scDemultiplex: An iterative beta-binomial model-based method for accurate demultiplexing with hashtag oligos

scDemultiplex: An iterative beta-binomial model-based method for accurate demultiplexing with hashtag oligos

Single-cell sequencing have been widely used to characterize cellular heterogeneity. Sample multiplexing where multiple samples are pooled together for single-cell experiments, attracts wide attention due to its benefits of increasing capacity, reducing costs, and minimizing batch effects. To analyz...

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Bibliographic Details
Main Authors: Li-Ching Huang, Lindsey K. Stolze, Hua-Chang Chen, Alexander Gelbard, Yu Shyr, Qi Liu, Quanhu Sheng
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Single-cell sequencing
Hashtag oligo (HTO)
Demultiplexing
Beta-binomial
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702300288X

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