Metabolomics evidence on Helicobacter pylori infection related hydroxytryptophan induced delayed immune response; an immunopathological process that increase the risk of cholangiocarcinoma
Background: Helicobacter pylori infection is an important bacterial infection that is related to chronic gastritis and gastric carcinogenesis. Recently, there is an observation that H. pylori infection can increase the risk of cholangiocarcinoma, another important gastrointestinal cancer in tropical...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Society of Diabetic Nephropathy Prevention
2019-01-01
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| Series: | Journal of Preventive Epidemiology |
| Subjects: | |
| Online Access: | http://jprevepi.com/PDF/jpe-96 |
| _version_ | 1818476796031533056 |
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| author | Somsri Wiwanitkit Viroj Wiwanitkit |
| author_facet | Somsri Wiwanitkit Viroj Wiwanitkit |
| author_sort | Somsri Wiwanitkit |
| collection | DOAJ |
| description | Background: Helicobacter pylori infection is an important bacterial infection that is related to chronic gastritis and gastric carcinogenesis. Recently, there is an observation that H. pylori infection can increase the risk of cholangiocarcinoma, another important gastrointestinal cancer in tropical Asia. Methods: The authors perform a comparative metabolomics analysis to find the common metabolomes between H. pylori infection and cholangiocarcinoma. In addition, cross interaction analysis among identified specific metabolomes from H. pylori infection and cholangiocarcinoma is done and the expression analysis to find the possible pathway relating to the carcinogenesis is done. Results: There are identified specific metabolomes from H. pylori infection and cholangiocarcinoma but there is no common metabolome. Further cross interaction analysis shows no interaction. From expression analysis, the tryptophan, a specific metabolome in H. pylori infection has the interrelationship with increased expression of tryptophan hydroxylase 1 in cholangiocarcinoma. The resulted increased hydroxytryptophan might relate to the delayed immune response that might be the underlying factor leading to the increased risk for cholangiocarcinogenesis. Conclusion: From analysis, the identified H. pylori infection related hydroxytryptophan induced delayed immune response is an explanation for the increased risk of cholangiocarcinoma. |
| first_indexed | 2024-12-10T09:29:57Z |
| format | Article |
| id | doaj.art-ff56e0ff45e54b8d9476d00ffa458174 |
| institution | Directory Open Access Journal |
| issn | 2476-3934 |
| language | English |
| last_indexed | 2024-12-10T09:29:57Z |
| publishDate | 2019-01-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Preventive Epidemiology |
| spelling | doaj.art-ff56e0ff45e54b8d9476d00ffa4581742022-12-22T01:54:23ZengSociety of Diabetic Nephropathy PreventionJournal of Preventive Epidemiology2476-39342019-01-0141e05e05jpe-96Metabolomics evidence on Helicobacter pylori infection related hydroxytryptophan induced delayed immune response; an immunopathological process that increase the risk of cholangiocarcinomaSomsri Wiwanitkit0Viroj Wiwanitkit1Medical Academic Center, Bangkok, ThailandAdjunct professor, Joseph Ayobabalola University, Ikeji-Arakeji, NigeriaBackground: Helicobacter pylori infection is an important bacterial infection that is related to chronic gastritis and gastric carcinogenesis. Recently, there is an observation that H. pylori infection can increase the risk of cholangiocarcinoma, another important gastrointestinal cancer in tropical Asia. Methods: The authors perform a comparative metabolomics analysis to find the common metabolomes between H. pylori infection and cholangiocarcinoma. In addition, cross interaction analysis among identified specific metabolomes from H. pylori infection and cholangiocarcinoma is done and the expression analysis to find the possible pathway relating to the carcinogenesis is done. Results: There are identified specific metabolomes from H. pylori infection and cholangiocarcinoma but there is no common metabolome. Further cross interaction analysis shows no interaction. From expression analysis, the tryptophan, a specific metabolome in H. pylori infection has the interrelationship with increased expression of tryptophan hydroxylase 1 in cholangiocarcinoma. The resulted increased hydroxytryptophan might relate to the delayed immune response that might be the underlying factor leading to the increased risk for cholangiocarcinogenesis. Conclusion: From analysis, the identified H. pylori infection related hydroxytryptophan induced delayed immune response is an explanation for the increased risk of cholangiocarcinoma.http://jprevepi.com/PDF/jpe-96metabolomicshelicobacter pyloricholangiocarcinomahydroxytryptophan |
| spellingShingle | Somsri Wiwanitkit Viroj Wiwanitkit Metabolomics evidence on Helicobacter pylori infection related hydroxytryptophan induced delayed immune response; an immunopathological process that increase the risk of cholangiocarcinoma Journal of Preventive Epidemiology metabolomics helicobacter pylori cholangiocarcinoma hydroxytryptophan |
| title | Metabolomics evidence on Helicobacter pylori infection related hydroxytryptophan induced delayed immune response; an immunopathological process that increase the risk of cholangiocarcinoma |
| title_full | Metabolomics evidence on Helicobacter pylori infection related hydroxytryptophan induced delayed immune response; an immunopathological process that increase the risk of cholangiocarcinoma |
| title_fullStr | Metabolomics evidence on Helicobacter pylori infection related hydroxytryptophan induced delayed immune response; an immunopathological process that increase the risk of cholangiocarcinoma |
| title_full_unstemmed | Metabolomics evidence on Helicobacter pylori infection related hydroxytryptophan induced delayed immune response; an immunopathological process that increase the risk of cholangiocarcinoma |
| title_short | Metabolomics evidence on Helicobacter pylori infection related hydroxytryptophan induced delayed immune response; an immunopathological process that increase the risk of cholangiocarcinoma |
| title_sort | metabolomics evidence on helicobacter pylori infection related hydroxytryptophan induced delayed immune response an immunopathological process that increase the risk of cholangiocarcinoma |
| topic | metabolomics helicobacter pylori cholangiocarcinoma hydroxytryptophan |
| url | http://jprevepi.com/PDF/jpe-96 |
| work_keys_str_mv | AT somsriwiwanitkit metabolomicsevidenceonhelicobacterpyloriinfectionrelatedhydroxytryptophaninduceddelayedimmuneresponseanimmunopathologicalprocessthatincreasetheriskofcholangiocarcinoma AT virojwiwanitkit metabolomicsevidenceonhelicobacterpyloriinfectionrelatedhydroxytryptophaninduceddelayedimmuneresponseanimmunopathologicalprocessthatincreasetheriskofcholangiocarcinoma |