Association between the number of pregnancies and cardiac target organ damages: a cross-sectional analysis of data from the Korean women’s chest pain registry (KoROSE)
Abstract Background Pregnancy increases long-term cardiovascular risk after childbirth, but the mechanisms are unclear. This study was performed to investigate the association between the number of pregnancies and several cardiac target organ damage (TOD) in middle-aged and elderly women. Methods Us...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-07-01
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| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12905-023-02514-w |
| _version_ | 1797773994316791808 |
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| author | Hack-Lyoung Kim Hyun-Jin Kim Mina Kim Sang Min Park Hyun Ju Yoon Young Sup Byun Seong-Mi Park Mi-Seung Shin Kyung-Soon Hong Myung-A Kim |
| author_facet | Hack-Lyoung Kim Hyun-Jin Kim Mina Kim Sang Min Park Hyun Ju Yoon Young Sup Byun Seong-Mi Park Mi-Seung Shin Kyung-Soon Hong Myung-A Kim |
| author_sort | Hack-Lyoung Kim |
| collection | DOAJ |
| description | Abstract Background Pregnancy increases long-term cardiovascular risk after childbirth, but the mechanisms are unclear. This study was performed to investigate the association between the number of pregnancies and several cardiac target organ damage (TOD) in middle-aged and elderly women. Methods Using the database of the nation-wide registry, a total of 1,137 women (mean age 63.0 ± 10.9 years) with stable chest pain undergoing invasive coronary angiography (CAG) were analyzed. Information on the number of pregnancies was obtained through a questionnaire. Obstructive coronary artery disease (CAD), left ventricular (LV) mass index (LVMI) and LV septal annular (e′) velocity were assessed as indicators of cardiac TOD. Results Women with higher number of pregnancies (≥ 3) were older (66.3 ± 9.6 vs. 57.4 ± 10.7 years; P < 0.001), had more cardiovascular risk factors, and took more cardiovascular medications than those with lower number of pregnancies (< 3). In multivariable analyses, higher number of pregnancies (≥ 3) was associated with obstructive CAD (odds ratio [OR], 1.62; 95% confidence interval [CI], 1.21–2.17; P = 0.001), a higher LVMI (> 95 g/m2) (OR, 1.46; 95% CI, 1.08–1.98; P = 0.013) and a lower septal e′ velocity (< 7 cm/s) (OR, 1.55; 95% CI, 1.12–2.14; P = 0.007) even after controlling for potential confounders. As the number of pregnancies increased, the prevalence of CAD and LVMI increased, and the septal e’ velocity gradually decreased (P < 0.001 for each). Conclusions In women with chest pain undergoing invasive CAG, higher number of pregnancies was associated with multiple cardiac TOD. Parity information should be checked when assessing a woman’s cardiovascular risk. |
| first_indexed | 2024-03-12T22:14:01Z |
| format | Article |
| id | doaj.art-ff682770c5e44fd8b609501fbf01cec2 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-03-12T22:14:01Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-ff682770c5e44fd8b609501fbf01cec22023-07-23T11:25:41ZengBMCBMC Women's Health1472-68742023-07-012311810.1186/s12905-023-02514-wAssociation between the number of pregnancies and cardiac target organ damages: a cross-sectional analysis of data from the Korean women’s chest pain registry (KoROSE)Hack-Lyoung Kim0Hyun-Jin Kim1Mina Kim2Sang Min Park3Hyun Ju Yoon4Young Sup Byun5Seong-Mi Park6Mi-Seung Shin7Kyung-Soon Hong8Myung-A Kim9Division of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Boramae Medical CenterDivision of Cardiology, Department of Internal Medicine, Hanyang University Guri HospitalDivision of Cardiology, Department of Internal Medicine, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Eulji University School of Medicine, Nowon Eulji Medical CenterDivision of Cardiology, Department of Internal Medicine, Chonnam National University HospitalDivision of Cardiology, Department of Internal Medicine, Inje University Sanggye Paik HospitalDivision of Cardiology, Department of Internal Medicine, Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Gil Medical CenterDivision of Cardiology, Department of Internal Medicine, Hallym University Medical CenterDivision of Cardiology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Boramae Medical CenterAbstract Background Pregnancy increases long-term cardiovascular risk after childbirth, but the mechanisms are unclear. This study was performed to investigate the association between the number of pregnancies and several cardiac target organ damage (TOD) in middle-aged and elderly women. Methods Using the database of the nation-wide registry, a total of 1,137 women (mean age 63.0 ± 10.9 years) with stable chest pain undergoing invasive coronary angiography (CAG) were analyzed. Information on the number of pregnancies was obtained through a questionnaire. Obstructive coronary artery disease (CAD), left ventricular (LV) mass index (LVMI) and LV septal annular (e′) velocity were assessed as indicators of cardiac TOD. Results Women with higher number of pregnancies (≥ 3) were older (66.3 ± 9.6 vs. 57.4 ± 10.7 years; P < 0.001), had more cardiovascular risk factors, and took more cardiovascular medications than those with lower number of pregnancies (< 3). In multivariable analyses, higher number of pregnancies (≥ 3) was associated with obstructive CAD (odds ratio [OR], 1.62; 95% confidence interval [CI], 1.21–2.17; P = 0.001), a higher LVMI (> 95 g/m2) (OR, 1.46; 95% CI, 1.08–1.98; P = 0.013) and a lower septal e′ velocity (< 7 cm/s) (OR, 1.55; 95% CI, 1.12–2.14; P = 0.007) even after controlling for potential confounders. As the number of pregnancies increased, the prevalence of CAD and LVMI increased, and the septal e’ velocity gradually decreased (P < 0.001 for each). Conclusions In women with chest pain undergoing invasive CAG, higher number of pregnancies was associated with multiple cardiac TOD. Parity information should be checked when assessing a woman’s cardiovascular risk.https://doi.org/10.1186/s12905-023-02514-wCoronary angiographyDiastolic functionLeft ventricular massParityPregnancyTarget organ damage |
| spellingShingle | Hack-Lyoung Kim Hyun-Jin Kim Mina Kim Sang Min Park Hyun Ju Yoon Young Sup Byun Seong-Mi Park Mi-Seung Shin Kyung-Soon Hong Myung-A Kim Association between the number of pregnancies and cardiac target organ damages: a cross-sectional analysis of data from the Korean women’s chest pain registry (KoROSE) BMC Women's Health Coronary angiography Diastolic function Left ventricular mass Parity Pregnancy Target organ damage |
| title | Association between the number of pregnancies and cardiac target organ damages: a cross-sectional analysis of data from the Korean women’s chest pain registry (KoROSE) |
| title_full | Association between the number of pregnancies and cardiac target organ damages: a cross-sectional analysis of data from the Korean women’s chest pain registry (KoROSE) |
| title_fullStr | Association between the number of pregnancies and cardiac target organ damages: a cross-sectional analysis of data from the Korean women’s chest pain registry (KoROSE) |
| title_full_unstemmed | Association between the number of pregnancies and cardiac target organ damages: a cross-sectional analysis of data from the Korean women’s chest pain registry (KoROSE) |
| title_short | Association between the number of pregnancies and cardiac target organ damages: a cross-sectional analysis of data from the Korean women’s chest pain registry (KoROSE) |
| title_sort | association between the number of pregnancies and cardiac target organ damages a cross sectional analysis of data from the korean women s chest pain registry korose |
| topic | Coronary angiography Diastolic function Left ventricular mass Parity Pregnancy Target organ damage |
| url | https://doi.org/10.1186/s12905-023-02514-w |
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