Case Report: Complete tomographic resolution of focal choroidal excavation complicated with choroidal neovascularization after anti-VEGF treatment [version 1; peer review: 2 approved]
Purpose: We report a case of focal choroidal excavation (FCE) that resolved after intravitreal injection of anti-vascular endothelial growth factor (VEGF) for choroidal neovascularization (CNV) and we describe its tomographic features. Case report: A 43-year-old female presented with blurred vision...
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| Format: | Article |
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F1000 Research Ltd
2023-10-01
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| Online Access: | https://f1000research.com/articles/12-1270/v1 |
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| author | Raja Zhioua Manel Mokrani Ilhem Mili Mejdi Boukari Imène Zhioua Braham Selim Haddar |
| author_facet | Raja Zhioua Manel Mokrani Ilhem Mili Mejdi Boukari Imène Zhioua Braham Selim Haddar |
| author_sort | Raja Zhioua |
| collection | DOAJ |
| description | Purpose: We report a case of focal choroidal excavation (FCE) that resolved after intravitreal injection of anti-vascular endothelial growth factor (VEGF) for choroidal neovascularization (CNV) and we describe its tomographic features. Case report: A 43-year-old female presented with blurred vision and metamorphopsia in her left eye (LE) evolving for 10 years. The best corrected visual acuity (BCVA) was 20/20 in the right eye and 20/32 in the LE. Fundus examination revealed the presence of a yellowish foveal lesion which corresponded to a conforming FCE associated to a pachychoroid on swept-source optical coherence tomography (OCT). The OCT-Angiography showed a foveal flow void in the choriocapillaris layer corresponding to the FCE area. Three years later, the patient complained of visual impairment, more metamorphopsia with a BCVA of 20/80 on her LE. The OCT showed intraretinal fluid with a foveal retinal pigment epithelium (RPE) detachment. The OCT-angiography confirmed the presence of CNV. Two months after one intravitreal bevacizumab injection, the OCT documented the complete resolution of macular edema, the regression of the CNV tissue and the restoration of a normal aspect of the fovea without any FCE. Her BCVA improved to 20/32 with resolution of the metamorphopsia. The OCT aspect remained stable during 3 years of follow-up. Conclusion: CNV can develop in FCE and anti-VEGF therapy is a good option treatment. After treatment, FCE pattern can change et may completely resolve. |
| first_indexed | 2024-04-24T21:46:25Z |
| format | Article |
| id | doaj.art-ff64baf804124421b7c24c704c3ca302 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-24T21:46:25Z |
| publishDate | 2023-10-01 |
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| series | F1000Research |
| spelling | doaj.art-ff64baf804124421b7c24c704c3ca3022024-03-21T01:00:03ZengF1000 Research LtdF1000Research2046-14022023-10-0112154513Case Report: Complete tomographic resolution of focal choroidal excavation complicated with choroidal neovascularization after anti-VEGF treatment [version 1; peer review: 2 approved]Raja Zhioua0Manel Mokrani1Ilhem Mili2Mejdi Boukari3Imène Zhioua Braham4https://orcid.org/0000-0002-8911-0139Selim Haddar5Ophthalmology, Charles Nicolle University Hospital, Tunis, Tunis, TunisiaOphthalmology, Charles Nicolle University Hospital, Tunis, Tunis, TunisiaOphthalmology, Charles Nicolle University Hospital, Tunis, Tunis, TunisiaOphthalmology, Charles Nicolle University Hospital, Tunis, Tunis, TunisiaOphthalmology, Charles Nicolle University Hospital, Tunis, Tunis, TunisiaOphthalmology, Charles Nicolle University Hospital, Tunis, Tunis, TunisiaPurpose: We report a case of focal choroidal excavation (FCE) that resolved after intravitreal injection of anti-vascular endothelial growth factor (VEGF) for choroidal neovascularization (CNV) and we describe its tomographic features. Case report: A 43-year-old female presented with blurred vision and metamorphopsia in her left eye (LE) evolving for 10 years. The best corrected visual acuity (BCVA) was 20/20 in the right eye and 20/32 in the LE. Fundus examination revealed the presence of a yellowish foveal lesion which corresponded to a conforming FCE associated to a pachychoroid on swept-source optical coherence tomography (OCT). The OCT-Angiography showed a foveal flow void in the choriocapillaris layer corresponding to the FCE area. Three years later, the patient complained of visual impairment, more metamorphopsia with a BCVA of 20/80 on her LE. The OCT showed intraretinal fluid with a foveal retinal pigment epithelium (RPE) detachment. The OCT-angiography confirmed the presence of CNV. Two months after one intravitreal bevacizumab injection, the OCT documented the complete resolution of macular edema, the regression of the CNV tissue and the restoration of a normal aspect of the fovea without any FCE. Her BCVA improved to 20/32 with resolution of the metamorphopsia. The OCT aspect remained stable during 3 years of follow-up. Conclusion: CNV can develop in FCE and anti-VEGF therapy is a good option treatment. After treatment, FCE pattern can change et may completely resolve.https://f1000research.com/articles/12-1270/v1focal choroidal excavation optical coherence tomography choroidal neovascularizationeng |
| spellingShingle | Raja Zhioua Manel Mokrani Ilhem Mili Mejdi Boukari Imène Zhioua Braham Selim Haddar Case Report: Complete tomographic resolution of focal choroidal excavation complicated with choroidal neovascularization after anti-VEGF treatment [version 1; peer review: 2 approved] F1000Research focal choroidal excavation optical coherence tomography choroidal neovascularization eng |
| title | Case Report: Complete tomographic resolution of focal choroidal excavation complicated with choroidal neovascularization after anti-VEGF treatment [version 1; peer review: 2 approved] |
| title_full | Case Report: Complete tomographic resolution of focal choroidal excavation complicated with choroidal neovascularization after anti-VEGF treatment [version 1; peer review: 2 approved] |
| title_fullStr | Case Report: Complete tomographic resolution of focal choroidal excavation complicated with choroidal neovascularization after anti-VEGF treatment [version 1; peer review: 2 approved] |
| title_full_unstemmed | Case Report: Complete tomographic resolution of focal choroidal excavation complicated with choroidal neovascularization after anti-VEGF treatment [version 1; peer review: 2 approved] |
| title_short | Case Report: Complete tomographic resolution of focal choroidal excavation complicated with choroidal neovascularization after anti-VEGF treatment [version 1; peer review: 2 approved] |
| title_sort | case report complete tomographic resolution of focal choroidal excavation complicated with choroidal neovascularization after anti vegf treatment version 1 peer review 2 approved |
| topic | focal choroidal excavation optical coherence tomography choroidal neovascularization eng |
| url | https://f1000research.com/articles/12-1270/v1 |
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