Diagnostic Accuracy of 3.0‐T Magnetic Resonance T1 and T2 Mapping and T2‐Weighted Dark‐Blood Imaging for the Infarct‐Related Coronary Artery in Non–ST‐Segment Elevation Myocardial Infarction
BackgroundPatients with recent non–ST‐segment elevation myocardial infarction commonly have heterogeneous characteristics that may be challenging to assess clinically. Methods and ResultsWe prospectively studied the diagnostic accuracy of 2 novel (T1, T2 mapping) and 1 established (T2‐weighted short...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-04-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.116.004759 |
| _version_ | 1828736816915677184 |
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| author | Jamie Layland Samuli Rauhalammi Matthew M. Y. Lee Nadeem Ahmed Jaclyn Carberry Vannesa Teng Yue May Stuart Watkins Christie McComb Kenneth Mangion John D. McClure David Carrick Anna O'Donnell Arvind Sood Margaret McEntegart Keith G. Oldroyd Aleksandra Radjenovic Colin Berry |
| author_facet | Jamie Layland Samuli Rauhalammi Matthew M. Y. Lee Nadeem Ahmed Jaclyn Carberry Vannesa Teng Yue May Stuart Watkins Christie McComb Kenneth Mangion John D. McClure David Carrick Anna O'Donnell Arvind Sood Margaret McEntegart Keith G. Oldroyd Aleksandra Radjenovic Colin Berry |
| author_sort | Jamie Layland |
| collection | DOAJ |
| description | BackgroundPatients with recent non–ST‐segment elevation myocardial infarction commonly have heterogeneous characteristics that may be challenging to assess clinically. Methods and ResultsWe prospectively studied the diagnostic accuracy of 2 novel (T1, T2 mapping) and 1 established (T2‐weighted short tau inversion recovery [T2W‐STIR]) magnetic resonance imaging methods for imaging the ischemic area at risk and myocardial salvage in 73 patients with non–ST‐segment elevation myocardial infarction (mean age 57±10 years, 78% male) at 3.0‐T magnetic resonance imaging within 6.5±3.5 days of invasive management. The infarct‐related territory was identified independently using a combination of angiographic, ECG, and clinical findings. The presence and extent of infarction was assessed with late gadolinium enhancement imaging (gadobutrol, 0.1 mmol/kg). The extent of acutely injured myocardium was independently assessed with native T1, T2, and T2W‐STIR methods. The mean infarct size was 5.9±8.0% of left ventricular mass. The infarct zone T1 and T2 times were 1323±68 and 57±5 ms, respectively. The diagnostic accuracies of T1 and T2 mapping for identification of the infarct‐related artery were similar (P=0.125), and both were superior to T2W‐STIR (P<0.001). The extent of myocardial injury (percentage of left ventricular volume) estimated with T1 (15.8±10.6%) and T2 maps (16.0±11.8%) was similar (P=0.838) and moderately well correlated (r=0.82, P<0.001). Mean extent of acute injury estimated with T2W‐STIR (7.8±11.6%) was lower than that estimated with T1 (P<0.001) or T2 maps (P<0.001). ConclusionsIn patients with non–ST‐segment elevation myocardial infarction, T1 and T2 magnetic resonance imaging mapping have higher diagnostic performance than T2W‐STIR for identifying the infarct‐related artery. Compared with conventional STIR, T1 and T2 maps have superior value to inform diagnosis and revascularization planning in non–ST‐segment elevation myocardial infarction. Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02073422. |
| first_indexed | 2024-04-12T23:33:18Z |
| format | Article |
| id | doaj.art-ff64ecd47467428698fb1db72612a5ac |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-12T23:33:18Z |
| publishDate | 2017-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-ff64ecd47467428698fb1db72612a5ac2022-12-22T03:12:14ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802017-04-016410.1161/JAHA.116.004759Diagnostic Accuracy of 3.0‐T Magnetic Resonance T1 and T2 Mapping and T2‐Weighted Dark‐Blood Imaging for the Infarct‐Related Coronary Artery in Non–ST‐Segment Elevation Myocardial InfarctionJamie Layland0Samuli Rauhalammi1Matthew M. Y. Lee2Nadeem Ahmed3Jaclyn Carberry4Vannesa Teng Yue May5Stuart Watkins6Christie McComb7Kenneth Mangion8John D. McClure9David Carrick10Anna O'Donnell11Arvind Sood12Margaret McEntegart13Keith G. Oldroyd14Aleksandra Radjenovic15Colin Berry16West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United KingdomBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United KingdomWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United KingdomWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United KingdomBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United KingdomBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United KingdomWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United KingdomBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United KingdomWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United KingdomBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United KingdomWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United KingdomWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United KingdomHairmyres Hospital, East Kilbride, United KingdomWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United KingdomWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United KingdomBHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, United KingdomWest of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Glasgow, United KingdomBackgroundPatients with recent non–ST‐segment elevation myocardial infarction commonly have heterogeneous characteristics that may be challenging to assess clinically. Methods and ResultsWe prospectively studied the diagnostic accuracy of 2 novel (T1, T2 mapping) and 1 established (T2‐weighted short tau inversion recovery [T2W‐STIR]) magnetic resonance imaging methods for imaging the ischemic area at risk and myocardial salvage in 73 patients with non–ST‐segment elevation myocardial infarction (mean age 57±10 years, 78% male) at 3.0‐T magnetic resonance imaging within 6.5±3.5 days of invasive management. The infarct‐related territory was identified independently using a combination of angiographic, ECG, and clinical findings. The presence and extent of infarction was assessed with late gadolinium enhancement imaging (gadobutrol, 0.1 mmol/kg). The extent of acutely injured myocardium was independently assessed with native T1, T2, and T2W‐STIR methods. The mean infarct size was 5.9±8.0% of left ventricular mass. The infarct zone T1 and T2 times were 1323±68 and 57±5 ms, respectively. The diagnostic accuracies of T1 and T2 mapping for identification of the infarct‐related artery were similar (P=0.125), and both were superior to T2W‐STIR (P<0.001). The extent of myocardial injury (percentage of left ventricular volume) estimated with T1 (15.8±10.6%) and T2 maps (16.0±11.8%) was similar (P=0.838) and moderately well correlated (r=0.82, P<0.001). Mean extent of acute injury estimated with T2W‐STIR (7.8±11.6%) was lower than that estimated with T1 (P<0.001) or T2 maps (P<0.001). ConclusionsIn patients with non–ST‐segment elevation myocardial infarction, T1 and T2 magnetic resonance imaging mapping have higher diagnostic performance than T2W‐STIR for identifying the infarct‐related artery. Compared with conventional STIR, T1 and T2 maps have superior value to inform diagnosis and revascularization planning in non–ST‐segment elevation myocardial infarction. Clinical Trial RegistrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT02073422.https://www.ahajournals.org/doi/10.1161/JAHA.116.004759acute coronary syndromearea at riskedemamappingnoninvasive imagingnon–ST‐segment elevation acute coronary syndrome |
| spellingShingle | Jamie Layland Samuli Rauhalammi Matthew M. Y. Lee Nadeem Ahmed Jaclyn Carberry Vannesa Teng Yue May Stuart Watkins Christie McComb Kenneth Mangion John D. McClure David Carrick Anna O'Donnell Arvind Sood Margaret McEntegart Keith G. Oldroyd Aleksandra Radjenovic Colin Berry Diagnostic Accuracy of 3.0‐T Magnetic Resonance T1 and T2 Mapping and T2‐Weighted Dark‐Blood Imaging for the Infarct‐Related Coronary Artery in Non–ST‐Segment Elevation Myocardial Infarction Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease acute coronary syndrome area at risk edema mapping noninvasive imaging non–ST‐segment elevation acute coronary syndrome |
| title | Diagnostic Accuracy of 3.0‐T Magnetic Resonance T1 and T2 Mapping and T2‐Weighted Dark‐Blood Imaging for the Infarct‐Related Coronary Artery in Non–ST‐Segment Elevation Myocardial Infarction |
| title_full | Diagnostic Accuracy of 3.0‐T Magnetic Resonance T1 and T2 Mapping and T2‐Weighted Dark‐Blood Imaging for the Infarct‐Related Coronary Artery in Non–ST‐Segment Elevation Myocardial Infarction |
| title_fullStr | Diagnostic Accuracy of 3.0‐T Magnetic Resonance T1 and T2 Mapping and T2‐Weighted Dark‐Blood Imaging for the Infarct‐Related Coronary Artery in Non–ST‐Segment Elevation Myocardial Infarction |
| title_full_unstemmed | Diagnostic Accuracy of 3.0‐T Magnetic Resonance T1 and T2 Mapping and T2‐Weighted Dark‐Blood Imaging for the Infarct‐Related Coronary Artery in Non–ST‐Segment Elevation Myocardial Infarction |
| title_short | Diagnostic Accuracy of 3.0‐T Magnetic Resonance T1 and T2 Mapping and T2‐Weighted Dark‐Blood Imaging for the Infarct‐Related Coronary Artery in Non–ST‐Segment Elevation Myocardial Infarction |
| title_sort | diagnostic accuracy of 3 0 t magnetic resonance t1 and t2 mapping and t2 weighted dark blood imaging for the infarct related coronary artery in non st segment elevation myocardial infarction |
| topic | acute coronary syndrome area at risk edema mapping noninvasive imaging non–ST‐segment elevation acute coronary syndrome |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.116.004759 |
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