Recovery of Corneal Innervation after Treatment in Dry Eye Disease: A Confocal Microscopy Study
Purpose: To analyze the changes in corneal innervation by means of in vivo corneal confocal microscopy (IVCM) in patients diagnosed with Evaporative (EDE) and Aqueous Deficient Dry Eye (ADDE) and treated with a standard treatment for Dry Eye Disease (DED) in combination with Plasma Rich in Growth Fa...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/5/1841 |
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| author | Alberto Barros Javier Lozano-Sanroma Juan Queiruga-Piñeiro Luis Fernández-Vega Cueto Eduardo Anitua Ignacio Alcalde Jesús Merayo-Lloves |
| author_facet | Alberto Barros Javier Lozano-Sanroma Juan Queiruga-Piñeiro Luis Fernández-Vega Cueto Eduardo Anitua Ignacio Alcalde Jesús Merayo-Lloves |
| author_sort | Alberto Barros |
| collection | DOAJ |
| description | Purpose: To analyze the changes in corneal innervation by means of in vivo corneal confocal microscopy (IVCM) in patients diagnosed with Evaporative (EDE) and Aqueous Deficient Dry Eye (ADDE) and treated with a standard treatment for Dry Eye Disease (DED) in combination with Plasma Rich in Growth Factors (PRGF). Methods: Eighty-three patients diagnosed with DED were enrolled in this study and included in the EDE or ADDE subtype. The primary variables analyzed were the length, density and number of nerve branches, and the secondary variables were those related to the quantity and stability of the tear film and the subjective response of the patients measured with psychometric questionnaires. Results: The combined treatment therapy with PRGF outperforms the standard treatment therapy in terms of subbasal nerve plexus regeneration, significantly increasing length, number of branches and nerve density, as well as significantly improving the stability of the tear film (<i>p</i> < 0.05 for all of them), and the most significant changes were located in the ADDE subtype. Conclusions: the corneal reinnervation process responds in a different way depending on the treatment prescribed and the subtype of dry eye disease. In vivo confocal microscopy is presented as a powerful technique in the diagnosis and management of neurosensory abnormalities in DED. |
| first_indexed | 2024-03-11T07:21:09Z |
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| id | doaj.art-ff5e5199e5a34e2ab18b22734f61c67d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T07:21:09Z |
| publishDate | 2023-02-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-ff5e5199e5a34e2ab18b22734f61c67d2023-11-17T07:59:05ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125184110.3390/jcm12051841Recovery of Corneal Innervation after Treatment in Dry Eye Disease: A Confocal Microscopy StudyAlberto Barros0Javier Lozano-Sanroma1Juan Queiruga-Piñeiro2Luis Fernández-Vega Cueto3Eduardo Anitua4Ignacio Alcalde5Jesús Merayo-Lloves6Instituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universidad de Oviedo, 33012 Oviedo, SpainInstituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universidad de Oviedo, 33012 Oviedo, SpainInstituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universidad de Oviedo, 33012 Oviedo, SpainInstituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universidad de Oviedo, 33012 Oviedo, SpainBiotechnology Institute (BTI), 01007 Vitoria, SpainInstituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universidad de Oviedo, 33012 Oviedo, SpainInstituto Universitario Fernández-Vega, Fundación de Investigación Oftalmológica, Universidad de Oviedo, 33012 Oviedo, SpainPurpose: To analyze the changes in corneal innervation by means of in vivo corneal confocal microscopy (IVCM) in patients diagnosed with Evaporative (EDE) and Aqueous Deficient Dry Eye (ADDE) and treated with a standard treatment for Dry Eye Disease (DED) in combination with Plasma Rich in Growth Factors (PRGF). Methods: Eighty-three patients diagnosed with DED were enrolled in this study and included in the EDE or ADDE subtype. The primary variables analyzed were the length, density and number of nerve branches, and the secondary variables were those related to the quantity and stability of the tear film and the subjective response of the patients measured with psychometric questionnaires. Results: The combined treatment therapy with PRGF outperforms the standard treatment therapy in terms of subbasal nerve plexus regeneration, significantly increasing length, number of branches and nerve density, as well as significantly improving the stability of the tear film (<i>p</i> < 0.05 for all of them), and the most significant changes were located in the ADDE subtype. Conclusions: the corneal reinnervation process responds in a different way depending on the treatment prescribed and the subtype of dry eye disease. In vivo confocal microscopy is presented as a powerful technique in the diagnosis and management of neurosensory abnormalities in DED.https://www.mdpi.com/2077-0383/12/5/1841corneal nervescorneal confocal microscopydry eye disease |
| spellingShingle | Alberto Barros Javier Lozano-Sanroma Juan Queiruga-Piñeiro Luis Fernández-Vega Cueto Eduardo Anitua Ignacio Alcalde Jesús Merayo-Lloves Recovery of Corneal Innervation after Treatment in Dry Eye Disease: A Confocal Microscopy Study Journal of Clinical Medicine corneal nerves corneal confocal microscopy dry eye disease |
| title | Recovery of Corneal Innervation after Treatment in Dry Eye Disease: A Confocal Microscopy Study |
| title_full | Recovery of Corneal Innervation after Treatment in Dry Eye Disease: A Confocal Microscopy Study |
| title_fullStr | Recovery of Corneal Innervation after Treatment in Dry Eye Disease: A Confocal Microscopy Study |
| title_full_unstemmed | Recovery of Corneal Innervation after Treatment in Dry Eye Disease: A Confocal Microscopy Study |
| title_short | Recovery of Corneal Innervation after Treatment in Dry Eye Disease: A Confocal Microscopy Study |
| title_sort | recovery of corneal innervation after treatment in dry eye disease a confocal microscopy study |
| topic | corneal nerves corneal confocal microscopy dry eye disease |
| url | https://www.mdpi.com/2077-0383/12/5/1841 |
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