occlusion |
| spellingShingle | Yelena Bagdasarova, PhD Aaron Y. Lee, MD, MSCI Morgan Maring, BS Joanne Wen, MD Megan Lacy, MS Cecilia S. Lee, MD MS Andrew Chen, MD Flora Lum, MD Emily Chew, MD Suzann Pershing, MD Julia A. Haller, MD Leslie Hyman, PhD Alice C. Lorch, MD, MPH Joan W. Miller, MD Cataract Surgery Is Not Associated with Decreased Risk of Retinal Vein Occlusion Ophthalmology Science Branch retinal vein occlusion Cataract surgery Central retinal vein occlusion |
| title | Cataract Surgery Is Not Associated with Decreased Risk of Retinal Vein Occlusion |
| title_full | Cataract Surgery Is Not Associated with Decreased Risk of Retinal Vein Occlusion |
| title_fullStr | Cataract Surgery Is Not Associated with Decreased Risk of Retinal Vein Occlusion |
| title_full_unstemmed | Cataract Surgery Is Not Associated with Decreased Risk of Retinal Vein Occlusion |
| title_short | Cataract Surgery Is Not Associated with Decreased Risk of Retinal Vein Occlusion |
| title_sort | cataract surgery is not associated with decreased risk of retinal vein occlusion |
| topic | Branch retinal vein occlusion Cataract surgery Central retinal vein occlusion |
| url | http://www.sciencedirect.com/science/article/pii/S2666914521000397 |
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