Antibiotics for preventing infection at the surgical site: Single dose vs. multiple doses
Background: Surgical site infections are common and expensive infections that can cause fatalities or poor patient outcomes. To prevent these infections, antibiotic prophylaxis is used. However, excessive antibiotic use is related to higher costs and the emergence of antimicrobial resistance. Object...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Saudi Pharmaceutical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016423002955 |
| _version_ | 1797390587864809472 |
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| author | Nehad J. Ahmed Abdul Haseeb, PhD Abdullmoin AlQarni Manal AlGethamy Ahmad J. Mahrous Ahmed M. Alshehri Abdullah K Alahmari Safa S. Almarzoky Abuhussain Ahmed Mohammed Ashraf Bashawri Amer H. Khan |
| author_facet | Nehad J. Ahmed Abdul Haseeb, PhD Abdullmoin AlQarni Manal AlGethamy Ahmad J. Mahrous Ahmed M. Alshehri Abdullah K Alahmari Safa S. Almarzoky Abuhussain Ahmed Mohammed Ashraf Bashawri Amer H. Khan |
| author_sort | Nehad J. Ahmed |
| collection | DOAJ |
| description | Background: Surgical site infections are common and expensive infections that can cause fatalities or poor patient outcomes. To prevent these infections, antibiotic prophylaxis is used. However, excessive antibiotic use is related to higher costs and the emergence of antimicrobial resistance. Objectives: The present meta-analysis aimed to compare the effectiveness of a single dosage versus several doses of antibiotics in preventing the development of surgical site infections. Methods: PubMed was used to find clinical trials evaluating the effectiveness of a single dosage versus several doses of antibiotics in avoiding the development of surgical site infections. The study included trials that were published between 1984 and 2022. Seventy-four clinical trials were included in the analysis. Odds ratios were used to compare groups with 95% confidence intervals. The data were displayed using OR to generate a forest plot. Review Manager (RevMan version 5.4) was used to do the meta-analysis. Results: Regarding clean operations, there were 389 surgical site infections out of 5,634 patients in a single dose group (6.90%) and 349 surgical site infections out of 5,621 patients in multiple doses group (6.21%) (OR = 1.11, lower CI = 0.95, upper CI = 1.30). Regarding clean-contaminated operations, there were 137 surgical site infections out of 2,715 patients in a single dose group (5.05%) and 137 surgical site infections out of 2,355 patients in multiple doses group (5.82%) (OR = 0.87, lower CI = 0.68, upper CI = 1.11). Regarding contaminated operations, there were 302 surgical site infections out of 3,262 patients in a single dose group (9.26%) and 276 surgical site infections out of 3,212 patients in multiple doses group (8.59%) (OR = 1.11, lower CI = 0.84, upper CI = 1.47). In general, there were 828 surgical site infections out of 11,611 patients in a single dose group (7.13%) and 762 surgical site infections out of 11,188 patients in multiple doses group (6.81%) (OR = 1.05, lower CI = 0.93, upper CI = 1.20). The difference between groups was not significant. Conclusion: The present study showed that using a single-dose antimicrobial prophylaxis was equally effective as using multiple doses of antibiotics in decreasing surgical site infections. |
| first_indexed | 2024-03-08T23:14:01Z |
| format | Article |
| id | doaj.art-ff6208f846b14c3daa324ee87a2e816e |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-03-08T23:14:01Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-ff6208f846b14c3daa324ee87a2e816e2023-12-15T07:22:52ZengElsevierSaudi Pharmaceutical Journal1319-01642023-12-013112101800Antibiotics for preventing infection at the surgical site: Single dose vs. multiple dosesNehad J. Ahmed0Abdul Haseeb, PhD1Abdullmoin AlQarni2Manal AlGethamy3Ahmad J. Mahrous4Ahmed M. Alshehri5Abdullah K Alahmari6Safa S. Almarzoky Abuhussain7Ahmed Mohammed Ashraf Bashawri8Amer H. Khan9Department of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia; Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia; Corresponding authors at: Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.Department