Association between serum midkine levels and tumor size in Indonesian hepatocellular carcinoma patients: a cross-sectional study

Background: The incidence of liver cancer is increased worldwide with 75%–85% diagnosed as hepatocellular carcinoma (HCC). Current practice has low sensitivity limitations to diagnose the early stages of HCC, thus urging the need for a biomarker with higher sensitivity to detect HCC, specifically in...

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Bibliographic Details
Main Authors: Darmadi Darmadi, Ruslie Riska Habriel, Pakpahan Cennikon
Format: Article
Language:English
Published: Sciendo 2022-12-01
Series:Romanian Journal of Internal Medicine
Subjects:
Online Access:https://doi.org/10.2478/rjim-2022-0014
Description
Summary:Background: The incidence of liver cancer is increased worldwide with 75%–85% diagnosed as hepatocellular carcinoma (HCC). Current practice has low sensitivity limitations to diagnose the early stages of HCC, thus urging the need for a biomarker with higher sensitivity to detect HCC, specifically in the early stage. This study aimed to determine the association between midkine levels and progressiveness of hepatocellular carcinoma (HCC), according to tumor size, Barcelona Clinic Liver Cancer (BCLC), and presence of portal venous thrombosis.
ISSN:2501-062X