Pharmacokinetics/pharmacodynamics of L‐ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes

Pharmacokinetics/pharmacodynamics of L‐ornithine phenylacetate in overt hepatic encephalopathy and the effect of plasma ammonia concentration reduction on clinical outcomes

Abstract Hepatic encephalopathy (HE) is a serious neurocognitive complication of liver dysfunction, often associated with elevated plasma ammonia. Ornithine phenylacetate (OP), a potent ammonia scavenger, is being evaluated for the treatment of acute/overt HE. The pharmacokinetics and pharmacodynami...

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Bibliographic Details
Main Authors: Rifaat Safadi, Robert S. Rahimi, Dominique Thabut, Jasmohan S. Bajaj, Kalyan Ram Bhamidimarri, Nikolaos Pyrsopoulos, Amy Potthoff, Stan Bukofzer, Laurene Wang, Khurram Jamil, Krishna R. Devarakonda
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13257

Internet

https://doi.org/10.1111/cts.13257

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