Immunoprofiling of monocytes in STAT1 gain-of-function chronic mucocutaneous candidiasis

Immunoprofiling of monocytes in STAT1 gain-of-function chronic mucocutaneous candidiasis

Patients with STAT1 gain-of-function (GOF) mutations suffer from an inborn error of immunity hallmarked by chronic mucocutaneous candidiasis (CMC). The pathogenesis behind this complex and heterogeneous disease is still incompletely understood. Beyond the well-recognized Th17 failure, linked to the...

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Bibliographic Details
Main Authors: Marketa Bloomfield, Irena Zentsova, Tomas Milota, Anna Sediva, Zuzana Parackova
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
candidiasis
cmc
monocytes
dendritic cell
STAT1
ruxolitinib
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.983977/full

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