Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia
Abstract Existing studies on cognitive impairments in chronic pain do not investigate peripheral neuropathic pain (PNP) or compare pain conditions in a satisfactory manner. Here we aimed to compare executive dysfunctions in PNP patients with fibromyalgia (FM) and healthy controls (HC). Patients who...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-80740-0 |
| _version_ | 1818997820890284032 |
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| author | Henrik Børsting Jacobsen Tore C. Stiles Audun Stubhaug Nils Inge Landrø Per Hansson |
| author_facet | Henrik Børsting Jacobsen Tore C. Stiles Audun Stubhaug Nils Inge Landrø Per Hansson |
| author_sort | Henrik Børsting Jacobsen |
| collection | DOAJ |
| description | Abstract Existing studies on cognitive impairments in chronic pain do not investigate peripheral neuropathic pain (PNP) or compare pain conditions in a satisfactory manner. Here we aimed to compare executive dysfunctions in PNP patients with fibromyalgia (FM) and healthy controls (HC). Patients who self-reported cognitive impairments were assessed according to criteria for PNP or FM. Seventy-three patients met criteria and completed testing on executive functioning and IQ measures. We also included twenty matched healthy controls. Regression models controlling for age, sex and IQ, tested associations between group category (PNP, FM or HC) and outcomes. If a substantial association was detected, we followed up with head-to-head comparisons between PNP and FM. Multivariate regression models then tested associations between executive functioning and pain type, controlling for significant confounders. Results from head-to-head comparison between pain conditions showed significant differences on years lived with pain (FM > PNP), the use of anticonvulsants (PNP > FM) and use of analgesics (PNP > FM). When controlled for all significant differences, PNP patients had significantly lower scores on an attention-demanding cued-recall task compared to FM. Poor performance on attention-demanding cued-recall task was associated with PNP, which translate into problems with retaining fast-pace or advanced information. |
| first_indexed | 2024-12-20T21:51:43Z |
| format | Article |
| id | doaj.art-ff6c5848a3aa4f92b83907cce3b21acb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T21:51:43Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ff6c5848a3aa4f92b83907cce3b21acb2022-12-21T19:25:33ZengNature PortfolioScientific Reports2045-23222021-01-0111111010.1038/s41598-020-80740-0Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgiaHenrik Børsting Jacobsen0Tore C. Stiles1Audun Stubhaug2Nils Inge Landrø3Per Hansson4The Mind-Body Lab, Department of Psychology, University of OsloDepartment of Psychology, Norwegian University of Science and TechnologyNorwegian National Advisory Unit On Neuropathic Pain, Oslo University HospitalClinical Neuroscience Research Group, Department of Psychology, University of OsloNorwegian National Advisory Unit On Neuropathic Pain, Oslo University HospitalAbstract Existing studies on cognitive impairments in chronic pain do not investigate peripheral neuropathic pain (PNP) or compare pain conditions in a satisfactory manner. Here we aimed to compare executive dysfunctions in PNP patients with fibromyalgia (FM) and healthy controls (HC). Patients who self-reported cognitive impairments were assessed according to criteria for PNP or FM. Seventy-three patients met criteria and completed testing on executive functioning and IQ measures. We also included twenty matched healthy controls. Regression models controlling for age, sex and IQ, tested associations between group category (PNP, FM or HC) and outcomes. If a substantial association was detected, we followed up with head-to-head comparisons between PNP and FM. Multivariate regression models then tested associations between executive functioning and pain type, controlling for significant confounders. Results from head-to-head comparison between pain conditions showed significant differences on years lived with pain (FM > PNP), the use of anticonvulsants (PNP > FM) and use of analgesics (PNP > FM). When controlled for all significant differences, PNP patients had significantly lower scores on an attention-demanding cued-recall task compared to FM. Poor performance on attention-demanding cued-recall task was associated with PNP, which translate into problems with retaining fast-pace or advanced information.https://doi.org/10.1038/s41598-020-80740-0 |
| spellingShingle | Henrik Børsting Jacobsen Tore C. Stiles Audun Stubhaug Nils Inge Landrø Per Hansson Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia Scientific Reports |
| title | Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia |
| title_full | Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia |
| title_fullStr | Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia |
| title_full_unstemmed | Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia |
| title_short | Comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia |
| title_sort | comparing objective cognitive impairments in patients with peripheral neuropathic pain or fibromyalgia |
| url | https://doi.org/10.1038/s41598-020-80740-0 |
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