Factors associated with intensive care admission in patients with lung cancer: a population-based observational study of 26, 731 patients
Abstract Background Lung cancer is the most common cause of cancer related death worldwide and survival is poor. Patients with lung cancer may develop a critical illness, but it is unclear what features are associated with an Intensive Care Unit (ICU) admission. Methods This retrospective, observati...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | BMC Pulmonary Medicine |
| Online Access: | https://doi.org/10.1186/s12890-020-1071-8 |
| _version_ | 1818969446473007104 |
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| author | Kathryn Puxty Christopher H. Grant Philip McLoone Billy Sloan Tara Quasim Kate Hulse David S. Morrison |
| author_facet | Kathryn Puxty Christopher H. Grant Philip McLoone Billy Sloan Tara Quasim Kate Hulse David S. Morrison |
| author_sort | Kathryn Puxty |
| collection | DOAJ |
| description | Abstract Background Lung cancer is the most common cause of cancer related death worldwide and survival is poor. Patients with lung cancer may develop a critical illness, but it is unclear what features are associated with an Intensive Care Unit (ICU) admission. Methods This retrospective, observational, population-based study of linked cancer registration, ICU, hospital discharge and mortality data described the factors associated with ICU admission in patients with lung cancer. The cohort comprised all incident cases of adult lung cancer diagnosed between 1st January 2000 and 31st December 2009 in the West of Scotland, UK, who were subsequently admitted to an ICU within 2 years of cancer diagnosis. Multiple logistic regression was used to determine factors associated with admission. Results 26,731 incident cases of lung cancer were diagnosed with 398 (1.5%) patients admitted to an ICU. Patients were most commonly admitted with respiratory conditions and there was a high rate of invasive mechanical ventilation. ICU, in-hospital and six-month survival were 58.5, 42.0 and 31.2%, respectively. Surgical treatment of lung cancer increased the odds of ICU admission (OR 7.23 (5.14–10.2)). Odds of admission to ICU were reduced with older age (75-80 years OR 0.69 (0.49–0.94), > 80 years OR 0.21 (0.12–0.37)), female gender (OR 0.73 (0.59–0.90)) and radiotherapy (OR 0.54 (0.39–0.73)) or chemotherapy treatment (OR 0.52 (0.38–0.70)). Conclusion 1.5% of patients diagnosed with lung cancer are admitted to an ICU but both short term and long term survival was poor. Factors associated with ICU admission included age < 75 years, male gender and surgical treatment of cancer |
| first_indexed | 2024-12-20T14:20:43Z |
| format | Article |
| id | doaj.art-ff5fff8b9d2c4348b7a49c0b224cb6a3 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-20T14:20:43Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-ff5fff8b9d2c4348b7a49c0b224cb6a32022-12-21T19:37:56ZengBMCBMC Pulmonary Medicine1471-24662020-02-012011810.1186/s12890-020-1071-8Factors associated with intensive care admission in patients with lung cancer: a population-based observational study of 26, 731 patientsKathryn Puxty0Christopher H. Grant1Philip McLoone2Billy Sloan3Tara Quasim4Kate Hulse5David S. Morrison6Academic department of Anaesthesia, Critical Care and Pain, College of Medical, Veterinary and Life Sciences, University of GlasgowAcademic department of Anaesthesia, Critical Care and Pain, College of Medical, Veterinary and Life Sciences, University of GlasgowDepartment of Public Health, College of Medical, Veterinary and Life Sciences, University of GlasgowDepartment of Public Health, College of Medical, Veterinary and Life Sciences, University of GlasgowAcademic department of Anaesthesia, Critical Care and Pain, College of Medical, Veterinary and Life Sciences, University of GlasgowAcademic department of Anaesthesia, Critical Care and Pain, College of Medical, Veterinary and Life Sciences, University of GlasgowDepartment of Public Health, College of Medical, Veterinary and Life Sciences, University of GlasgowAbstract Background Lung cancer is the most common cause of cancer related death worldwide and survival is poor. Patients with lung cancer may develop a critical illness, but it is unclear what features are associated with an Intensive Care Unit (ICU) admission. Methods This retrospective, observational, population-based study of linked cancer registration, ICU, hospital discharge and mortality data described the factors associated with ICU admission in patients with lung cancer. The cohort comprised all incident cases of adult lung cancer diagnosed between 1st January 2000 and 31st December 2009 in the West of Scotland, UK, who were subsequently admitted to an ICU within 2 years of cancer diagnosis. Multiple logistic regression was used to determine factors associated with admission. Results 26,731 incident cases of lung cancer were diagnosed with 398 (1.5%) patients admitted to an ICU. Patients were most commonly admitted with respiratory conditions and there was a high rate of invasive mechanical ventilation. ICU, in-hospital and six-month survival were 58.5, 42.0 and 31.2%, respectively. Surgical treatment of lung cancer increased the odds of ICU admission (OR 7.23 (5.14–10.2)). Odds of admission to ICU were reduced with older age (75-80 years OR 0.69 (0.49–0.94), > 80 years OR 0.21 (0.12–0.37)), female gender (OR 0.73 (0.59–0.90)) and radiotherapy (OR 0.54 (0.39–0.73)) or chemotherapy treatment (OR 0.52 (0.38–0.70)). Conclusion 1.5% of patients diagnosed with lung cancer are admitted to an ICU but both short term and long term survival was poor. Factors associated with ICU admission included age < 75 years, male gender and surgical treatment of cancerhttps://doi.org/10.1186/s12890-020-1071-8 |
| spellingShingle | Kathryn Puxty Christopher H. Grant Philip McLoone Billy Sloan Tara Quasim Kate Hulse David S. Morrison Factors associated with intensive care admission in patients with lung cancer: a population-based observational study of 26, 731 patients BMC Pulmonary Medicine |
| title | Factors associated with intensive care admission in patients with lung cancer: a population-based observational study of 26, 731 patients |
| title_full | Factors associated with intensive care admission in patients with lung cancer: a population-based observational study of 26, 731 patients |
| title_fullStr | Factors associated with intensive care admission in patients with lung cancer: a population-based observational study of 26, 731 patients |
| title_full_unstemmed | Factors associated with intensive care admission in patients with lung cancer: a population-based observational study of 26, 731 patients |
| title_short | Factors associated with intensive care admission in patients with lung cancer: a population-based observational study of 26, 731 patients |
| title_sort | factors associated with intensive care admission in patients with lung cancer a population based observational study of 26 731 patients |
| url | https://doi.org/10.1186/s12890-020-1071-8 |
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