Intranasal Lidocaine for Primary Headache Management in Emergency Department; a Clinical Trial
<p><strong>Introduction:</strong> Most of the headache cases only require pain management in emergency department (ED). The present study aimed to evaluate the efficacy of intranasal lidocaine in this regard. <strong>Method:</strong> In this clinical trial, adult patien...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Shahid Beheshti University of Medical Sciences
2017-01-01
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| Series: | Emergency |
| Subjects: | |
| Online Access: | http://journals.sbmu.ac.ir/emergency/article/view/18533 |
| _version_ | 1818159658220650496 |
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| author | Hassan Barzegari Hassan Motamed Behrad Ziapour Majid Hajimohammadi Mina Kadkhodazadeh |
| author_facet | Hassan Barzegari Hassan Motamed Behrad Ziapour Majid Hajimohammadi Mina Kadkhodazadeh |
| author_sort | Hassan Barzegari |
| collection | DOAJ |
| description | <p><strong>Introduction:</strong> Most of the headache cases only require pain management in emergency department (ED). The present study aimed to evaluate the efficacy of intranasal lidocaine in this regard. <strong>Method:</strong> In this clinical trial, adult patients with primary headache were randomly treated with 7.5 mg intravenous (IV) chlorpromazine and 1 ml intranasal lidocaine 2% (treatment) or normal saline 0.9% (placebo), and were compared 5, 15, and 30 minutes later regarding success rate using SPSS 21. <strong>Result:</strong> 100 patients were assigned to either treatment or placebo group. Number needed to treat of intranasal lidocaine at 5, 15, and 30 minutes were 4 (95% CI: 2.2 – 6.6), 3 (95% CI: 1.7 – 3.5), and 4 (95% CI: 2.3 – 15.9), respectively. These measures for absolute risk reduction were 30 (95% CI: 15.2 – 44.8), 44 (95% CI: 28.7 – 59.3), and 26 percent (95% CI: 6.3 – 44.3), respectively. Pain relapse occurred in 16% of treatment and 11% of control group within 1 hour of treatment (p = 0.402). <strong>Conclusion: </strong>It seems that,<strong> </strong>intranasal lidocaine along with IV chlorpromazine could result in more successful and faster management of primary headaches in ED. </p> |
| first_indexed | 2024-12-11T15:49:29Z |
| format | Article |
| id | doaj.art-ff6016b86a9141678fa0c8666b4a8a44 |
| institution | Directory Open Access Journal |
| issn | 2345-4563 2345-4571 |
| language | English |
| last_indexed | 2024-12-11T15:49:29Z |
| publishDate | 2017-01-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Emergency |
| spelling | doaj.art-ff6016b86a9141678fa0c8666b4a8a442022-12-22T00:59:37ZengShahid Beheshti University of Medical SciencesEmergency2345-45632345-45712017-01-0151e79e7910.22037/emergency.v5i1.185339350Intranasal Lidocaine for Primary Headache Management in Emergency Department; a Clinical TrialHassan Barzegari0Hassan Motamed1Behrad Ziapour2Majid Hajimohammadi3Mina Kadkhodazadeh4Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Emergency Medicine Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.<p><strong>Introduction:</strong> Most of the headache cases only require pain management in emergency department (ED). The present study aimed to evaluate the efficacy of intranasal lidocaine in this regard. <strong>Method:</strong> In this clinical trial, adult patients with primary headache were randomly treated with 7.5 mg intravenous (IV) chlorpromazine and 1 ml intranasal lidocaine 2% (treatment) or normal saline 0.9% (placebo), and were compared 5, 15, and 30 minutes later regarding success rate using SPSS 21. <strong>Result:</strong> 100 patients were assigned to either treatment or placebo group. Number needed to treat of intranasal lidocaine at 5, 15, and 30 minutes were 4 (95% CI: 2.2 – 6.6), 3 (95% CI: 1.7 – 3.5), and 4 (95% CI: 2.3 – 15.9), respectively. These measures for absolute risk reduction were 30 (95% CI: 15.2 – 44.8), 44 (95% CI: 28.7 – 59.3), and 26 percent (95% CI: 6.3 – 44.3), respectively. Pain relapse occurred in 16% of treatment and 11% of control group within 1 hour of treatment (p = 0.402). <strong>Conclusion: </strong>It seems that,<strong> </strong>intranasal lidocaine along with IV chlorpromazine could result in more successful and faster management of primary headaches in ED. </p>http://journals.sbmu.ac.ir/emergency/article/view/18533Pain managementtension-type Headacheadministration, intranasallidocainemigraine disorders |
| spellingShingle | Hassan Barzegari Hassan Motamed Behrad Ziapour Majid Hajimohammadi Mina Kadkhodazadeh Intranasal Lidocaine for Primary Headache Management in Emergency Department; a Clinical Trial Emergency Pain management tension-type Headache administration, intranasal lidocaine migraine disorders |
| title | Intranasal Lidocaine for Primary Headache Management in Emergency Department; a Clinical Trial |
| title_full | Intranasal Lidocaine for Primary Headache Management in Emergency Department; a Clinical Trial |
| title_fullStr | Intranasal Lidocaine for Primary Headache Management in Emergency Department; a Clinical Trial |
| title_full_unstemmed | Intranasal Lidocaine for Primary Headache Management in Emergency Department; a Clinical Trial |
| title_short | Intranasal Lidocaine for Primary Headache Management in Emergency Department; a Clinical Trial |
| title_sort | intranasal lidocaine for primary headache management in emergency department a clinical trial |
| topic | Pain management tension-type Headache administration, intranasal lidocaine migraine disorders |
| url | http://journals.sbmu.ac.ir/emergency/article/view/18533 |
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