Liquid–Solid Core-Shell Microcapsules of Calcium Carbonate Coated Emulsions and Liposomes
Micron-sized core-shell particles consisting of a calcium carbonate (CaCO<sub>3</sub>) mineral shell and a fluidic core were generated using a biomimetic approach, for the purpose of use as biodegradable microcapsules for release of active agents. Dinoflagellate cysts, unicellular organi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/23/8551 |
| _version_ | 1827701158007799808 |
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| author | Mark A. Bewernitz Archana C. Lovett Laurie B. Gower |
| author_facet | Mark A. Bewernitz Archana C. Lovett Laurie B. Gower |
| author_sort | Mark A. Bewernitz |
| collection | DOAJ |
| description | Micron-sized core-shell particles consisting of a calcium carbonate (CaCO<sub>3</sub>) mineral shell and a fluidic core were generated using a biomimetic approach, for the purpose of use as biodegradable microcapsules for release of active agents. Dinoflagellate cysts, unicellular organisms which deposit a protective hard mineral shell around their soft and fluidic cellular interior, served as our inspiration. Using the biomimetic polymer-induced liquid-precursor (PILP) mineralization process, calcium carbonate coatings were deposited on charged emulsion droplets and liposomes. Light microscopy, scanning electron microscopy, polarized light microscopy, X-ray diffraction, and confocal fluorescence microscopy were used to demonstrate that smooth CaCO<sub>3</sub> mineral coatings can be deposited onto the high curvature surfaces of emulsions and liposomes to yield micron-sized microcapsules for the effective entrapment of both hydrophobic and hydrophilic active agents. These biodegradable and biocompatible CaCO<sub>3</sub> microcapsules are novel systems for producing a powdered form of fluid-containing capsules for storage and transport of pharma/chemical agents. They may be used in lieu of, or in conjunction with, existing microcapsule delivery approaches, as well as providing a convenient foundation for which polymeric coatings could be further applied, allowing for more complex targeting and/or chemical-release control. |
| first_indexed | 2024-03-10T14:27:46Z |
| format | Article |
| id | doaj.art-ff5afb9febcb4d88b31ed44145f53fd4 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T14:27:46Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-ff5afb9febcb4d88b31ed44145f53fd42023-11-20T22:53:42ZengMDPI AGApplied Sciences2076-34172020-11-011023855110.3390/app10238551Liquid–Solid Core-Shell Microcapsules of Calcium Carbonate Coated Emulsions and LiposomesMark A. Bewernitz0Archana C. Lovett1Laurie B. Gower2Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USADepartment of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USADepartment of Materials Science and Engineering, University of Florida, Gainesville, FL 32611, USAMicron-sized core-shell particles consisting of a calcium carbonate (CaCO<sub>3</sub>) mineral shell and a fluidic core were generated using a biomimetic approach, for the purpose of use as biodegradable microcapsules for release of active agents. Dinoflagellate cysts, unicellular organisms which deposit a protective hard mineral shell around their soft and fluidic cellular interior, served as our inspiration. Using the biomimetic polymer-induced liquid-precursor (PILP) mineralization process, calcium carbonate coatings were deposited on charged emulsion droplets and liposomes. Light microscopy, scanning electron microscopy, polarized light microscopy, X-ray diffraction, and confocal fluorescence microscopy were used to demonstrate that smooth CaCO<sub>3</sub> mineral coatings can be deposited onto the high curvature surfaces of emulsions and liposomes to yield micron-sized microcapsules for the effective entrapment of both hydrophobic and hydrophilic active agents. These biodegradable and biocompatible CaCO<sub>3</sub> microcapsules are novel systems for producing a powdered form of fluid-containing capsules for storage and transport of pharma/chemical agents. They may be used in lieu of, or in conjunction with, existing microcapsule delivery approaches, as well as providing a convenient foundation for which polymeric coatings could be further applied, allowing for more complex targeting and/or chemical-release control.https://www.mdpi.com/2076-3417/10/23/8551microcapsulesbiodegradable particlesPILP processliposome coatingemulsion coatingbiomimetic processing |
| spellingShingle | Mark A. Bewernitz Archana C. Lovett Laurie B. Gower Liquid–Solid Core-Shell Microcapsules of Calcium Carbonate Coated Emulsions and Liposomes Applied Sciences microcapsules biodegradable particles PILP process liposome coating emulsion coating biomimetic processing |
| title | Liquid–Solid Core-Shell Microcapsules of Calcium Carbonate Coated Emulsions and Liposomes |
| title_full | Liquid–Solid Core-Shell Microcapsules of Calcium Carbonate Coated Emulsions and Liposomes |
| title_fullStr | Liquid–Solid Core-Shell Microcapsules of Calcium Carbonate Coated Emulsions and Liposomes |
| title_full_unstemmed | Liquid–Solid Core-Shell Microcapsules of Calcium Carbonate Coated Emulsions and Liposomes |
| title_short | Liquid–Solid Core-Shell Microcapsules of Calcium Carbonate Coated Emulsions and Liposomes |
| title_sort | liquid solid core shell microcapsules of calcium carbonate coated emulsions and liposomes |
| topic | microcapsules biodegradable particles PILP process liposome coating emulsion coating biomimetic processing |
| url | https://www.mdpi.com/2076-3417/10/23/8551 |
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