Antiproliferative Activity and Antioxidant Potential of Extracts of <i>Garcinia gardneriana</i>
The aim of this study was to evaluate the antiproliferative activity, the antioxidant potential, and the chemical profile obtained from the whole fruit and from leaves of <i>Garcinia gardneriana</i>, a fruit tree from Brazilian Cerrado. To determine in vitro antiproliferative activity, t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/14/3201 |
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| author | Simone da Cunha Demenciano Magalli Costa Barbosa Lima e Silva Caroline Almeida Farias Alexandrino Wilson Hino Kato Junior Patrícia de Oliveira Figueiredo Walmir Silva Garcez Raquel Pires Campos Rita de Cássia Avellaneda Guimarães Ulana Chaves Sarmento Danielle Bogo |
| author_facet | Simone da Cunha Demenciano Magalli Costa Barbosa Lima e Silva Caroline Almeida Farias Alexandrino Wilson Hino Kato Junior Patrícia de Oliveira Figueiredo Walmir Silva Garcez Raquel Pires Campos Rita de Cássia Avellaneda Guimarães Ulana Chaves Sarmento Danielle Bogo |
| author_sort | Simone da Cunha Demenciano |
| collection | DOAJ |
| description | The aim of this study was to evaluate the antiproliferative activity, the antioxidant potential, and the chemical profile obtained from the whole fruit and from leaves of <i>Garcinia gardneriana</i>, a fruit tree from Brazilian Cerrado. To determine in vitro antiproliferative activity, the following neoplastic cell lines were considered, along with an immortalized nontumor cell line. The antioxidant potential was determined, and the evaluation of antiradical air activity was performed. The levels of vitamin C and carotenoids were determined. The chemical profile was analyzed by high-performance liquid chromatography coupled to a diode array detector and a mass spectrometer using electrospray ionization interface. The chloroform fraction of the leaf showed antioxidant activity. The vitamin C content had lower values in fruits and higher in leaves. The content of carotenoids for fruits and leaves was expressive. The ethanolic extract and the hexane and chloroform fractions of fruits were active in all neoplastic lines tested. The leaves showed cytotoxic activity in the hexane fraction in the breast carcinoma line. The analysis of data obtained verified the presence of dimers, monomers, and tetramers of hexoses, polycarboxylic acids, xanthones, flavonoids, biflavonoids, and benzophenones. |
| first_indexed | 2024-03-10T18:31:09Z |
| format | Article |
| id | doaj.art-ff5ec7b942c14a8ba2ae47eee39b4cb7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T18:31:09Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ff5ec7b942c14a8ba2ae47eee39b4cb72023-11-20T06:41:08ZengMDPI AGMolecules1420-30492020-07-012514320110.3390/molecules25143201Antiproliferative Activity and Antioxidant Potential of Extracts of <i>Garcinia gardneriana</i>Simone da Cunha Demenciano0Magalli Costa Barbosa Lima e Silva1Caroline Almeida Farias Alexandrino2Wilson Hino Kato Junior3Patrícia de Oliveira Figueiredo4Walmir Silva Garcez5Raquel Pires Campos6Rita de Cássia Avellaneda Guimarães7Ulana Chaves Sarmento8Danielle Bogo9Molecular Biology and Cell Culture Laboratory, School of Pharmaceutical Sciences, Foods and Nutrition (Facfan), Federal University of Mato Grosso do Sul (UFMS), Cidade Universitária, Campo Grande 79070-900, BrazilMolecular Biology and Cell Culture Laboratory, School of Pharmaceutical Sciences, Foods and Nutrition (Facfan), Federal University of Mato Grosso do Sul (UFMS), Cidade Universitária, Campo Grande 79070-900, BrazilMolecular Biology and Cell Culture Laboratory, School of Pharmaceutical Sciences, Foods and Nutrition (Facfan), Federal University of Mato Grosso do Sul (UFMS), Cidade Universitária, Campo Grande 79070-900, BrazilLaboratory