of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi ArabiaInfectious Diseases Department, Alnoor Specialist Hospital, Makkah, Saudi ArabiaDepartment of Infection Prevention & Control Program, Alnoor Specialist Hospital Makkah, Makkah, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi ArabiaCMO, Healthcare Cluster, Ministry of Health, Makkah, Saudi ArabiaDiscipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia; Corresponding authors at: Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.Background: Surgical site infections are common and expensive infections that can cause fatalities or poor patient outcomes. To prevent these infections, antibiotic prophylaxis is used. However, excessive antibiotic use is related to higher costs and the emergence of antimicrobial resistance. Objectives: The present meta-analysis aimed to compare the effectiveness of a single dosage versus several doses of antibiotics in preventing the development of surgical site infections. Methods: PubMed was used to find clinical trials evaluating the effectiveness of a single dosage versus several doses of antibiotics in avoiding the development of surgical site infections. The study included trials that were published between 1984 and 2022. Seventy-four clinical trials were included in the analysis. Odds ratios were used to compare groups with 95% confidence intervals. The data were displayed using OR to generate a forest plot. Review Manager (RevMan version 5.4) was used to do the meta-analysis. Results: Regarding clean operations, there were 389 surgical site infections out of 5,634 patients in a single dose group (6.90%) and 349 surgical site infections out of 5,621 patients in multiple doses group (6.21%) (OR = 1.11, lower CI = 0.95, upper CI = 1.30). Regarding clean-contaminated operations, there were 137 surgical site infections out of 2,715 patients in a single dose group (5.05%) and 137 surgical site infections out of 2,355 patients in multiple doses group (5.82%) (OR = 0.87, lower CI = 0.68, upper CI = 1.11). Regarding contaminated operations, there were 302 surgical site infections out of 3,262 patients in a single dose group (9.26%) and 276 surgical site infections out of 3,212 patients in multiple doses group (8.59%) (OR = 1.11, lower CI = 0.84, upper CI = 1.47). In general, there were 828 surgical site infections out of 11,611 patients in a single dose group (7.13%) and 762 surgical site infections out of 11,188 patients in multiple doses group (6.81%) (OR = 1.05, lower CI = 0.93, upper CI = 1.20). The difference between groups was not significant. Conclusion: The present study showed that using a single-dose antimicrobial prophylaxis was equally effective as using multiple doses of antibiotics in decreasing surgical site infections.http://www.sciencedirect.com/science/article/pii/S1319016423002955AntibioticsClinical TrialsMultiple DosesSingle DoseSurgical Site Infections |
| spellingShingle | Nehad J. Ahmed Abdul Haseeb, PhD Abdullmoin AlQarni Manal AlGethamy Ahmad J. Mahrous Ahmed M. Alshehri Abdullah K Alahmari Safa S. Almarzoky Abuhussain Ahmed Mohammed Ashraf Bashawri Amer H. Khan Antibiotics for preventing infection at the surgical site: Single dose vs. multiple doses Saudi Pharmaceutical Journal Antibiotics Clinical Trials Multiple Doses Single Dose Surgical Site Infections |
| title | Antibiotics for preventing infection at the surgical site: Single dose vs. multiple doses |
| title_full | Antibiotics for preventing infection at the surgical site: Single dose vs. multiple doses |
| title_fullStr | Antibiotics for preventing infection at the surgical site: Single dose vs. multiple doses |
| title_full_unstemmed | Antibiotics for preventing infection at the surgical site: Single dose vs. multiple doses |
| title_short | Antibiotics for preventing infection at the surgical site: Single dose vs. multiple doses |
| title_sort | antibiotics for preventing infection at the surgical site single dose vs multiple doses |
| topic | Antibiotics Clinical Trials Multiple Doses Single Dose Surgical Site Infections |
| url | http://www.sciencedirect.com/science/article/pii/S1319016423002955 |
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