PRONABio (Laboratory of Bioactive Natural Products)—Chemistry Institute, Federal University of Mato Grosso do Sul, Cidade Universitária, Campo Grande 79070-900, BrazilLaboratory PRONABio (Laboratory of Bioactive Natural Products)—Chemistry Institute, Federal University of Mato Grosso do Sul, Cidade Universitária, Campo Grande 79070-900, BrazilGraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, BrazilLaboratory PRONABio (Laboratory of Bioactive Natural Products)—Chemistry Institute, Federal University of Mato Grosso do Sul, Cidade Universitária, Campo Grande 79070-900, BrazilGraduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, BrazilLaboratory of Physical Chemistry of Foods, School of Pharmaceutical Sciences, Foods, Federal University of Mato Grosso do Sul (UFMS), Cidade Universitária, Campo Grande 79070-900, BrazilMolecular Biology and Cell Culture Laboratory, School of Pharmaceutical Sciences, Foods and Nutrition (Facfan), Federal University of Mato Grosso do Sul (UFMS), Cidade Universitária, Campo Grande 79070-900, BrazilThe aim of this study was to evaluate the antiproliferative activity, the antioxidant potential, and the chemical profile obtained from the whole fruit and from leaves of <i>Garcinia gardneriana</i>, a fruit tree from Brazilian Cerrado. To determine in vitro antiproliferative activity, the following neoplastic cell lines were considered, along with an immortalized nontumor cell line. The antioxidant potential was determined, and the evaluation of antiradical air activity was performed. The levels of vitamin C and carotenoids were determined. The chemical profile was analyzed by high-performance liquid chromatography coupled to a diode array detector and a mass spectrometer using electrospray ionization interface. The chloroform fraction of the leaf showed antioxidant activity. The vitamin C content had lower values in fruits and higher in leaves. The content of carotenoids for fruits and leaves was expressive. The ethanolic extract and the hexane and chloroform fractions of fruits were active in all neoplastic lines tested. The leaves showed cytotoxic activity in the hexane fraction in the breast carcinoma line. The analysis of data obtained verified the presence of dimers, monomers, and tetramers of hexoses, polycarboxylic acids, xanthones, flavonoids, biflavonoids, and benzophenones.https://www.mdpi.com/1420-3049/25/14/3201bacuparianticancerHPLC-DAD-MSbrazilian cerrado fruitscytotoxicity |
| spellingShingle | Simone da Cunha Demenciano Magalli Costa Barbosa Lima e Silva Caroline Almeida Farias Alexandrino Wilson Hino Kato Junior Patrícia de Oliveira Figueiredo Walmir Silva Garcez Raquel Pires Campos Rita de Cássia Avellaneda Guimarães Ulana Chaves Sarmento Danielle Bogo Antiproliferative Activity and Antioxidant Potential of Extracts of <i>Garcinia gardneriana</i> Molecules bacupari anticancer HPLC-DAD-MS brazilian cerrado fruits cytotoxicity |
| title | Antiproliferative Activity and Antioxidant Potential of Extracts of <i>Garcinia gardneriana</i> |
| title_full | Antiproliferative Activity and Antioxidant Potential of Extracts of <i>Garcinia gardneriana</i> |
| title_fullStr | Antiproliferative Activity and Antioxidant Potential of Extracts of <i>Garcinia gardneriana</i> |
| title_full_unstemmed | Antiproliferative Activity and Antioxidant Potential of Extracts of <i>Garcinia gardneriana</i> |
| title_short | Antiproliferative Activity and Antioxidant Potential of Extracts of <i>Garcinia gardneriana</i> |
| title_sort | antiproliferative activity and antioxidant potential of extracts of i garcinia gardneriana i |
| topic | bacupari anticancer HPLC-DAD-MS brazilian cerrado fruits cytotoxicity |
| url | https://www.mdpi.com/1420-3049/25/14/3201 |
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